Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 150 for “"Cell and Developmental Biology"”.
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Identification and characterization of estrogen receptor-regulated gene expression programs
… University of Illinois Dissertations and Theses (ID: 204) Dissertations and Theses - Cell and Developmental Biology (ID: 702) No. of bitstreams: 4 Barnett_Daniel.pdf: 1415172 bytes, checksum: 987676a4ebbd90f86f981e2b1fa65c34 (MD5) 1_Barnett_Daniel.pdf: 1417691 bytes, checksum: …
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DEVELOPMENT OF SINGLE-CELL MASS SPECTROMETRY TOOLS TO INVESTIGATE METABOLIC REORGANIZATION DURING EARLY EMBRYOGENESIS
Measurement of metabolism in single cells holds the potential to advance our understanding of fundamental biological processes during cell differentiation and development. However, to characterize the metabolic state of single cells, further technological advances are still required. This …
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The roles of the Robo2 and Robo3 receptors in the development of cortical interneurons and Cajal-Retzius cells
… focuses on the putative roles of the Robo2 and Robo3 receptors in regulating the development of cortical interneurons and Cajal-Retzius cells in the embryonic mouse forebrain. A detailed analysis of the expression patterns of the Robo3 receptor is elucidated for the first time. Further …
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Analysis of the role of the X/Y homologous gene family Xmr/Sly in murine spermiogenesis
Spermatogenesis is a complex, continuous developmental process that involves the formation of highly differentiated haploid sperm from diploid spermatogonial stem cells. Deletion analysis has established that genes on the Y chromosome are essential for normal sperm production in humans, mice and …
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Early liver formation in zebrafish: a molecular and morphological approach
The digestive tract and its accessory organs - liver, pancreas, and the inner lining of the swim bladder - are derived from the endodermal germ layer. In zebrafish the digestive system starts out as a rod at the embryonic midline, which subsequently becomes patterned and outgrowth of its associated …
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Place cell physiology in a transgenic mouse model of Alzheimer's disease
… impairments (Selkoe, 2001). Hippocampal place cells are a well understood candidate for the neural basis of one type of memory in rodents; these cells identify the animal's location in an environment and are crucial for spatial memory and navigation. This PhD project aims to clarify the …
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The Interplay of Signal Transduction and Membrane Traffic of the Macrophage Colony Stimulating Factor Receptor (MCSFR) Controls Macrophage Growth
… that is essential for the growth of myeloid stem cells, monocytes and macrophages. Proper control of signaling through the MCSFR is critical for proper macrophage development and function. Deregulation of this signaling pathway is associated with numerous inflammatory diseases as well as …
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IGFBP-3 blocks hyaluronan-CD44 signaling, leading to increased acetylcholinesterase levels in A549 cell media and apoptosis in a p53-dependent manner
… its cytotoxic effects on A549 (p53 wild-type) cell survival through a mechanism that depends on hyaluronan-CD44 interactions. To shed light on the mechanism employed, we used CD44-negative normal human lung cells (HFL1), A549, and H1299 (p53-null) lung cancer cells. A synthetic IGFBP-3 peptide …
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Expansion microscopy to visualize cell-cycle events in the abbreviated cell cycle in <i>Caenorhabditis elegans</i> (roundworm) germline stem cells
<p>The abbreviated cell cycle is a poorly understood form of the cell cycle essential for genome stability in stem cells. To visualize cell-cycle events in the abbreviated cell cycle, we optimized a protocol for expansion microscopy in stem cells of the reproductive system of the model organism C. …
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EHBP1 and EHD2 Regulate Dll4 Caveolin-Mediated Endocytosis During Blood Vessel Development
… must be tight regulation between a leading tip cell and trailing stalk cells during vascular patterning. Lateral inhibition produced by Notch signaling is central to the specification and maintenance of tip and stalk cells in growing angiogenic sprouts. The Notch pathway is activated by the …
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Molecular and Neural Mechanisms Underlying Courtship Song Evolution in Drosophila
… is encoded by evolutionary changes in genes and neurons is unclear. To fill in this knowledge gap, my colleagues and I take advantage of the diversification of Drosophila courtship songs as a model system to explore the molecular and neural mechanisms underlying species variation in behavior. …
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Effects of acetyl salicyclic acid on Drosophila models of cancer-inflammation
… disease pathologies including diabetes, cancer, and neurodegeneration. Indeed, one of the most commonly-used anti-inflammatory drugs, aspirin, has been shown to be effective in the treatment of many cancers. To understand the mechanistic linkages between inflammation and cancer, we used …
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Characterization of the interaction between FtsZ-ring stabilizer ZapC and the conserved protease ClpXP in E. coli cytokinesis
<p>Cell division in bacteria requires the assembly of a macromolecular protein machinery at midcell that is spatiotemporally regulated during the bacterial cell cycle. Central to the process of division is the assembly of a cytokinetic ring-like structure, termed the Z-ring, formed by polymers of …
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The Resource Environment and Microbial Associations Mediate Adaptation to Environmental Heterogeneity in Drosophila Melanogaster
… remains a major focus of evolutionary biology. The ability to observe the genomic and phenotypic evolution of populations over rapid timescales has enabled a deeper exploration into the role particular environmental variables have on a population’s response to selection. While replicate …
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Purification and Characterization of an Anti-Basigin Monoclonal Antibody: Application to the Study of Human Uterine Cells and Tissues
<p>Between 1990 and 2017, the global rate of female infertility increased by over 15% (Sun et al., 2019). An embryo's failure to implant into the uterus is the primary cause of early pregnancy loss. Several studies have identified molecules necessary for successful implantation, but their function …
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Expression and Function of a Putative Cox-Like Gene in D. melanogaster
… the conversion of arachidonic acid into prostaglandins. In mammals, isoform COX-1 is constitutively expressed, whereas the isoform COX-2 gene expression is induced, primarily at sites of inflammation. While eicosanoids play a major role in inflammation in insects, their existence in fruit flies …
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Screen for Suppressors and Enhancers of Excitotoxic Neurodegeneration
<p>Excitotoxicity is an important and frequently observed neurodegenerative process. Excitotoxicity mediates brain damage in a range of diseases and conditions including stroke, and is triggered by excessive stimulation of glutamatergic synapses. In spite of extensive studies, the molecular …
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Notch Signaling Is Important in the Survival, Proliferation, and Self-Renewal of the Putative Breast Cancer Stem Cell Population
<p>Numerous studies have identified stem-like cells, termed cancer stem cells (CSCs), in breast tumors and established cell lines. It has been hypothesized that CSCs are responsible for breast cancer formation, progression and recurrence; therefore, a deeper understanding of the signaling pathways …
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