Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Cell ablation"”.
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Development of an Optogenetic Tool for Targeted Sensory Hair Cell Ablation in Zebrafish
Mechanosensory hair cells convert mechanical information into neuronal signals. Mutations in the genes required for hair cell function cause deafness and lead to the degeneration of sensory hair cells. Mammals are unable to regenerate these cells, leading to the permanent loss of hair cells. …
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The regulation of tissue proportions: analysis of progenitor behavioural dynamics in response to cell ablation in the zebrafish tailbud.
… a correctly patterned embryo the behaviour of cell populations and tissues must be coordinated so that different structures form with the correct relative proportions. The fundamental body plan of the vertebrate embryo is laid down in a head to tail progression known as primary body axis …
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An inducible, conditional and targeted B cell ablation mouse model for studying B cell functionality in the pathogenesis of human diseases
… project is to characterize and develop a B cell ablation model for investigating the pathogenesis of human diseases such as hepatitis and systemic lupus erythematosus (SLE). Conditional and targeted cell ablation is a powerful approach for studying cellular functions in vivo. However, …
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An Examination of the Roles of CX3CR1 and Microglia in a Mouse Model of Degenerative Cervical Myelopathy
… of surgical decompression. As resident immune cells of the CNS, microglia play significant roles in the response to injury, but they have yet to be investigated after decompression. Further, as a major mediator of microglial activation, CX3CR1 represents a key target to understand and …
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Damages in Transparent Materials by Ultrashort Laser Pulse
… fabrication to bio applications such as cell ablation. The fundamental aspects of ultrashort pulse material interaction are still remaining an active research topic. Here, we focus on the investigation of how ultrashort pulses, particularly picosecond laser pulses, interact with the bulk …
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Synaptic Specificity in the Zebrafish Lateral Line
… of larval zebrafish consists of polarized hair cells organized in discrete clusters known as neuromasts. Here I show that each afferent neuron of the posterior lateral line establishes specific contacts with hair cells of the same hair-bundle polarity. I quantify this specificity by modeling the …
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Effects of Homocysteine on Cardiac Neural Crest Cell Formation
… many of which resemble neural crest (NC) cell ablation. However, the etiological mechanism is not known. The purpose of this study was to determine if Hcys altered the number and/or the proliferation of NC cells or their progenitors /?? Uw. Hcys was experimentally elevated in chicken …
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Overcoming therapeutic resistance in glioblastoma using novel electroporation-based therapies
… GBM therapeutic resistance. Furthermore, tumor cells are sequestered behind the blood-brain barrier (BBB), limiting delivery of effective therapeutics and immune cell infiltration into the local tumor. Electroporation-based therapies, such as irreversible electroporation (IRE) and second …
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Molecular and Genetic Analysis of Neuropeptide Signalling in Mammalian Circadian Timekeeping
… pacemaker, co-ordinating the multitude of cell-autonomous circadian oscillators across the body to ensure internal synchrony, as well as maintaining an adaptive phase relationship with the light-dark cycle via projections from the retina. Intercellular communication between SCN clock …
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Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation
… must be controlled to limit immunopathology. Cell-intrinsic effects of inhibitory and signaling molecules are known to maintain quiescence and prevent effector differentiation and inflammation. Moreover, specific populations of immune cells exert cell-extrinsic effects for immunosuppression. …
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Molecular Mechanisms of Itch Sensations
… itch-specific receptor in the spinal cord. GRPR cell ablation by bombesin-saporin abolished general scratching responses to pruritogens. Because GRPR mutant mice still have remained itch responses, it is possible that additional itch mediators are present in the spinal GRPR neurons. Differential …
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Recall Germinal Center and Antibody Responses
… response is a result of the recall of memory B cells (MBCs) that have undergone clonal expansion and affinity maturation in germinal centers(GCs) during the primary response. Upon antigen re-encounter ("boosting"), MBCs, aided by enhanced help from memory T cells, efficiently differentiate into …
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Investigating the Effect of Antibody-Mediated Feedback on Ongoing Germinal Center Responses
… titers, which requires the participation of B cells in the germinal center (GC) response. It is well-established that pre-existing antibodies can influence the outcome of future humoral responses; however, whether antibody from an ongoing response can feedback onto contemporaneous GCs to …
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Liver fluke development: a target for parasite control?
… have identified a population of proliferative cells within Fasciola hepatica (Fasciola proliferative cellsFPCs) that resemble neoblast-stem cells, both morphologically and behaviourally. These cells are the only proliferating cells in Fasciola hepatica and can be localised using thymidine …