Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Cell replacement therapy"”.
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Hematopoietic stem and progenitor cells and potentials for application in fetal cell replacement therapy
Fetal cell replacement therapy or in utero hematopoietic cell transplantation (IUHCT) is proposed as a non-myeloablative alternative to bone marrow transplantation (BMT) for a number of inborn immunologic, hematologic and metabolic disorders. IUHCT represents the method through which variable …
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Neural Stem Cells - interaction with the brain and prospects for cell replacement therapy for Stroke
… as astrocytes and oligodendrocytes. Neural stem cells (NSCs) could potentially be used to develop novel therapies to restore loss of function after stroke. We generated a NSC line derived as monolayer cultures from the human fetal striatum, termed NS, and described the in vitro and in vivo …
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CELL REPLACEMENT THERAPY FOR PARKINSON’S DISEASE: The importance of neuronal subtype, cell source and connectivity for functional recovery
… therapeutic options. One such idea is cell replacement therapy (CRT). CRT aims to replace neurons that have degenerated in PD, with donor cells that have the potential to functionally re-integrate into the host circuitry. This involves transplantation of developing midbrain cells from …
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Applications for human neural stem cell-derived motor neurons in amyotrophic lateral sclerosis: Cell replacement therapy and disease modeling
… explore the potential of human fetal neural stem cells (hNSCs) to replace lost motor neurons. The therapeutic efficacy of stem cell transplantation would depend greatly on the survival of grafted stem cell-derived motor neurons in the microenvironment of the spinal cord in ALS. Previously, we …
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Generation of cells for cell-replacement therapy: Specification of neural precursors in vivo and in neural stem cell cultures
Cell replacement therapy of neurodegenerative disorders aims to substitute the degenerating cells with new functional neurons. Clinical trails with patients suffering from Parkinson’s or Huntington’s disease have generated proof-of-principle results that neural precursors taken from the developing …
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Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons
… for PD are highly warranted. The concept of cell replacement therapy in PD is based on the idea that the diminished dopamine levels in the striatum would be restored by the functional DNs, obtained from donated, electively aborted fetuses, and subsequently injected into the patients’ …
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Human neural stem cells: region-specific properties and prospects for cell therapy
Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. The human fetal brain is one potential source of neural …
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Identification of dopamine neuron progenitors in the embryonic midbrain and stem cell cultures - Studies on the role of neuronal subtype and differentiation state for cell replacemen in a rodent model of Parkinson's disease
… therapies. A promising alternative approach is cell replacement therapy, which aims to replacethe lost dopamine-producing neurons by transplanting cells with equivalent properties. Clinical transplantations using cells obtained from foetal VM tissue have provided the proof-of-principle that cell …
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Stem cell-based regenerative pharmacology for the treatment of diabetes mellitus
Stem cell-based regenerative pharmacology is aimed at establishing stem and progenitor cells as effective treatment for preventing disease and facilitating organ replacement or repair. Diabetes mellitus (DM) is a group of chronic metabolic disorders characterized by high blood glucose levels. Type …
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Encapsulation as a 3D model for human embryonic stem cell propagation and differentiation
… disease caused by the destruction of the beta cells of the pancreas. Current treatments for are whole pancreas or islet transplantation, which is limited by scarcity of cadaveric pancreata. Therefore, developing a cell replacement therapy with renewable sources of surrogate beta cells is …
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Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy
… the feasibility and potential for novel gene and cell therapy approaches, which hold better promise for neurological disorders, while particularly targeting epilepsy. Epilepsy is a multifactorial neurological disorder affecting 1% of the population. Available pharmacological therapies are merely …
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A microfabricated 3-D stem cell delivery scaffold for retinal regenerative therapy
… result in the degeneration of the photoreceptor cells and can ultimately lead to blindness in patients. There is currently no cure for AMD or RP, and only a few methods exist for slowing the progression of these diseases. Although there has been much recent headway in cell replacement therapy to …
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Targeted Epigenetic Editing to Increase Adult Pancreatic Β-Cell Proliferation
β-cell replacement therapy is potentially a curative approach in treating diabetes, as demonstrated by the success of pancreatic islet transplantation in type 1 diabetes. However, there are an insufficient number of organ donors to meet the demand of this disease, which is increasing in prevalence. …
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Generation of induced progenitor-like (iPL) cells using interrupted reprogramming
… medicine is constrained by suboptimal cell sources with either limited or uncontrolled proliferation and/or incompletely restricted differentiation. We developed a novel "interrupted reprogramming" strategy without traversing the pluripotent state, to generate "induced Progenitor-Like …
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Engineered Tracking and Delivery of Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) are tissue culture plastic adherent cells that are able to differentiate into multiple cell types, modulate the immune system, and aid in wound repair. These versatile cells are thus being investigated to treat a wide variety of different diseases such as graft vs. …
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Investigating factors governing cell fate decisions in respiratory epithelium
… embryonic development require tightly regulated cell fate decisions. This regulation takes the form of complex transcription factor and signalling cascades, much of which are unknown, particularly in human lung development. Multiciliogenesis describes the process of specification/differentiation …
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Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2
… in PD patients. Clinical trials have shown that cell replacement therapy, where dopaminergic neuroblasts derived from fetal ventral mesencephalon (VM) are transplanted to the striatum, may be an alternative to pharmacological treatment of PD patients. The limited access and ethical concerns with …
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Investigating three-dimensional (3D) gelatin methacryloyl (GelMA) hydrogel as a potential scaffold for cell transplantation in Huntington's disease
… CAG repeats that form mutant huntingtin protein. Cell replacement therapy (CRT) offers a potential pathway to treat HD by replacing the striatal neurons lost during the disease progression with healthy ones. The emergence of cell reprogramming technology offers a powerful tool to generate an …
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Molecular Mechanisms Involved In Krabbe's Disease
La leucodistrofia di Krabbe o a cellule globoidi è un disturbo autosomico recessivo a carico del gene codificante per galactosilcerebrosidase (GALC). GALC è coinvolto nel catabolismo di due lipidi molto prodotti nel processo di formazione della guaina mielinica: galactosilceramide e psicosina. A …
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Microscale Tissue Engineering and Contributors of the Cellular Niche
The behaviour of cells is modulated by their microenvironment or ‘niche’. While cellular therapies offer promising curative solutions for many diseases, the efficacy of transplanted cells is often hampered by a suboptimal microenvironment. One strategy to overcome this limitation is to reconstruct …