Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"Cell fates"”.
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Hypoxia signalling regulates human lung epithelial cell fates
… differentiated towards multiple airway cell types, and simultaneously inhibited alveolar differentiation. Time-series single-cell transcriptomic analysis revealed unexpected organoid heterogeneity and delineated hypoxia-induced differentiation processes. The self-renewing organoids under …
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Pioneer Factors Compete for Epigenetic Factors in Switching Stem Cell Fates
<p>During development, progenitor cells can activate one cell fate while simultaneously silencing another, a process that is tightly regulated in adult tissues. However, this process is often derailed in diseases such as cancers, leading to uncontrolled growth and malignancy. At the crossroads of …
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Studying the Patterning Mechanisms and Cell Fates during Limb Regeneration in Ambystoma mexicanum
We studied patterning mechanisms and cell fates during limb regeneration in the axolotl. 1) It is crucial to understand the earliest events of patterning. Since it is technically challenging to study early events, we established single cell PCR. This new tool will allow us to obtain novel insight …
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SGK196 controls stem cell fates by promoting the degradation of TGFβ family receptors
… the molecular mechanisms controlling stem cell fate. Through studies in human pluripotent stem cells (hPSCs), I have identified SGK196, an atypical kinase of relatively unknown function, as a novel regulator of cell fate and the TGFβ family signaling pathway. SGK196 depletion in human …
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Asymmetric localization of prospero and numb specifies cell fates in the Drosophila CNS
… biology is how can two genetically equivalent cells become different? Nowhere is this question more compelling than in the case of sibling cells, where each is derived from the single division of a parental cell. This thesis identifies two proteins involved in generating differences in sibling …
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The synthetic multivulva genes and their suppressors regulate opposing cell fates through chromatin remodeling
… (synMuv) genes act redundantly to inhibit vulval fates in Caenorhabditis elegans. These genes are grouped into three classes called A, B and C. The class A genes encode putative transcription factors. The class B and C genes encode presumptive transcriptional repressors and chromatin-remodeling …
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Cell Size Control And Asymmetric Cell Fates In Start Of The Saccharomyces cerevisiae Cell Cycle
… mechanisms that couple the process of cell growth to cell division is one of the major challenges of modern cell biology. Saccharomyces cerevisiae (budding yeast) has been an important model organism to study the coupling between cell growth and cell division. The insights obtained from …
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Mapping Human Liver Development using Single-Cell Transcriptomics to Reveal Pathways Directing Stem Cell Fates
… with non-parenchymal cholangiocytes, endothelial cells, Kupffer cells, and hepatic stellate cells. Disorders affecting hepatocytes are life threatening and increasing in prevalence12, with end-stage treatment relying upon a limited supply of liver donations for transplant. Consequently, the …
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The Effects of Angiogenic Growth Factors on Mesenchymal Stem Cell Proliferation and Differentiation to Vascular Cell Fates
<p>Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into several cell lineages, including mural cells, which surround and support blood vessels, and possibly endothelial cells, which form the blood vessel walls. In this study, we investigated the effects of basic …
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Delineating mechanisms which underlie differential cell fates induced by p53 activation and HDAC inhibition in colorectal cancer
… for inducing p53 stabilisation within the cell. Strategies aimed at reactivating latent wild-type p53 in such tumours therefore hold enormous clinical potential. This led to the development of small molecule inhibitors of the E3 ubiquitin ligase, MDM2, which normally targets p53 for …
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Mosaic Analysis with Double Markers (MADM) as a Method to Map Cell Fates in Adult Mouse Taste Buds.
… embedded in the oral epithelium composed of cells that undergo continuous replacement. Mature taste cells live on average 10-14 days and are replaced by new cells when they die. However, the mechanism by which taste cells are produced and integrated into the taste bud as mature taste cells …
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The Genome-Wide Roles of The Lung Lineage Transcription Factor Nkx2-1 In The Regulation of Opposing Cell Fates In Vivo
… mark, promote, and maintain multiple distinct cell types originating from a common progenitor. Despite their essential role, how such factors function and bind genome wide to orchestrate the epigenetic changes necessary to form and maintain these identities in vivo is unclear. One lineage …
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The rhinoceros gene of drosophila restricts cell fate specification in the developing eye
Inductive signaling between cells in the developing eye of Drosophila is very important for establishing the correct number and identity of cell fates. Among the signaling pathways that regulate cell fate determination in the developing eye, RTK/Ras/MAPK is among the most important. One effect of …
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The physics of cell-fate choice
Multicellular organisms are composed of many different cell types. All such cells arise from a single cell--- the zygote--- and acquire the various cell fates seen in adult organisms. The different cell types are characterized by distinct, cell-fate-specific gene expression patterns. Cells of …
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Quantitative analysis of the T cell receptor signaling network in response to altered peptide ligands
… and selectivity. In particular, the T cell branch of the immune system is trained to distinguish between self and non-self. This requires that a single receptor, the T cell receptor, bind to multiple ligands resulting in different cell fates, based in part on the avidity of the ligand. …
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Role of Sonic Hedgehog in Development of the Central Nervous System
… the central nervous system (CNS) and specifies cell fates of spinal motor neurons. Shh has also been known to promote cell cycle progression of embryonic stem cells as well as adult neural stem/progenitor cells. However, it has not been elucidated how Shh induces neural induction during early …
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Cue, signal, response analysis of murine embryonic stem cell differentiation : multivariable analysis of cytokine and ECM effects on commitment to differentiation
The highly complex nature of developmental cell fate decisions is exemplified by murine embryonic stem cell (ES cell) differentiation, for which almost two decades of study has identified a small set of putative individual molecular cues which are difficult to generalize broadly or discern …
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Modularity in Somatic Cell Reprogramming
Reprogramming relies on the concept that cellular fate is plastic, and therefore a considerable effort has been made to develop molecular strategies that reset the epigenome to achieve distinct cell fates, including stem cells. Deriving induced pluripotent stem (iPS) cells has thus emerged as a …
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ONTOGENESIS OF MURINE NEURAL CREST DERIVATIVES
… axis-giving rise to many different cell types. The key difference between cranial and trunk neural crest is the ability of cranial neural crest to give rise to mesectoderm. However the origin of mesectoderm has not been unequivocally proven. Furthermore the issue of whether neural …
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Modeling of gene regulatory networks controlling cell-fate decisions in Bacillus subtilis
To adapt to various environments, bacterial cells can activate distinct gene-expression programs and differentiate into mutually exclusive cell types. This process is called cell-fate decision. Bacillus subtilis is a well-studied model system for investigating bacterial cell-fate decisions. In …
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