Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"Cell marker"”.
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DELINEATING REGULATORY PATHWAYS OF NOVEL CANCER STEM CELL MARKER, DCLK1-S, FOR TARGETING COLON CANCER STEM CELLS
… for the patient and society. Cancer stem cells are believed to be resistant to conventional treatments resulting in relapse of the disease. Targeting cancer stem cells in addition to conventional therapy may result in better outcomes for patients. Colon cancer stem cells express several …
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The role of sphingosine-1-phosphate in the epithelial to mesenchymal transition in cancer cells
… EMT is the mechanism by which an epithelial cell gains the motility to migrate throughout the body by shifting from a stationary epithelial phenotype to a migratory mesenchymal phenotype. The aim of this study was to investigate the role S1P plays in EMT, proliferation and migration in A549 …
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Expression of Aldehyde dehydrogenase (ALDH) in the breast stem cell line D492 and relations to stem cell properties
… enzymes expressed in both normal and cancer stem cells (CSC). CSCs are hypothesized to arise from normal stem cells and acquire a malignant phenotype through series of genetic mutations. Current therapies often fail to eradicate CSCs causing metastatic relapse. Further characterization of mammary …
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Nkx3.2 regulates zebrafish vascular stabilization through recruitment of mural cells
… development where the immature endothelial cell tube gains structural support through the recruitment and adhesion of perivascular mural cells; pericytes and vascular smooth muscle cells (vSMC). When vessels are not well supported by mural cells hemorrhage can occur. Nkx3.2 deficient …
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Fattori prognostici nel melanoma cutaneo e nel tumore mammario associati a caratteristiche molecolari simil-staminali
Nestin (a neuronal stem cell/progenitor cell marker of central nervous system development), vimentin (which is ubiquitously expressed in mesenchymal cells), and the glucocorticoid receptor (GR, which is involved in the immune response, cell proliferation, and apoptosis) have been shown to interact …
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Isolation, Culture and Cryopreservaion of Neural Stem Cell
… filament proteins and a well-known stem cell marker in the neural lineage. The nestin gene consists of four exons and three introns. It has been known that the nestin transgene containing the second intron is sufficient to direct tissue specific expression of the nestin gene in developing …
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The Selection of Aptamers to CD20 and Their Application as Inhibitors of Complement Dependent Cytotoxicity
CD20 is an important oncological B-cell marker. Immunotherapy, using anti-CD20 antibodies, has revolutionized the treatment of B-cell cancers. Aptamers are highly specific DNA ligands, raised to identify virtually any target molecule through an iterative process known as SELEX (systematic evolution …
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GROUP I METABOTROPIC GLUTAMATE RECEPTORS ON SELECTIVE CELLULAR SUBTYPES IN EPILEPTOGENIC MALFORMED CORTEX
… are common causes of human epilepsy. The cellular mechanisms responsible for the epileptic state of cortex remain unclear and a significant portion of these cases do not respond to treatment. Previous electrophysiological recordings in the Jacobs lab in a rat polymicrogyria model indicated …
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Characterization of the pleiotropic effects of the Drosophila gene mushroom body miniature B
… I further demonstrate, using the mushroom body cell marker dachshund, that loss of mbmB function does not affect the early development of mushroom body neuroectoderm and neuroblasts. Additionally, I found the observed delay in growth and reduced viability were not manifested during embryonic …
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Activity-based sensors for reactive aldehydes and their corresponding enzymatic machinery
… active enzyme. Activity-based sensors are also excellent sensors for reactive small molecules with unique chemical reactivity. Here, we report the development and/or progress on activity-based sensors for reactive biological aldehydes and the enzymatic machinery tasked with aldehyde metabolism. We …
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Biology of adult human normal and leukaemia CD133+ stem cells
Recently, CD133 has been used extensively as a marker for identification of stem cells from human normal and malignant tissues. Human normal CD 133+ stem cells are capable of multilineage in vitro and in vivo differentiation providing a novel source of stem cells for regenerative therapy, whereas, …
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The characterisation of Pax3 expressant cells in adult peripheral nerve
… while knowledge of its complex function in cells of adult tissue continues to unfold. Across a variety of adult tissue lineages, the role of Pax3 is principally linked to maintenance of the tissue’s resident stem and progenitor cell population. In adult peripheral nerves, Pax3 is reported to …
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Dissecting the molecular mechanisms of germ cell development in the planarian Schmidtea mediterranea
… of molecular mechanisms involved in germ cell development is limited to classical genetic model organisms and would benefit from studying additional animal models. Freshwater planarian provides a unique system for studying germ cell development: these animals appear to form their germline …
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Outlining a balance-point model of homeostasis in the small intestine of broiler chickens
… in two of the four groups the expression of stem cell gene Olfactomedin 4 was absent from the crypt though other functional genes were found to still be expressed there. Chapter 3 characterized intestinal gene expression following a single challenge of Eimeria acervulina in broiler chickens. …
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Vasculogenic mimicry in bladder cancer and its association with cancer stem cells and human chorionic gonadotropin-beta
… mimicry is the process of formation of tumour cell lined channels for nutrient transportation, independent of typical modes of angiogenesis. However, not much research has been done to investigate the occurrence of vascular mimicry (VM) in bladder cancer or to correlate the presence of VM with …
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The interaction of disulfiram and H2S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth
… ALDH is recently identified as a cancer stem cell marker, facilitating cell self-renewal and tumour-initiating capacity. Hydrogen sulphide (H2S) as a new gasotransmitter regulates various cellular functions by the S-sulfhydration of cysteine residues in target proteins. H2S has also been shown …
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Duchenne muscular dystrophy and extraocular muscle: a potential sparing mechanism with therapeutic implications.
… the role of extraocular muscle (EOM) progenitor cells in sparing the muscles from pathology associated with Duchenne Muscular Dystrophy (DMD). Mouse models of muscular dystrophy and wild type mice were analyzed by flow cytometry and cell culture for the size, heterogeneity and functional …
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Sustained Depolarization of the Resting Membrane Potential Regulates Muscle Progenitor Cell Growth and Maintains Stem Cell Identity in vitro
… the myogenic properties of muscle progenitor cells (MPCs) during in vitro expansion for stem cell therapies and tissue engineering applications. Controlling cell fate for biomedical interventions will require insight on all aspects that influence cellular properties. The resting membrane …
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Preneoplastic hepatocyte hypothyroidism underlies hepatocellular carcinoma progression
Thyroid hormones elicit many cellular and metabolic effects. Most of them are mediated by the thyroid hormone 3,5,3’-L-triiodothyronine (T3) nuclear receptors (THRs), which act as transcription factors. THRs have also been implicated in tumorigenesis, although it is unclear whether they act as …
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