Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"Cell dynamics"”.
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Quantifying Intestinal Stem Cell Dynamics Using Microsatellite Sequencing
… renewing throughout life. A population of stem cells exist within the intestinal crypt that drive rapid cell renewal and replace each other by a pattern of neutral drift. Perturbation of these dynamics through oncogenic mutation can predispose the epithelium to neoplastic transformation. …
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A feedback analysis of outer hair cell dynamics
Outer hair cells (OHCs) generate active forces in the mammalian cochlea. Acting as cochlear amplifiers, OHCs can counteract viscous drag, generating high gain at characteristic frequencies and allowing for the sharp frequency selectivity and sensitivity observed in mammals. Excitatory displacement …
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Modeling Neural Stem Cell Dynamics in Congenital Heart Disease
Neural stem/progenitor cells (NSPCs) play a crucial part in the evolutionary development of the human neocortex. During early postnatal development, NSPCs give rise to immature neurons called neuroblasts within the subventricular zone (SVZ) that utilize unique migratory streams to integrate widely …
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New optical techniques and hardware for studying live cell dynamics
… live biological specimens non-invasively at sub-cellular spatial resolutions with high specificity and temporal resolutions. One of the limiting factors of optical microscopy is that the spatial resolution is dictated by the diffraction limit of light.;This work shows the first use of LEDs to …
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Nodal organized cell dynamics for building tissue shapes in vertebrate gastrulation
… form as a result of large-scale collective cell changes. How cell dynamics and mechanics link molecular scale genetic changes to tissue scale developmental outcomes is a major unresolved question in biology. Nodal is a key developmental regulatory gene from the TGF-β family that induces …
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Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
… of cancer-related mortality worldwide, yet the cellular dynamics and molecular mechanisms governing tumour initiation and progression remain elusive. Although alveolar type II (AT2) cells, which act as stem cells in the alveolar epithelium, have been identified as key cells of origin of LUAD, …
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REGULATION OF RHOGAP DLC1 BY FAK, PP2A AND MEK/ERK IN CELL DYNAMICS
… and tumor suppressor, affects the process of cell migration via its regulation of RhoA. A serine-rich multi-domain protein, DLC1 undergoes post-translational modifications such as phosphorylation. It has been identified as a downstream target for various kinases but effects of growth factors, …
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Epithelial and immune cell dynamics in non-traditional models of mammary postnatal development
… epithelial bilayer of luminal and myoepithelial cells. The specific contribution of each distinct epithelial compartment to mammary postnatal development and the mammary microenvironment remains to be elucidated. The present study aims to exploit the ovine and rabbit mammary gland to interrogate …
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Multimodal intravital imaging of tissue structure and cell dynamics in skin using integrated optical coherence and multiphoton microscopy
… microvasculature, collagen networks, single cells and single cell nuclei. In addition to multimodal imaging, technical challenges associated with long-term tracking of the same skin site in vivo are addressed through the development of a non-rigid registration algorithm. For this …
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The role of NEDD9 in TGFβ mediated tumour initiating cell dynamics in the Claudin-low breast cancer subtype
… regulates breast tumour-initiating cells (BTICs). In the claudin-low breast cancer subtype, TGFβ increases the tumour initiating capacity through the ability of the scaffolding protein NEDD9 to unite the TGFβ/SMAD and Rho-Actin-SRF pathways. Previously, oncogenicity has been ascribed …
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Localization and distribution of estrogen receptors and progesterone receptors in the bovine ovary in relation to the cell dynamics
… de aanwezigheid van de steroïdreceptoren en de cellulaire activiteit, met name proliferatie en apoptose. Een laatste objectief was het onderzoeken van de mogelijke correlatie tussen deze parameters en de progesteronconcentraties in het bloedplasma. In het eerste hoofdstuk werd de lokalisatie …
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Mathematical and computational modelling of stochastic partial differential equations applied to advanced methods
… cylindrical pores and spherical pores using Cell Dynamics simulation (CDS) method employed in physically motivated discretization. The lamella, cylindrical and spherical forming systems were studied in the neutral surfaces and the wetting surfaces. To employ CDS method in polar, cylindrical …
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High throughput platform for multiscale quantitative phase imaging
… label-free studies in biomedicine, ranging from cell dynamics and growth to cancer diagnosis and prognosis. The field is currently transitioning from technology-driven to application-driven research and from engineering-background users to biomedical-background users. Aligned with these efforts, …
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Accumulation of Somatic Mutations in Normal Human Colonic Epithelium
I investigated stem cell dynamics in normal human colon by detecting somatic variants affecting X-linked and autosomal genes using immunohistochemistry. Applying neutral clonal marks to a large cohort of patients to interpret age-related trends in clone frequencies has established the baseline stem …
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Cell dynamical system approach to block copolymers
… of block-copolymer (BCP) microphase separation dynamics based on a cell dynamics system (CDS) model. The model suggests a partial differential equation (PDE) model that allows us to find a close relation between the block copolymer and spinodal decomposition problems. A detailed numerical study …
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DEVELOPMENT AND UTILIZATION OF MICROFLUIDIC TRAP (TRYPSIN-BASED RECOVERY AFTER PERMEATION)
Migratory cells in vivo encounter various confining microenvironments throughout the body. In vitro studies of confined migration often use PDMS microchannel devices, but these limit cell extraction for further downstream analysis. Mechanically preconditioning cells with confinement influences …
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Phase imaging with computational specificity for cell biology applications
… built upon the principle of PICS, to detect the cell cycle of live cell clusters. We demonstrate that the proposed method can be applied to study single-cell dynamics within the cell cycle as well as investigate cell biophysical parameter distribution across different stages of the cell cycle.
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Dynamic reconfigurable battery systems via graph-based deep reinforcement learning
… are built from hundreds or thousands of battery cells connected in fixed series-parallel configurations. These rigid topologies limit efficient power management, making it difficult to respond to dynamic cell imbalance and thereby reducing overall battery operating time. To address these …
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DEVLOPEMNT OF FLUORESCENT IMAGING TOOLS FOR LIVE CELL IMAGING
… there is a growing interest to understand cellular processes and behaviors in real time. Fluorescent live cell imaging presents an appealing approach to learn about cell dynamics and function by providing specificity and high resolution. However, one of the biggest limitations of these …
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Mesoscale modelling of block copolymer systems
… computer simulation. In the course of the work Cell Dynamics Simulation (CDS) was implemented as a computer program and further developed when necessary. The choice of CDS is due to the fact that it is a simplest minimal model of the Ginzburg-Landau type and its ability to describe complex …
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