Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"Cell behaviour"”.
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Cancer cell behaviour following parasite exposure
… cancer development and progression, or which cellular mechanisms are altered following exposure. Using several in vitro and in vivo techniques, this study aimed to determine the effect that certain helminths have on the progression of cervical and colorectal cancer. The results revealed that …
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Cell cycle perspectives on breast cancer cell behaviour
… important characteristics of aggressive tumour cells. Previous observations in both colorectal cancer and basal cell carcinoma indicated that infiltrative tumour cell behaviour might be counteracted by a high proliferative activity, suggesting a coordination of these two activities at the …
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Cell behaviour during optic vesicle morphogenesis in medaka
… optic vesicle morphogenesis and its underlying cellular basis were missing. I therefore used an in vivo imaging approach in medaka fish to investigate the cellular movements and dynamics of early eye formation. Early medaka embryos were not amenable to in vivo imaging due to contractile …
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Imaging innate immune cell behaviour in lymphoid organs
Innate immune cells generate the early host response to infection and tissue injury. Neutrophils are rapidly recruited from circulation to inflammatory tissues for pathogen killing. Type 2 innate lymphoid cells (ILC2s) mediate early responses to helminths and allergens via cytokine production. …
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Studying the direct effects of forces on embryonic stem cell behaviour
Cells experience different mechanical cues from their local environment, including shear flow, forces applied by neighbouring cells, and substrate stiffness. These external signals influence cell behaviour, also in embryonic stem (ES) cells, where they could potentially affect pluripotency or …
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ADAMTS1 is a promoter of metastatic cell behaviour in mammary cancer cells.
… is characterised by the dissemination of cancer cells from the primary site, infiltration into vessel networks and the establishment of new tumour growth in secondary tissues. Several events are required for metastasis to occur, including enhancement of cell-matrix adherence, augmented motility …
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Local Wnt11 Signalling and its role in coordinating cell behaviour in zebrafish embryos
Wnt11 is a key signalling molecule that regulates cell polarity/migration during vertebrate development and also promotes the invasive behaviour of adult cancer cells. It is therefore essential to understand the mechanisms by which Wnt11 signalling regulates cell behaviour. The process of …
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The role of the tumour microenvironment components in cancer cell behaviour and drug response
… investigated the interactions between cancer cells and the stroma within the TME, specifically fibroblasts, mesenchymal stem cells (MSC), cancer stem cells (CSCs) as well as the extracellular matrix (ECM), with the goal to develop an in vitro model that mimics solid tumours in terms of …
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Investigations into the roles of Histamine Receptor H1 and extracellular vesicles in ovarian cancer cell behaviour
… H1 (HRH1) by histamine stimulates growth of OC cells in vitro and promotes the release of extracellular vesicles (EVs) in different cell lines. EVs are heterogeneous small vesicles involved in intracellular communication, which also modulate various steps of the metastatic process. The main …
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Architectural, mechanical and biochemical control of collagen films and scaffolds to guide neural- and fibroblast cell behaviour
… gaps in damaged nerves via infiltration of cells along oriented pore structures which can guide sprouting axons and direct Schwann cell migration. Neural cells have been shown to be highly mechanosensitive and hence substrate stiffness is an important factor in the repair process. However, …
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Evaluating the use of laser processing and polishing techniques to generate micro-patterned surfaces for controlling fibroblast cell behaviour
… (LL24) and bovine aorta endothelium (BAE-1) cell behaviours. The cells ability to adhere, proliferate and migrate were studied through the use of MTT assays and live cell tracking. Laser processing in a directional manner resulted in polyurethane surfaces having a ploughed field effect with …
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Verfahren zur Herstellung gefriergetrockneter Kollagenschwämme mit definierter Porenstruktur
… structure of the collagen sponges influences cell behaviour. Until now, this influence could not be investigated systematically, since the pore structure of commercially available collagen sponges is very unregular. Therefore, a new freeze-drying process for manufacturing collagen sponges with …
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The origin and properties of pro-oncogenic fields in the intestinal epithelium
… epithelium is maintained by intestinal stem cells that replace each other stochastically over time. Stem cells that are excluded from the stem cell pool will differentiate into the absorptive or secretory cell lineages. However, intestinal cell-fate specification is not always restrictive and …
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Cellular responses to potential biomaterials
… to be responsible for anchorage-dependent cell behaviour to determine which, if any, of these factors exerts greater influence. An efficient means of doing so is the in vitro fibroblast cell culture model. The interaction of fibroblasts with novel substrata gives information about how a …
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Aligned Fibrillar Collagen Matrices for Tissue Engineering
… production of ordered substrates that orient cells preferentially and support cell viability and differentiation. Towards this goal, this thesis investigated methodologies to align extracellular matrix structures in vitro to guide stem/progenitor cell behaviour for tissue regeneration. Aligned …
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Multi-scalar mechanisms timing axial progenitor contribution to the vertebrate body axis
… mechanisms that control the absolute timing of cell state changes and morphogenetic events in development are largely not understood, and crucially can be considered at a wide range of length scales, from the integration of positional cues over time in a single cell to whole-organism events such …
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The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines ©
… bone because of their ability to activate intracellular signal cascades leading to altered cancer cell behaviour and bone breakdown. The JAK/STAT5a cell signaling pathway is also crucial to breast biology and is involved in transcriptional regulation of many genes. The objective of this study is …
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REDOX HOMEOSTASIS IN THE DROSOPHILA TESTIS STEM CELL SELF-RENEWAL AND MAINTENANCE
… fundamental biological processes such as stem cell maintenance. However, aberrant ROS levels lead to oxidative stress, which is highly associated with various human diseases such as cancer and aging. Here, I examined the effects of redox states on stem cell maintenance, and identified the …
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Defining Epithelial Cell Fate Dynamics of the Oesophagus during Postnatal Development and Homeostasis
Epithelial cells can respond rapidly to changing tissue demands to ensure organism survival. However, the mechanisms that finely control how cells adapt their behaviour remain largely unknown. To uncover the rules that govern epithelial cell fate, it is critical to understand their dynamic nature …
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The Influence of Structure and Surface Biochemistry on Cell Function and Angiogenesis in Collagen Scaffolds
… survival including the supply of nutrients to cells and waste exchange. Therefore, in order to prevent core degradation of tissue-engineered grafts, it is important to provide appropriate physico-chemical conditions to encourage angiogenesis in the period immediately following implantation. …
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