Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Cell based therapy"”.
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Stem cell based therapy of malignant brain tumors
… and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. The aims of the present thesis have been to develop and explore a stem cell based vector system for delivery of …
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Towards hES cell-based therapy of Epidermolysis Bullosa
… approaches to generating keratinocytes (the main cell of the outer skin layer, epidermis) from pluripotent stem cells (human embryonic stem cells, hESCs). Undifferentiated hESCs were exposed to a complex microenvironment in organotypic cultures (to mimic conditions for epidermal stem cell …
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Production of hepatocytes from human pluripotent stem cells for cell-based therapy
Human pluripotent stem cells (hPSCs) can self-renew indefinitely in vitro while maintaining the capacity to differentiate into diverse cell types, including hepatocytes. Thus, hPSCs allow for large-scale production of hepatocytes necessary for cell-based therapy. Importantly, cell-based therapy …
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Directly induced Neural Stem Cells transplantation and prospects for stem cell-based therapy
… by ongoing neurodegeneration and demyelination. Cell transplantation is among the most promising therapeutic approaches in regenerative medicine, combining tissue trophic and immunomodulatory effects of the graft with its intrinsic potential for cellreplacement. These are all attributes that can …
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Advanced micro/nano-encapsulation: Controlled release of therapeutic agents and cell-based therapy
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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NEURAL PRECURSOR/STEM CELL-BASED THERAPY: A NOVEL THERAPEUTIC APPROACH FOR THE TREATMENT OF RETT SYNDROME
… the possible efficacy of neural precursor/stem cell (NPC) transplantation, that has already been proved beneficial and safe for many neurological disorders, such as Parkinson’s disease, spinal cord injury, ischemia and multiple sclerosis. Mechanisms of action of NPCs can rely not only on the …
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Development of a stem cell-based therapy for the recovery of skeletal muscle mass following immobilization
… rehabilitation is the most commonly prescribed therapy to help recover from disuse atrophy; however, illness and lack of mobility may limit physical activity and full recovery may not be possible, particularly in older adults. Therefore, there is a need to develop novel and more effective …
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Molecular mechanisms of T cell homing in Hodgkin's lymphoma : implications for T-cell-based therapies
… have seen important advances in the area of T cell-based therapy for human malignancies. Epstein Barr virus-associated tumours like Hodgkin’s Lymphoma provide important models in this field. If a T cell-based therapy is to be effective however, T cells must be capable of trafficking to the …
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INVESTIGATIONS ON POTENTIAL OF UMBILICAL CORD LINING STEM CELLS FOR IN VITRO MODELS
Since their discovery, stem cells have been highly regarded for their potential in applications ranging from bench top studies, pharmaceutical applications to cell-based therapy. In our study, the potential of human umbilical cord lining stem cells (UCLSCs) for in vitro models is investigated in …
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Matrix Metalloproteinases Regulate The Differentiation Of Adipose-Derived Mesenchymal Stem Cells Into Endothelial Cells
Mesenchymal stem cells (MSCs) have a great potential as a source of cells for cell-based therapy because of their ability for self-renewal and differentiation into functional cells. Cell-based therapy that can rejuvenate the endothelium with stimulated adipose-derived MSCs (AMSCs) is a promising …
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APPLICATIONS OF MICROARRAYS AND STEM CELLS FOR REGENERATIVE MEDICINE
Stem cells are viewed as a potential resource for cell-based therapy and regenerative medicine. Understanding the genes that govern the special properties of stem cells has implications for both stem cell biology and regenerative medicine. This information will ensure the quality of the cells, the …
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Potential of endothelial progenitors to reverse choroidal atrophy during age related macular degeneration
… of dry AMD have already proven detrimental to cell survival. To introduce cells into an area suffering from severe oxidative stress may risk exacerbating matters, if the cells are likely to become apoptotic or necrotic and adding to the noxious conditions of the environment. If a cell therapy …
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Cellular and molecular immunotherapeutics derived from the bone marrow stroma
The bone marrow contains a multipotent stromal cell, commonly referred to as a mesenchymal stem cell (MSC). There has been recent interest in the clinical use of MSCs for cell-based therapy because: (1) bone marrow aspiration is a routine method used in medicine thereby allowing for easy …
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Impact of Primary Myoblasts on Macrophage Polarization In-Vitro
… which has been studied as a therapeutic option. Cell-based therapies, such as BM-MNCs, have been investigated as means to enhance arteriogenesis, but have largely failed in clinical trials. An alternative cell-based therapy candidate are myoblasts, or muscle progenitor cells. Myoblasts increase …
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A multimodal lens into vascular recovery in a preclinical model of peripheral arterial disease
… and exploring the therapeutic potential of stem cells to treat vascular complications associated with diabetes. This document is divided into four main chapters. The first chapter describes the biological characterization of two different imaging probes targeted, respectively, at hypoxia and …
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Stem cell matrix and cartilage regeneration
… due to its limited healing capacity. Current cell-based therapy using autologous chondrocyte implantation has been developed for decades and promising results have been observed in clinic. However, the shortage of autologous chondrocytes and their uncertain long-term effectiveness have led …
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Characterization and application of adipose derived stem cells following burn injury
… that modulates signaling in adipose-derived stem cells (ASCs), which hold potential for healing burn wounds or generating skin substitutes. Using a 60% rat scald burn model, we investigated the cellular source of inflammation within adipose tissue and whether inflammation affects ASC fate and …
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Humna fetal neural stem cells: Proliferation and differentiation in response to growth factors and role in locomotor recovery after spinal cord contusion injury
Human fetal neural stem cells (hNSCs) may be useful for developing a cell-based therapy to treat spinal cord injury (SCI). In these studies we examined the effects of epigenetic mitogens on proliferation and differentiation of hNSCs in vitro and the outcome of hNSC grafting into contusion injured …
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Molecular control of embryonic stem cell identity
Embryonic Stem (ES) cells are the in vitro derivatives of the inner cell mass of a developing embryo, and exhibit the property of pluripotency, which is the ability of a cell to give rise to all cell lineages of an organism. Therefore, these cells hold great promise in the treatment of several …
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Organization and differentiation of stem cells on delivery scaffold for retinal tissue engineering
… for these types of disease; however, stem cell-based therapy is a recent strategy which has the potential to preserve and restore vision in these conditions. In addition to replacing lost or diseased cells, transplanted cells may be able to rescue dying photoreceptors of the host retina. …
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