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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Cell monolayers"”.
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Leafhopper-Borne Viruses on Vector-Cell Monolayers
Made available in DSpace on 2014-12-09T18:06:32Z (GMT). No. of bitstreams: 1 7013397.pdf: 2252370 bytes, checksum: d282d7fb563d08138fa13487399e9357 (MD5) Previous issue date: 1969
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Assay of Potato Yellow Dwarf Virus on Leafhopper Cell Monolayers
Made available in DSpace on 2014-12-10T23:32:42Z (GMT). No. of bitstreams: 1 7206958.pdf: 2489105 bytes, checksum: 36947b4a77f3a5e3734406c304820ff3 (MD5) Previous issue date: 1971
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Contribution to the development of Love wave Sensors for cell monolayers mechanical properties assessment
Les monocouches cellulaires sont l’un des principaux outils de recherche et de développement dans les domaines de la biotechnologie et de la médecine. Il a été observé que les modifications des propriétés mécaniques des cellules, telles que les changements de rigidité et de viscosité, peuvent …
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Investigation of the absorption pathways of some poorly absorbed drugs using human intestinal (CAC0-2) cell monolayers
… epithelium is via two pathways; the transcellular and paracellular pathway. Caco-2 cells, when cultured on polycarbonate filters, formed a confluent monolayer with many properties of differentiated intestinal epithelial cells, As a model of human gastro-intestinaJ tract epithelia they were …
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An Investigation of The Use of Dendrimer-Based Carrier to Cross Cellular Barrier
… drug delivery system to overcome the cellular barriers. G3 PAMAM dendrimers were conjugated with lauryl chains via a carbamate bond. Paclitaxel, a low water solubility P-gp substrate and anti-tumour drug, was conjugated to G3 and/or lauryl-G3 PAMAM dendrimer conjugates via a glutaric …
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Single Walled Carbon Nanohorns as Photothermal Absorbers, and Incorporation of Spatial Digital Image Analysis into Cancer Diagnostics and Therapy
… as is the case with standard viability assays of cell monolayers, or they only provide macroscopic treatment information, such as the measurement of the diameters of implanted mice flank tumors post-treatment. Goals: This work aims to accomplish two major goals. The first is to determine the …
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Evaluation of Novel Efflux Transport Inhibitor for the improvement of drug delivery through epithelial cell monolayer
… (CNS) and periphery. In mammals, endothelial cells were shown to be of BBB and are characterized by the tight junctions along with efflux system which are responsible for the restriction of movement of molecules within the cells. Efflux system consists of multidrug resistance proteins such as …
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Host-Parasite Interrelations: Bacterial Adherence to and Invasion of Epithelial Cells
… preferentially invaded multinucleated HeLa cells which arose naturally in monolayer cultures at a low frequency. Data suggests that enhancement of the penetration step accounts partly for increased invasion of multinucleated cells. Treatment of HeLa cell monolayers with polyethylene glycol …
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In vitro cytotoxicity and skin irritation testing of antimicrobial conjugated electrolytes : interactions with mammalian cells
… similar biocidal activity toward mammalian cells. This work examines the toxicity of CPEs to mammalian cells at three levels: cytoxicity testing of cell monolayers, skin irritation testing of tissues, and intracellular co-localization. Eight CPEs, two PPEs and six OPEs, were selected for …
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Role of Protein Kinase C Zeta (PKCζ) in Regulation of Epithelial Tight Junctions
… of occludin and ZO‑1 in Caco‑2 and MDCK cell monolayers without inducing cytotoxicity. Reduced expression of PKCζ also resulted in compromised tight junction integrity. Both PKCζ pseudo substrate and reduced expression of PKCζ delayed the calcium-induced assembly of tight junctions. PKCζ …
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Uptake and transport of orally-deliverable drugs across caco-2 cell monolayers:the effect of lipid formulations
… of the Iiposome. formulations towards the Caco-2 cell line, employed to model the epithelial barrier in vitro. Uptake and transport of mannitol, propranolol, glutamine and digoxin was measured in the presence and absence of Iiposome formulations to establish changes in absorption resulting from …
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Development, characterization, and application of a charged particle microbeam for radiobiological research
… radiation response of biological systems on a cellular and subcellular level, particularly in the area of temporal and spatial effects of radiation on in vitro systems. An accelerator-based 750 keV proton source was characterized and integrated into a laboratory-scale device that includes a …
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Nherf1 – New Modifier of Colorectal Cancer Progression
… epithelium into adenocarcinoma. Loss of cell polarity has been implicated as an early event in this process, but the molecular players involved are not well known. NHERF1 (Na+/H+ Exchanger Regulatory Factor 1) is an adaptor protein with apical membrane localization in polarized epithelia. …
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The Effect of Infection with Polyoma Virus on the Protein, RNA, and DNA of Mouse Embryo Cell Cultures
<p>In four separate experiments mouse embryo cell monolayers infected with polyoma virus and uninfected control mouse embryo cells were maintained in Eagle’s Minimum Essential Medium for periods of time ranging from 0 to 168 hours. The cell layers were removed from the glass by trypsinization. …
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Spatial Organization of Multicellular Living Systems
Cells cooperate as groups to achieve functions at the tissue level, and specific structural characteristics emerge from the local organization of neighboring cells. Analogous to classical physics where transformations in the local structure give rise to phases and phase transitions, the changes in …
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Validation of angle-resolved polarized light scattering spectroscopy as a diagnostic tool for pre-cancer detection
… past ten years. The interaction of light with cellular structures brings out information about morphological changes accompanying malignancy at early stages. The virtue of this technique is to extract key morphological information such as size distribution of nucleus and submicron-sized …
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Travelling Wave Analysis of a Nonlinear Diffusion Equation
Cell monolayers are a widely used tool in tumour and tissue repair studies. In many cell lines, cell proliferation is contact-inhibited such that the cell population reaches confluence at long times. Given suitable initial conditions, moving fronts of proliferation and migration can be observed …
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Microdevices for Investigating Pulsed Electric Fields-Mediated Therapies at Cellular and Tissue Level
… to study the consequences of PEFs at the cellular level. These platforms were specifically used to study the effects of PEFs on the permeabilization of the blood-brain barrier for enhanced drug delivery to the brain. Different techniques such as fluorescent microscopy and electrical …
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Engineered Liver and Intestine Platforms for Modeling Physiology and Disease
… most in vitro models utilize immortalized tumor cell lines or de-differentiated primary cell monolayers, failing to recapitulate in vivo functionality fully. Here, we explore the development and functional characterization of coupled intestine and liver models using primary human cells. We then …
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Cell Mechanics: From Cytoskeletal Dynamics to Tissue-Scale Mechanical Phenomena
… dissertation explores the mechanics of living cells, integrating the role of intracellular activity to capture the emergent mechanical behavior of cells. The topics covered in this dissertation fall into three broad categories : (a) intracellular mechanics, (b) interaction of cells with the …
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