Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"Cell interaction"”.
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Cell Interaction With a Solidifying Interface
Finally, we examine the effect on cell interaction due to varying simulation parameters, and we use this information to define methods that may help to increase cell survival rates. It is interesting to note that many of the methods used in standard cryopreservation protocols increase both the …
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MOLECULAR BIOLOGY OF HEPATITIS B VIRUS DNA-CELL INTERACTION
… expression library constructed from the hepatoma cell line HuH-6 which was screened with a binding site probe derived from EII. Sequence analysis of E2BP revealed 86.6% homology with a rat hnRNP-C c-terminal protein sequence while conformational studies suggest a "helix-loop-helix'' motif as a …
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Innate Immune Responses in the Alternaria-Dendritic Cell Interaction
… asthma, and chronic rhinosinusitis. Dendritic cells are known as the type of antigen presenting cells most often associated with allergic inflammation. In this study, we used mouse bone marrow-derived dendritic cells (BMDCs) as a model to study the ability of A. alternata spores and different …
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Tumor cell-immune cell interaction: A lethal two way street
… ligand expression upon activation through the T-cell receptor and induced apoptosis in Fas+, LSA tumor cells using the FasL-based pathway. However, LSA and EL-4 tumor cells constitutively expressed Fas ligand and killed Fas+ PE-9 CTLs and Fas+, but not Fas-negative (Fas-) activated T cells and …
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Investigation of neuron T cell interaction in central nervous system tuberculosis
… understanding of the CNS immunity; investigate cells targeted for infection, their respective response to infection and interaction with different cell types to the overall protection of the CNS - as accumulating evidence indicates a dynamic neuronal lymphocyte interplay that defines outcomes of …
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Investigating the role of macrophage-epithelial cell interaction in salivary gland regeneration
… CX3CR1+ macrophages home specifically to ductal cells following radiation injury, and that DNA damage is more severe upon the genetic depletion of macrophages compared to radiation alone. In addition, via in vivo analysis and a novel method for ex vivo live imaging, I show that macrophages …
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Investigation of S1P and S1P Signaling in Adipocytes and Adipocyte-Breast Cancer Cell Interaction
… recognized as an active facilitator in the interaction between the tumor and the adipose tissue in the breast. Adipocytes may act as a therapeutic obstacle and can be viewed as a target in breast cancer, as they affect tumor initiation, progression, invasion, and metastasis by changing their …
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Novel Tools for Investigating Microglia Cellular Turnover Kinetics and Microglia-CD4 T Cell Interaction
… population size, contributing to 5-12% of cellular tissue in the mouse brain, depending on brain region. Following injury and under inflammatory conditions microglia undergo microgliosis, a rapid expansion in number and change in activation state. Microgliosis has been observed in multiple …
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Understanding campylobacter jejuni cytolethal distending toxin intracellular trafficking, structure function relationships, and host cell interaction
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-02-04 without embargo terms
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The role of the Vibrio cholerae Type VI secretion system during kin cell interaction, biofilm formation and priority effects
… priority effects and T6SS activity in kin cell interaction, and how this interaction shapes a bacterial niche. Therefore, to mimic the internal spatial restriction in a host we formed biofilms in-vitro, using A1552 kin <em>V. cholerae </em>cells, priority effects as a temporal aspect, and …
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Identifying the mechanism critical for proliferation, apoptosis, and cell-cell interaction in the development of mouse adrenals and gonads
… Steroidogenic factor 1 (SF1)-positive precursor cells. SF1 not only defines the steroidogenic lineages in these organs, but also controls their differentiation. In this thesis project, I used Sf1/Cre transgenic mice to generate different types of knockout models to study the development of …
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Crystal engineering, Bio Pharmaceutics and Cell biology of active pharmaceutical ingredient (drug) nanoparticles. Formation and cell interaction of hydrocortisone and prednisolone nanoparticles.
… nanoparticles. In the second part, cellular uptake of both coated and uncoated nanoparticles by HaCaT keratinocytes cell line was examined and indicated by quantifying the anti- inflammatory effect of nanoparticles on the LPS-induced inflammation. Also, TEM was employed to evaluate …
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Multiscale spatio-temporal modeling of cell population in tissue architecture and drug delivery nanoparticles
… order of magnitudes in time and space. Molecular interaction at lower scale is connected with the higher scale behavior of tissue or organism. Integrating the dynamics and information at different time and space can give a fundamental physiological understanding of the higher level phenomena. But …
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Novel polymer constructs for controlled release and presentation of topographic cues in support of neuronal cells
… will be used as a substrate to enhance nerve cell interaction in vitro. The polymer will be analyzed for the capacity to influence cellular phenotype, including via controlled biomolecular delivery and surface topography. This thesis showed that all these concepts are possible and begins to …
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Identifcation and stablization of a novel 3D hepatocyte monolayer for hepatocyte-based applications
… indicate its monolayer morphology as well as 3D cell characteristics, which make it a promising novel hepatocyte culture model to improve the conventional 2D hepatocyte monolayer culture. Mechanistic studies revealed that the dynamic morphogenesis is mainly regulated by the balance between …
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A cholera model linking between-host, within-host and environmental disease dynamics
… the within host system incorporates the interaction of virus and immune cell interaction with the vibrios. For each subgroup, we discuss the existence and uniqueness of a DFE (Disease Free Equilibrium) by calculation of the Basic Reproduction number R_0, when applicable, and the existence …
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Multi-scale and multi-group modeling techniques applied to Cholera and COVID-19
… dynamics incorporate virus and immune cell interaction with the vibrios. One model is presented to incorporate all three of these dynamical components. This model is extended to consider the case of a sub-divided population interacting in a spatially heterogeneous environment. In …
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Cell migration and alignment on mechanically controlled environment
… effect of mechanically controlled environment on cell migration and alignment in vitro. Understanding such behaviors are necessary to study wound healing of life, metastatic of cancer cells, tissue engineering, and regenerative medicines. First study is a cell migration behavior on stiffness …
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Inflammasome-Independent Interleukin-1 Beta Drives CD4 T Cell Effector Function and Autoimmune Inflammation
… immunity is a result highly orchestrated interactions between the innate and the adaptive arms of the immune system. Innate immune cells sense the infectious threat to the host and convert it into meaningful information that is relayed to T and B cells. This relaying of information is the …
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TimiGP: A Computational Framework to Determine the Tumor Immune Microenvironment Associated with Prognosis and Immunotherapy Response
… to address this challenge. Leveraging single-cell RNA-seq (scRNA-seq) and bulk gene expression data alongside clinical information, TimiGP constructs a cell-cell interaction network that elucidates the relationship between immune cell function and relevant clinical outcomes, such as prognosis …
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