Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Cell engineering"”.
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Expression Analysis and Stem Cell Engineering
… develop tools to advance Investigations of stem cells in tissue engineering therapeutics for neurodegenerative disease and spinal cord injury. Two tools to characterize cell fate and a tool to separate a subset of neural cells were developed and evaluated. In the first study, a digital PCR …
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Harnessing Saccharomyces cerevisiae Genetics for Cell Engineering
Cell engineering holds the promise of creating designer microorganisms that can address some of society's most pressing needs, ranging from the production of biofuels and drugs to the detection of disease states or environmental contaminants. Realizing these goals will require the extensive …
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Convective intracellular macromolecule delivery for cell engineering applications
Efficient intracellular delivery of target macromolecules remains a major obstacle in cell engineering, cell labeling, and other biomedical applications. Current standard methods of intracellular delivery, such as viral transduction and electroporation, do not meet the growing needs in the cell …
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Cell engineering of human bone monolayers and the effect of growth factors and microcontact printed ECM proteins on wound healing. The role of ECM proteins, TGF¿-1, 2 and 3 and HCl/BSA in cellular adhesion, wound healing and imaging of the cell surface interface with the widefield surface plasmon microscope.
… significant evidence that interactions with extracellular matrix molecules also influence cell behaviour. This study aimed at determining the role of the TGF-¿s, Collagen type I, Fibronectin and Laminin in bone cell behaviour. To do this MG63 bone cells were used to examine cell adhesion and …
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Macrophage-hitchhiking Anisotropic Microparticles for Therapeutic and Diagnostic Applications
Cell therapies represent a major paradigm shift of biotechnology in medicine due to its transformative potential in treating previously incurable diseases. A variety of cells have been applied for cell therapies, including stem cells, tissue-specific cells, and hematopoietic cells. Particularly, …
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Transposable elements and the regulatory logic of hematopoietic differentiation
… cis-regulatory elements is central to establish cellular identity and function. Understanding this regulatory logic is critical for deriving select cell types in vitro for translational applications. The human hematopoietic system has long been a model system and an important source for adoptive …
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Engineering VHH-based chimeric antigen receptor (CAR) T cell therapy for solid tumor treatment
Chimeric antigen receptor (CAR) T cells are a promising cancer therapeutic, as they can specifically redirect the cytotoxic function of a T cell to a chosen target of interest. CAR T cells have been successful in clinical trials against hematological cancers, but have experienced low efficacy …
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Catalysts Design and Reactor Engineering for Electrochemical CO2 Capture and Utilization
… I focus on coupling catalysts design and cell engineering to develop CO2 capture technologies and CO2 electrochemical reduction methods. Our research aims to contribute to the mitigation of CO2 emissions, the capture of carbon as a valuable resource, and the promotion of a more sustainable …
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Foundational platform for mammalian synthetic biology
… biology is different from many other biological engineering efforts, in that its roots, design principles, and forward engineering perspective have been adopted from electrical engineering and computer science. Synthetic biology is uniquely poised to make great contributions to numerous fields …
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PEDOT:PSS Enhanced Electroporation for Cell Therapy Manufacturing
Cellular immunotherapies, such as chimeric antigen receptor (CAR) T cell therapies and macrophage therapies, have shown promising results in treating a wide range of cancers. Advances in these therapies focus on increasingly complex cellular systems to simultaneously optimize immune cell …
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Spatial proteomic investigation of monoclonal antibody expression in the Chinese hamster ovary (CHO) cell
… three decades, the Chinese hamster ovary (CHO) cell has progressively established itself as a stable, high yielding mammalian expression system for the production of recombinant proteins – in particular monoclonal antibody (mAb) biotherapeutics. Despite the availability of other platforms, CHO …
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Understanding Development of Human Immunity One Cell at a Time
The emergence of single-cell and spatial multi-omic technologies has revolutionized our understanding of the immune cells. The international Human Cell Atlas consortium has spearheaded and coordinated a global effort to construct atlases of human tissues across multiple developmental stages. This …
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Induced-Pluripotent Stem-Derived Neuronal Progenitor Cells As A Novel Treatment For Neurodegenerative Diseases
<p>Cellular therapies, as neuronal progenitor (NP) cells grafting, are promising therapies for patients affected with neurodegenerative diseases like Creutzfeldt-Jakob Disease (CJD). At this time there is no effective treatment or cure for CJD. The disease is inevitably fatal and affected people …
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Soluble factors and remodeling in a synthetic stem cell niche
Hematopoietic stem cells produce the body’s entire complement of blood and immune cells, in a process known as hematopoiesis. Producing half a trillion cells daily, this rare population (<0.01% of human bone marrow) possess the ability to produce multiple cell lines (differentiation) and stem cell …
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Functional particles for controlled release and cell surface engineering
… emerged as the new generation of molecular and cell carriers for a series of biomedical applications. These polymer vesicles typically present as hollow spheres that contain a hydrophilic core surrounded by a hydrophobic membrane, each of which can be loaded with a wide array of small and large …
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Targeting and translocation mechanisms in the secretory pathway of the yeast Saccharomyces cerevisiae
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:48:18Z Item is restricted indefinitely.
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Machine vision sensing of Ajuga plant cell suspension cultures
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:40:00Z Item is restricted indefinitely.
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Deciphering the Mechanisms of Heterogeneity within Haematopoiesis in Health, Development & Disease
… represents one of the most intricate stem cell processes; in terms of the range of diverse cellular output and the extent of turnover through the system. It also stands as one of the most well characterised cellular systems given the accessibility of the tissue. As our understanding of this …
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Serial protein pairs in cell/surface adhesion
… offers the first systematic investigation of cell/surface adhesion mediated through protein/protein bonds in series. Cell adhesion and migration are facilitated through protein/protein bonds in series established when membrane-bound proteins simultaneously interact with extracellular proteins …
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Adhesion receptor-cytoskeleton interactions in migrating tissue cells
Cell migration is a phenomenon requiring dynamic adhesive interactions between the internal cell motile machinery and the external substratum, with adhesion receptors, such as integrins, serving as the transmembrane link. The goal of this dissertation was to investigate the mechanism by which …
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