Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 132 for “"Cell signalling"”.
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Cell Signalling and MicroRNAs: Regulation and Evolution
Cell signalling is among the most studied topics in modern biology, it allows cells to communicate with each other and their environment and thus, orchestrates the entire functioning of organisms. Despite being studied for more than a century, the field of cell signalling has recently evolved as …
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Development of novel imaging technology to study cell signalling
Currently it is difficult to study signalling on living cells at the single molecule level. One problem is that it is not possible to trigger signalling in a controlled manner and there is no effective method that can both introduce a precise amount of molecules onto or into a single cell at a …
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B cell signalling in mechanisms of central and peripheral tolerance
… system to prevent autoimmunity. Hence during B cell development, a number of central and peripheral developmental checkpoints ensure the deletion of self-reactive B cells and selection of tolerant B cells. For example, antigen-driven ligation of the B cell receptor (BCR) on immature B cells …
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Effects of Polyphenols on Vasomodulatory Factors and Associated Cell Signalling
… used to treat human umbilical vein endothelial cells (HUVECs), to assess effects on the abundance or activity of signalling molecules related to increased vasodilation, a hallmark of improved endothelial function. Specifically, Akt and eNOS phosphorylation, levels of total eNOS protein and cGMP, …
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Role of DARPP-32 in Breast Cancer Cell Signalling and Migration
… known to inhibit migration of breast epithelial cells in culture and expression of Wnt-5a potentiates activation of the receptor tyrosine kinase DDR1, a collagen receptor implicated in cell adhesion and migration. This thesis describes the identification of DARPP-32 as a novel interactionpartner …
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Multiscale Modelling and Analysis of Plant Cell Signalling Processes and Biomechanics
… are regulated by complex networks of interacting signalling molecules. Signalling pathways activate in response to external or internal cues, leading to a series of signalling processes which end with changes in gene expression. By modifying protein level in this way, specific signalling molecules …
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Investigating the Role of Oncogenic KRAS G12 Mutations in Cell Signalling
… that drive progressive transformation of normal cells into highly proliferative malignant cells. Deregulation of cellular signalling is one of the key traits in cancer, allowing cells to breach anticancer defence mechanisms. The most frequently mutated oncogene in cancer is KRAS, encoding a small …
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Investigation of T cell signalling events regulating immunity and tolerance in vivo
… to self antigens is to prevent self-reactive T cells from exiting the thymus following their development therein (central tolerance). However, some self-reactive T cells escape thymic deletion and as such, central tolerance is incomplete. Indeed, peripheral tolerance is required for an …
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Investigation of plant derived compounds mediating cell signalling effectson FOXO1a and AMPK
… extracts with:<br/>Insulin-like properties in cell culture experiments in that they induce phosphorylation and therefore inactivation of the transcription factor FOXO1a, which is a major downstream effector insulin and<br/>Properties similar to the T2D drugs metformin and pioglitazone, which …
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Evaluating interactive network visualisations: a case study using the cell Signalling Visualisation Toolkit
… causes of death worldwide and arises from cells that do not function properly. Cell functioning is governed in part by signalling pathways within the cell that translate environmental signals detected at the cell membrane into cell behaviour. The dynamic nature and topological complexity of …
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Development of an Optogenetic Toolkit for the Interrogation of T cell Signalling Dynamics
T cells are a cornerstone of the mammalian adaptive immune system. A range of T-cell subsets exist that can orchestrate the overall immune response to pathogens or cancers, either by directly killing infected cells or licensing other cells to do so. Dysregulation of this important process can …
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Nutritional Manipulation of Exercise Induced Skeletal Muscle Cell Signalling: Implications for Acute Training Adaptations
… regulated through free fatty acid (FFA)-mediated signalling, the aim of study 1 (chapter 4) was to test the hypothesis that leucine-enriched protein feeding before and during exercise does not impair FFA availability or whole body lipid oxidation during exercise. Here I utulised a novel leucine …
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Obesity and neuroinflammation : the impact of adipocyte-derived extracellular vesicles on microglial cell signalling
… neuroinflammation is poorly understood. Extracellular vesicles (EVs) are nanoparticles released from most cell types and aid in cell-cell communication. Adipocyte-derived extracellular vesicles (AT-EVs) are known to be involved in interorgan crosstalk during obesity and therefore may be a key …
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To signal or not to signal: Molecular information processing through the B-cell signalling network
Contains fulltext : 321287.pdf (Publisher’s version ) (Open Access)
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The effects of statins on hypoxia-induced proliferation and cell signalling pathways in pulmonary artery fibroblasts
… of PAFs. Morevoer, it is likely that cell-cell interactions between hypoxia-stimulated PAFs and other vascular cells – particularly smooth muscle cells - initiates and progresses the changes that occur in pulmonary vascular remodelling in the other vessel compartments. Although hypoxic …
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Exercise-induced cell signalling responses of human skeletal responses of human skeletal muscle: the effects of reduced carbohydrate availability
… techniques now permit the examination of the cell signalling responses to acute exercise therefore increasing our understanding of how manipulation of the training protocol and nutrient availability may enhance the training stimulus to a given bout of exercise. The primary aim of this thesis …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… disease characterised by increased smooth muscle cell (SMC) inflammation and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… disease characterised by increased smooth muscle cell (SMC) inflammation and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological …
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A NOVEL PIPELINE FOR DRUG DISCOVERY IN NEUROPSYCHIATRIC DISORDERS USING HIGH-CONTENT SINGLE-CELL SCREENING OF SIGNALLING NETWORK RESPONSES EX VIVO
… measurement of kinetic ligand responses across cell signalling networks at the single-cell level in distinct PBMC subtypes ex vivo. Using automated sample preparation, fluorescent cellular barcoding and flow cytometry the platform is capable of detecting 21, 840 parallel cell signalling …
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Engineering LuxR-type quorum sensing proteins for new functions
… actuating downstream gene expression based on cell-cell signalling. Cell-cell signalling allows for complex and multi-cellular behavior otherwise impossible with unicellular logic. However, building complex cell-cell signalling genetic circuits is currently challenged by a lack of tools for the …
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