Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Cell memory"”.
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Cell Memory and Fate in Human Development
<p>Development of a single cell, the fertilized egg, into an entire organism is a fascinating example of biological organization that gives rise to many forms of multicellular life. Cell-cell signaling is central to development, particularly in organisms such as vertebrates, where embryonic cells …
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Hedgehog signalling in CD8+ T cell memory
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Defining mRNA-generated T cell memory in respiratory viral infection
T cell immune memory provides protective effector mechanisms to restrict pathogen growth upon secondary infection, although the ability of T cells generated by novel mRNA-LNP vaccines to restrict viral infection in currently unknown. To address this, we studied antigen specific T cell memory …
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A novel model system for the study of anti-tumour T-cell memory
… the fate and requirements of longterm persisting memory T-cells can be monitored. Anti-tumour immune peritoneal exudate cells (iPEC) were produced by injecting a subtumorigenic dose of the highly metastatic, ß-gal<sup>+</sup> T-Iymphoma into the ear pinna of syngeneic DBN2 mice, followed by an …
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B cell memory in STAT3 Hyper-IgE Syndrome: Cytokine integration, IgE regulation, and the architecture of human memory B cell subsets
… life-threatening allergic disease. However, the cellular reservoir of IgE memory in humans is incompletely characterised and prior studies have been unable to reproducibly detect human IgE+ memory B cells (MBCs). Individuals with Inborn Errors of Immunity (IEI) shed light on the molecular and …
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K+-Induced Smooth Muscle Calcium Sensitization Requires RhoA Kinase (ROK) Translocation to Caveolae Which Is Inhibited in Non-Neuronal Cell Memory
… smooth muscle contraction by elevating intracellular free calcium ([Ca<sup>2+</sup>]i<sub>)</sub>, while receptor stimulation activates an additional mechanism termed Ca<sup>2+</sup>- sensitization that can involve activation of ROK and PKC. However, recent studies support the hypothesis that …
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HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity
… or the activation/differentiation status of T cells may play a significant role in heterosexual transmission of HIV and subsequent pathogenesis. Elucidation of the mechanisms underlying the persistent recruitment, activation and differentiation of mucosal T cells will give crucial insight into …
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An investigation of memory T cell phenotypes in peripheral blood of Chacma baboons after immunisation with candidate HIV-1 vaccines
… of the current study was to characterise the T cell memory phenotype distribution in peripheral mononuclear cells (PBMCs) isolated from Chacma baboons vaccinated with SAAVI MVA-C/VLP and DNA/VLP prime-boost vaccination regimens by flow cytometry.
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Restoration of cellular immunity in HIV-infected individuals on antiretroviral therapy
… the virus induces multiple defects in immune cells, altering their functional ability to efficiently control HIV itself and other infections. Whilst the widespread implementation of antiretroviral therapy (ART) has led to reduced morbidity and mortality in most HIV-infected individuals having …
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Modulation of CD8+ T Cell Function by Beta2-Adrenergic Receptor Signaling
… upon stimulation, which can modulate immune cell function primarily through the beta2-adrenergic receptor (ADRB2). Our previous work has demonstrated that various subsets of CD8+ T cells have differential expression of the ADRB2 transcript. The role of ADRB2 signaling on the differentiation …
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Development and characterisation of a novel chimeric antigen receptor against LGR5
… pathway, is lowly expressed in some stem cell niches and overexpressed in multiple cancers, including pre-B acute lymphoblastic leukaemia (pre-B ALL), hepatocellular carcinoma (HCC) and colorectal cancer (CRC). LGR5 has thus emerged as a promising therapeutic target and has spurred the …
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Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory
CD8+ T cells curtail the proliferation of intracellular pathogens. However, the influence of the potency of stimulation on the development of CD8+ T cell memory is not clear. Using recombinant Ovalbumin (OVA) expressing intracellular bacteria, Mycobacterium bovis (BCG) which induces muted T cell …
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Tethered Il-15 to Augment The Therapeutic Potential of T Cells Expressing Chimeric Antigen Receptor: Maintaining Memory Potential, Persistence, and Antitumor Activity
… IL-15 to augment the therapeutic potential of T cells expressing chimeric antigen receptor: Maintaining memory potential, persistence, and antitumor activity</strong></p> <p>Adoptive immunotherapy can retarget T cells to CD19, a tumor-associated antigen (TAA) expressed on B-cell malignancies, by …
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HIV Specific B Cell Response in Patients With Broadly Neutralizing Serum Activity
… To characterize the broadly neutralizing memory antibody responses to HIV we cloned 1078 antibodies from HIV envelope binding memory B cells from eight HIV infected patients with broadly neutralizing antibodies. We found that in these patients, the B cell memory response to gp140 is …
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Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
… immunoregulatory pathway for modulating CD8+ T cell responses. This pathway has become an important therapeutic target in cancer and chronic viral infections, where blockade of PD-1/PD-L1 reverses CD8+ T cell exhaustion and improves outcomes. However, it remains unclear how PD-1 pathway signals …
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T Cell Immunosurveillance in Pancreatic Ductal Adenocarcinoma
ABSTRACT T CELL IMMUNOSURVEILLANCE IN PANCREATIC DUCTAL ADENOCARCINOMA Rebecca A. Evans Robert H. Vonderheide The prevailing theory of cancer immune surveillance, as understood from carcinogen-driven mouse models of highly mutated tumors, states that T cell-mediated immune pressure drives a …
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Clonotypic Analysis of CMV-Specific CD4+ T Cells in Human and Nonhuman Primates
… a host via mechanisms of immune evasion. CD4+ T cells are known to play a role in maintaining life-long immunity against CMV; however, the cellular requirements for establishing and maintaining protection against CMV disease have not been characterized. The objective of this work was to …
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Phenotype and function of B cells in children infected with human immunodeficiency vius
… all lymphocyte populations, including the B-cell compartment. Defects in phenotype and function of B cells have been well characterized in HIV -infected adults. However, only a few studies have investigated the effect of HIV on the B-cell compartment in children, and such studies have been …
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Defining the human immune signature following infection with Crimean-Congo haemorrhagic fever virus
… for antibody, serum circulating biomarker and T-cell memory responses. The studies demonstrated that neither IgM nor IgG antibodies were raised to CCHFV antigens in patients with severe disease despite each patient surviving for long enough such that a suitable immune response could have been …
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HETEROGENEITY OF LATENCY ESTABLISHMENT IN DIFFERENT HUMAN CD4+ T CELL SUBSETS STIMULATED WITH INTERLEUKIN-15
… and persists for the lifetime of the infected cell. Even in the presence of an efficacious Highly Active Anti-Retroviral Therapy (HAART) treatment, a pool of latently infected cells persists and reactivates to produce viral particles if antiretroviral therapies are stopped or discontinued. This …
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