Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Cell signaling processes"”.
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Development of Chemical Tools to Discover and Characterize Sialic Acid Mediated Interactions
… other biomolecules. Proteins and lipids on the cell surface are frequently found to be glycosylated. This glycosylation can have a number of functions, one of which is to mediate specific binding interactions between the glycans of glycoconjugates and glycan binding proteins. Such …
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Engineering the Structure of the Human Acidic Fibroblast Growth Factor to Enhance its Stability and Cell Proliferation Activity
… (hFGF1) is a protein well known for its role in cell growth and differentiation. To elicit these cell-signaling processes, hFGF1 non-selectively binds to any one of the seven cell surface hFGF receptor isoforms. Due to its significant involvement in tissue repair activity, hFGF1 is a prime …
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Design principles of mammalian signaling networks : emergent properties at modular and global scales
… chemistry to investigate several aspects of cellular signal transduction at both the modular and global levels. Design principles of biological networks and cell signaling processes pertinent to disease progression emerge from these studies. It is my hope that knowledge of these principles …
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Identifying the Relevance of C-Reactive Protein Conformers and the Advancement of a Membrane Curvature Binding Assay
<p>Lipid membranes play a vital role in cell signaling processes. Membrane shape and lipid content affect interactions between cellular membranes and proteins. This research focuses on characterizing those interactions and their impact by using various biochemical and biophysical assays. These …
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Biochemical and Biophysical Studies of Novel Features of Ras-related Protein Interactions
… of various biochemical reactions in the cell. They are regulated by protein-protein interactions targeted to the highly flexible switch regions. Mutations in G-proteins or their effectors may cause alterations in structure and/or function that can lead to overactivity.</p> <p>The …
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Omics approach towards understanding the function of bioactive lipids in osteosarcoma
… stabilize the membrane proteome of osteosarcoma cells in nanodiscs (chapter 3). Nanodiscs are lipid bilayers surrounded by membrane scaffold protein and provide the amphipathic environment for membrane proteins. In this study we showed that lipid composition affects the protein composition …
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Structural studies of membrane-associated complexes by solid-state NMR
… composition of which directly regulates all extracellular interactions and trafficking of materials. The inherent asymmetry of the plasma membrane composition is directly involved in cell signaling processes and normal biological functions of the cell. This thesis utilizes solid-state nuclear …