Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Cell fate decision making"”.
-
Dynamics of Cell Fate Decision Making Between Sporulation and Competence in Bacillus Subtilis
During multipotent differentiation cells must reliably make a cell fate decision under a variety of conditions, yet remain sensitive to changes in extracellular environment. It is unclear how the cells reconcile these seemingly contradictory requirements. To complicate the issue, the cells often …
-
Mechanisms of Genome Buffering and Cell Fate Coordination in Adult Tissue Homeostasis
Self-renewal competency of adult stem cells is essential for tissue homeostasis. The corruption of genes essential for genome preservation or for niche-stem cell interactions frequently results in loss of stem cell viability and disease. The two components of my thesis focus on understanding adult …
-
Interplay between interkinetic nuclear migration and cell fate determination in the developing zebrafish retina
… and directly imaged. All main retinal cell types are derived from multipotent retinal progenitor cells (RPCs), whose clonal sizes and compositions are stochastically determined. However, the biological processes that contribute to the stochastic cell fate decision making of RPCs remain …
-
Pattern Formation During Extensive Cell Movements
… which impart spatial coordinates to individual cells. These coordinates then inform the cell of its respective fate, and hence a pattern of gene expression with spatial organisation is generated. This way of thinking about the problem of pattern formation has been highly successful in explaining …
-
Theoretical and Computational Studies on the Dynamics and Regulation of Cell Phenotypic Transitions
Cell phenotypic transitions, or cell fate decision making processes, are regulated by complex regulatory networks composed of genes, RNAs, proteins and metabolites. The regulation can take place at the epigenetic, transcriptional, translational, and post-translational levels to name a few. …
-
Role of multicellular organisation in mesoderm differentiation
… important for the differentiation of pluripotent cells in vitro and in vivo? During development, pluripotent cell fate decisions are spatiotemporally coordinated with changing tissue architecture. Typically, changes in tissue architecture are thought to be a downstream consequence of changes in …
-
Studying early development using droplet single-cell RNA sequencing
… development is characterised by an increase in cell number and a diversification of the various cell types that are present. Development has been extensively studied not only to understand how cells commit to various lineages, but also with a view to reversing typical developmental pathways for …
-
Assessing the transition state model for cellular differentiation in vivo: a case study of zebrafish neuromesodermal progenitors
During the process of cellular differentiation, stem or progenitor cells undergo a sequence of cell state changes before acquiring the characteristics of their destination fate. The transition state model proposes that a transient window of increased gene expression stochasticity and diversity …