Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 568 for “"Cell differentiation"”.
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Hypergravitational stimulation of cell differentiation
… field within biophysics which encapsulates cellular responses to mechanical stimuli. Mechanotransduction is the highly dynamic and varied downstream cellular signalling which is activated through many different modes of mechanical stimulation. Control of stem cell differentiation has been …
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Proepicardial Cell Differentiation During Cardiac Development
<p> Epicardial cells have an emerging role as cardiac stem cells. These cells and their progenitors, proepicardial (PE) cells, have been recently shown to give rise to all resident cell types in the heart. The contribution of PE-derived cells to the development of atrioventricular (AV) valves and …
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MODULATING CELL DIFFERENTIATION WITH PROTEIN-ENGINEERED MICROENVIRONMENTS
… It utilizes biomaterials that mimic native cellular microenvironments and provide environmental cues to induce specific cell responses, including differentiation. Biochemical and biophysical cues modulate cell behavior and direct construction of specific types of tissue. Thus, this work …
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H4K16 acetylation during embryonic stem cell differentiation
… of H4K16ac in differentiating Embryonic Stem cells (ES cells) and chromatin compaction in vivo. I generated a ChIP-seq profile for H4K16ac in undifferentiated ES cells, and after 3 days of retinoic acid (RA) differentiation. This revealed an association of H4K16ac with the promoters of …
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Capturing Complex Microenvironments for Directed Stem Cell Differentiation
… overcome the limitations associated with adult cell sources, which are often restricted by supply or compromised by disease, mesenchymal stem cells (MSCs) have emerged as potential candidates for vascular tissue engineering. While evidence suggests the roles of several factors influencing MSC …
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Regulation and patterning of cell differentiation and pluripotency
The development of a multicellular organism from an embryo is one of the nature's most remarkable phenomena. Deciphering how this transformation occurs is a fundamental challenge in biology with profound biomedical implications. Insights into the molecular signals guiding developmental patterning …
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Early divergent B cell differentiation during antibody responses
The early B cell response to antigen is analyzed, probing the mechanisms of divergent differentiation into plasmablasts or germinal centre (GC) B cells. Heterozygous QMxB6 mice, in which 5% of B cells are specific for the hapten 4-hydroxy-3-nitrophenol (NP), were immunized with NP-Ficoll. Varying …
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NADPH oxidase in PC12 cell differentiation and apoptosis
<p>Neuronal differentiation is an important process during human development and regenerative medicine. One factor linked to differentiation of neurons <em>in vivo</em> as well as <em>in vitro</em> is the generation of reactive oxygen species (ROS). In addition, neurodegeneration is the disease of …
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Engineered N-cadherin substrates for stem cell differentiation
… Certain success was made to modulate neural differentiation of stem cells using soluble factors and cell adhesion matrix properties. These differentiation studies are often dependent on the density of cells plated on the substrate, which implies that there is an important role of …
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Understanding the Dynamics of Embryonic Stem Cell Differentiation
… defining features of mouse embryonic stem (ES) cells are self-renewal and naive pluripotency, the ability to give rise to all cell lineages in the adult body. In addition to being a unique and interesting cell type, pluripotent ES cells have demonstrated their potential for continued …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… significance of transcriptional regulation of Th cells in MS pathogenesis, we investigated the role of the transcription factors T-bet and PPARalpha in the differentiation and effector function of T helper cells in the EAE model. Based on its ability to induce a pro-inflammatory immune response, …
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Rbfox1 Regulates mRNA Translation to Promote Germ Cell Differentiation
Germ cells are the only cells that can give rise to an embryo. During differentiation, female germ cells that will give rise to oocytes form a syncytium called a germline cyst. The mechanisms that regulate germline cyst development remain poorly understood. In Drosophila, germline stem cells (GSCs) …
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BACH2 orchestrates thymic T cell differentiation and functional programming
… is a highly specialised organ required for T cell development and establishing immunological tolerance. It is tasked with maximising the number of foreign antigens which can be recognised by the T cell receptor (TCR) repertoire in order to protect from infection. Simultaneously, the thymus …
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Regulated Histone H3 Proteolysis During Mouse Embryonic Stem Cell Differentiation
… chromatin often lead to dynamic changes in many cellular processes, including development and differentiation, by affecting the accessibility of the genomic information stored in the DNA. The cell uses many different mechanisms to regulate chromatin in order to establish, maintain, and propagate …
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Death by Frustration: How Defects in Cell Differentiation Trigger Apoptosis
… the growth, development, and homeostasis of multicellular organisms by removing excess cells and sculpting tissues. The implications of its misregulation in diseases such as cancer, neurodegeneration, and autoimmunity bespeak of its importance. A family of proteases called caspases brings about …
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The regulation of mouse embryonic stem cell differentiation by Nrf2
Embryonic stem (ES) cell maintenance and differentiation are dynamic processes controlled by various intrinsic and extrinsic factors. Identifying these factors will enhance the understanding about developmental process and improve the application of stem cells in clinic. Previous studies highlight …
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Notch signaling pathway in human vascular smooth muscle cell differentiation
… studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to mechanical stimuli. VSMC differentiation is a crucial developmental process regulating angiogenesis and vasculogenesis, with phenotypic modulation of SMC …
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Role of Endoplasmic Reticulum Stress in Trophoblast Stem Cell Differentiation
… of endoplasmic reticulum (ER) stress on the differentiation of trophoblast stem cells (TSCs), placental development, and subsequent pregnancy outcome. To address this question, I first used an in vitro mouse TSC model. Morphological observations suggest that upon ER stress, TSCs lose stemness …
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