Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 465 for “"Cell populations"”.
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Immunogeneic Cell Populations of the Skin
Dendritic cells (DCs), a hematopoietic cell type belonging to the sub-group of cells called antigen presenting cells (APCs), inhabit a central role in innate and adaptive immunity. Although the DC family is very heterogeneous, all members share unique features. Most importantly, DCs can stimulate …
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ZIPRO1: Fine Tuning Proliferation in Discrete Cell Populations
… of expression in several tissues. The main cells expressing Zipro1 are proliferating cells from epidermal lineages. This includes the cerebellar granule cells (GCs), nasal epithelia and dermal papilla. Through gene dosage experiments we have shown that Zipro1 is involved in proliferation …
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Steroidogenic cell populations in follicles of the chicken ovary
A two cell theory for steroidogenesis in preovulatory follicles of the chicken ovary states that the granulosa layer metabolizes cholesterol to progestins and progestins are, then, metabolized to androgens and estrogens by the theca layer. However, the precise site of steroidogenic cells in the …
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Novel intracellular signalling regulators of cartilage progenitor cell populations
… delivery of bone marrow and its constituent cell populations to the site of cartilage damage to form a regenerative clot have proved promising in repairing joint cartilage defects. In order to improve such regenerative technique, further research is required to provide a deeper understanding …
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Alterations in endometrial immune cell populations affect endometrial cell functions
… as the related infertility. Among other immune cells, the T-helper lymphocytes accumulate in the normal endometrium during the mid- to late-secretory phase of the menstrual cycle and are considered essential for endometrial receptivity. The goal of this project was to 1) study the relationship …
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Use of gene expression to characterize heterogeneous liver cell populations
Non-parenchymal cells (NPC's) are integral to recreate the native hepatic microenvironment and necessary to maintain in vivo liver function. A variety of in vitro culture systems have been developed to address different aspects of liver physiology and architecture in order to recreate the …
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Quantitative analysis of apoptotic decisions in single cells and cell populations
Apoptosis is a form of programmed cell death that is essential for the elimination of damaged or unneeded cells in multicellular organisms. Inactivation of apoptotic cell death is a necessary step in the development of cancer, while hypersensitivity to apoptosis is a factor in degenerative …
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Differential expression and phenotypic activities of osterix in equine mesenchymal stem cell populations
… adequately. There is considerable overlap in the cellular and molecular events occurring during embryological bone development and fracture repair. Mesenchymal stem cell (MSC) precursors undergo osteogenesis to give rise to osteoblasts, which are responsible for bone matrix synthesis and …
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Somatic Stem Cell Populations and Studies on the Functional Role and Regulation of ABCG2
… that was identified in breast cancer cells due to its ability to efflux chemotherapeutic drugs. Abcg2 can also efflux Hoechst 33342, resulting in a side population phenotype when stained cells are sorted by FACS. Recent studies have suggested that Abcg2 may be a marker for stem and …
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The Effect of the Conceptus on Endometrial Angiogenesis and Immune Cell Populations During Implantation
… factors produced by the conceptus that target cells of the endometrium during this period of time when the endometrium is undergoing decidualization. This review focuses on some of the approaches that have been used in the past and what has been learned about the effect of the conceptus on the …
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Separation and Further Characterization of Hematopoietic Cell Populations Based on Phenotypic and Biophysical Properties
Hematopoietic stem cells (HSC) are multipotent and possess self-renewal capacity. Thus, they can sustain a life-long hematopoiesis and are also capable of restoring the hematopoietic system when transplanted to a patient. In allogeneic hematopoietic stem cell transplantation (HSCT), a potent …
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Exploring nanoparticles' interactions with blood proteins and visualizing the heterogeneity within hematopoietic cell populations
… of targeted drug delivery by recognizing target cells and selectively delivering the therapeutic drugs to these cells. However, functionalized-NPs often have low targeting efficiency when they are administered in vivo. One of the major causes of this unfavorable outcome is that proteins and other …
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Investigating The Role of The P63 Isoform Δnp63 In Lung Stem Cell Populations and Lung Cancer
<p>Cell of origin studies have determined separate populations of lung progenitor cells that give rise to lung adenocarcinoma and squamous cell carcinoma. ΔNp63 is known to regulate lung development but its role in lung cancer progression remains unclear. We utilized a ΔNp63-specific conditional …
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Examining the roles of resident non-myogenic mesenchymal cell populations in skeletal muscle development and injury
… from both myogenic and their supportive niche cells. The muscular niche is complex. At the cellular level it is composed of a broad number of cell types including: endothelial vessels, nerve and nerve-supporting cells, resident immune populations, and a heterogenous group of non-myogenic …
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MiR-10a Regulation of Drug Response and Cancer Stem Cell Populations in Non-Small Cell Lung Carcinomas
… (PI3Ks) are enzymes involved in diverse cellular functions including cell growth, proliferation, differentiation, motility, survival and apoptosis. Many of these functions relate to class I PI3Ks, heterodimers composed of regulatory and catalytic subunits that convert extracellular cues …
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Phenotypical and functional characterisation of germinative cell populations in human epidermis. In vitro and in vivo studies
Contains fulltext : 146914.pdf (Publisher’s version ) (Open Access)
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Characterization of Immune Cell Populations in White Adipose Tissue of Wild Type and Bovine Growth Hormone Transgenic Mice
… mostly of adipocytes, but contains other cell types, including a variety of immune cells such as macrophages, T cells, Natural Killer T cells (NK), and depot specific differences in cellular composition and endocrine output. Growth hormone (GH) has been shown to impact immune function as …
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Development of a MACS-based strategy for isolating rare cell populations from animal tissue for transcription factor studies
Two major challenges in studying specific cell populations of embryos or adult organs are: a) getting the sample sufficiently pure for the cells of interest; b) getting sufficient quantities of these cells. Current methods used for isolating specific cell populations from tissues are either too …
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The influence of nanotopographical structures on osteoblast adhesion formation and the functional response of mesenchymal stem cell populations
… of these devices in an attempt to regulate cellular adhesion, a process fundamental in the initiation of osteoinduction and osteogenesis. Advances in fabrication techniques have evolved the field of surface modification and, in particular, nanotechnology has allowed the development of …
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