Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2759 for “"Cell lines"”.
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EFFECTS OF LEPTIN ON ESTABLISHED GLIOBLASTOMA CELL LINES
… associated with decreased overall survival. The cellular pathways activated by eustress were examined in glioblastoma cell lines; leading us to examine the use of β<sub>3</sub> adrenergic stimulation to decrease leptin gene expression as a possible novel therapeutic. The role of leptin and …
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Generation and characterization of BAP-deficient cell lines
… the role of BAP proteins in the ER, mouse ES cells deficient for either BAP29, BAP31 or both were generated by a sequential gene targeting approach. Targeted disruption of the BAP31 locus was achieved using a novel type of targeting vector that combines conditional targeting with promoter …
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The mechanism of tamoxifen action on glioma cell lines
… thus, inhibiting gene transcription and cellular proliferation. In vitro studies have shown that Tamoxifen can inhibit the growth of a brain tumour cell lines, but whether the mechanism involves oestrogen blockade remains a matter of some debate. As well as its effect in blocking estrogen …
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Cytochrome P450 mRNA profile in human breast cancer cell lines.
… receptor mRNAs in a series of breast cancer cell lines (BCCs), and secondly to compare this profile with normal breast cells. This was achieved using a qualitative reverse transcriptase-polymerase chain reaction (RT-PCR) to detect mRNA expression of target genes. Results showed that CYP1B1, …
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
<p>Unlike normal cells, cancer cells can grow in low oxygen (hypoxic) environments. Changes in relative oxygen concentration can alter gene expression in tumors to allow for their selective growth. The result of such changes allows the tumor to adapt its cellular metabolism and promote tumor …
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Cytotoxic Effects of Ruthenium Compounds on Human Cancer Cell Lines.
… compounds appear to be less toxic to healthy cells than traditional platinum-based compounds. In this study, 7 ruthenium-based compounds were tested on HT-29 (colon) and MCF-7 (breast) human cancer cell lines with the specific aim of determining whether or not any of the ruthenium-based …
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Glycosylation of Prostate Cancer Cell Lines and Glycosyltransferase Characterization and Inhibition
… of cancer and can be used to distinguish cancer cells from normal cells. This thesis shows a comprehensive study of glycosylation on a variety of human prostate cell lines. Cell surface glycans were analyzed using lectins and antibodies. Glycans were also released from glycoproteins, purified and …
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Chemical characterisation of grapevine waste and bioactivity on cancer cell lines
… solvent extracts were determined using the non-cellular assays, DPPH and phosphomolybdenum assay. In general red skin and stem extracts had a higher phenolic, flavonoid and total antioxidant activity than white skin and stem extracts, with no significant difference between red and white cultivar …
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Characterisation and modulation of drug resistance in lung cancer cell lines
… It can result from an increase in levels of cellular drug efflux pumps such as P-glycoprotein (P-gp). Using cellular models, this thesis aimed to investigate resistance in lung cancer cells while developing siRNA and membrane proteomic techniques and to increase our knowledge of the effect of …
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Identification of Trim24 Domain Essentiality In Primary Trim24Coe Carcinosarcoma Cell Lines
… capacity on immortalized mammary epithelial cells when overexpressed. Although TRIM24 is a highly promising target for its therapeutic potential with its previously discovered domains facilitating several different functions, it is still elusive which of its domains are essential for its …
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Controlled Myogenic Differentiation of Mammalian Cell Lines by Temperature-Inducible Systems
… vitro generation of skeletal muscle tissue from cell lines is pivotal for the advancement of cultivated meat production. Here, we introduce a novel system employing a synthetic temperature-sensitive promoter (HSP70) carrying multiple heat shock elements (HSE), whose activity can be modulated by …
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Integration of Multiple Data Types for Analysis of Cancer Cell Lines
Cancer cell lines play an important and critical part in oncology research. The advances in understanding of cancer biology which were achieved in the last few decades would be virtually impossible without using cancer cell lines as research models. Therefore better understanding of molecular …
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Molecular Basis of Adaptation of Enteroviruses to Different Cancer Cell Lines
… specially designed viruses to kill malignant cells while leaving normal cells unharmed, is currently under intense investigation. Several receptors are up-regulated in cancer cells, including decay-accelerating factor (DAF; CD55) and integrins (αvβ3, αvβ6) and viruses which recognise these …
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JNK regulates Fas receptor mediated apoptosis in prostate cancer cell lines
… does not significantly increase this. Cell lines derived from hormone refractory tumours usually display elevated resistance to many cytotoxic drugs. The Fas receptor is a membrane bound protein capable of binding to a ligand called Fas ligand. Engagement of Fas receptor with Fas ligand …
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Regulation of mitochondrial respiration by LDHB suppression in hepatoma cell lines
… mitochondrial respiratory defects in hepatoma cells. In this study, we aimed to investigate how LDHB suppression is linked with mitochondrial respiratory dysfunction. When LDHB expression was suppressed by siRNA-mediated knockdown, cellular oxygen consumption rate was significantly decreased …
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Screening for apoptosis in breast cancer cell lines using gel electophoresis
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1995.
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