Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Cell cycle re-entry"”.
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Bmp proteins in urodele myotube cell cycle re-entry and in regeneration
Urodele amphibians have the remarkable ability to re-grow lost body parts. This regenerative response after injury in urodeles involves dedifferentiation of fully differentiated cells into proliferative cells. One well-studied example of this is the dedifferentiation of multinucleated muscle cells …
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Purification of A Serum Factor That Triggers Cell Cycle Re-entry In Differentiated Newt Myotubes
… to mammals, some fish and amphibians have retained the ability to regenerate complex body structures or organs, such as the limb, the tail, the eye lens or even parts of the heart. One major difference in the response to injury is the appearance of a mesenchymal growth zone or blastema in …
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Crosstalk between E2F3 and p19ARF/p53 in the regulation of cell cycle progression and tumorigenesis
… identified as a critical component of the cellular machinery responsible for promoting cell cycle progression that is co-opted during transformation and tumorigenesis. Classic E2F target genes have functions required for S-phase entry and progression. However, the role of E2F has expanded …
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Myc and Cyclin T1 co-expression as a therapeutic strategy for cardiac repair following myocardial infarction
Background and Aims The inability of the heart to regenerate itself by promoting endogenous cardiomyocyte proliferation after myocardial infarction (MI), leads to scarring, cell hypertrophy, and loss of contractility in the left ventricle. Driving endogenous cardiomyocyte proliferation is a …
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p53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's Disease
… factor, p53, is critical for many important cellular functions involved in genome integrity, including cell cycle control, DNA damage response, and apoptosis. Disruption of p53 results in a wide range of disorders including cancer, metabolic diseases, and neurodegenerative diseases. …
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Leveraging cellular models of polycystic kidney disease for mechanistic discovery and therapeutic development
Polycystic kidney disease (PKD) is a life-threatening disorder characterized by the progressive expansion of fluid-filled cysts originating from kidney tubules. As the leading monogenic cause of renal failure, PKD affects 1 in ~1,000 people with 50% of patients meeting criteria for end-stage renal …
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The function of E2F6 in the Polycomb complex
The E2F family of transcription factors are known cell cycle regulators that function at the G1/S transition. Unlike other E2Fs, E2F6 does not activate transcription and is not regulated by pocket protein binding. Instead, this protein appears to repress transcription through the recruitment of the …
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OVERT AND LATENT PATHWAYS OF POLARITY SPECIFICATION IN ZYGOTES: THE HAPLOID-TO-DIPLOID TRANSITION
… asymmetry is fundamental for normal differentiation and function of diverse cell types, from unicellular prokaryotes to multicellular eukaryotes. Polarity specification, the establishment of an axis for directed growth and secretion, allows cells to achieve anasymmetrical state. This …
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MEF2-regulated Gtl2-Dio3 noncoding RNAs in cardiac muscle and disease
The MEF2 transcription factor is a central regulator of skeletal and cardiac muscle development. Recently, we showed that MEF2A regulates skeletal muscle regeneration through direct regulation of the Gtl2-Dio3 microRNA mega-cluster. In addition to their expression in skeletal muscle, temporal …
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Towards an understanding of the role of Ca2+ signalling in neural stem cell activation
Regeneration of the adult human brain is a long time clinical challenge. The adult mammalian brain contains neural stem cells (NSCs) that are capable of brain repair, but they are mostly in a mitotically quiescent state. Identifying novel regulators of neural stem cell quiescence will provide more …
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Mechanical modulation of indirect repair mechanisms for improved hematopoietic recovery
Hematopoietic stem cell or bone marrow transplantation is a curative treatment for multiple hematologic malignancies. However, the myeloablative conditioning regimens preceding cell delivery have rendered the rapid and sustained hematopoietic recovery after transplantation an outstanding challenge. …