Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1471 for “"Cell Types"”.
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Collective Dynamics of Interacting Cell Types
… pronounced in the context of complex multicellular organisms, where single-cell technologies allow us to dissect tissue heterogeneity at the level of individual cells. For the theoretical sciences, this wealth of data provides a unique opportunity to synthesize general principles that unify …
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Tissue-specific adaptations of cell types
Cells are the building blocks of life, forming the vast diversity of tissues and organisms in Nature. Across these, common cellular morphologies and functions have been identified. High-throughput, multifactorial profiling of cells has grown exponentially in recent years with the advent of …
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Deep Molecular Characterization of Human Cortical Cell-Types
… functionally, and molecularly distinct cell-types, the neocortex is organized into cytoarchitectonically and functionally diverse regions. In concert, the diverse cell-types that are found within the diverse cortical regions build the center of all higher cognitive functions, including …
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Cells that Kill: The Chemosensory Cell Types of Aedes aegypti Mosquitoes
… molecular underpinnings of mosquito chemosensory cell types. In olfaction, research following the cloning of the first odorant receptors in1991 has shown that each mouse olfactory sensory neuron (OSN) expresses a single odorant receptor. Early work in Drosophila melanogaster flies reported a …
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MUTAGENESIS OF AAV CAPSID PROTEINS FOR ENHANCED TRANSDUCTION OF CARDIAC CELL TYPES
… tissue, and the eye, versus other AAV serotypes. Unfortunately, nonspecific targeting to the intended tissue can result in the need for use of higher particle numbers to obtain intended transduction of the target tissue, which may also increase chances of initiating innate and adaptive …
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Mass spectrometry-based investigations to characterize specific cell types within the brain
… content of the brain and its many constitutive cell types yield information regarding normal and abnormal brain function. Frequently, proteomics, peptidomics, and metabolomics experiments survey brain regions and attribute detected species to neurons. However, many other cell types are present, …
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Using molecular QTLs to identify cell types and causal variants for complex traits
… trait loci (QTLs) for molecular phenotypes, such as gene expression, RNA splicing, and chromatin accessibility, provide rich data that can link variant effects in specific cell types with complex traits. These genetic effects can also now be modeled in vitro by differentiating human …
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A flow cytometry-based method for gene expression profiling of CNS cell types
… for profiling gene expression of specific cell types in the central nervous system (CNS), called fluorescence activated nuclei sorting (FANS). FANS utilizes flow cytometry to isolate cell nuclei from CNS subtypes and microarray analysis of nuclear mRNA. When compared to an existing …
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The effect of non-coding variants on gene transcription in human blood cell types
… dysregulation of gene expression. To understand cell regulation, first connections have to be found between elements contributing to gene expression and its regulation. During my PhD I have studied the regulatory effects of human genetic variation. To do so I have processed and analysed datasets …
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Molecular and Functional Characterization of Pyramidal Cell Types in the Frontal Cortex of Mouse Brain
… discrimination and memory consolidation. The cellular heterogeneity of the neocortex makes it difficult to understand the molecular and cellular substrate of cognition during normal brain function and disease related dysfunction. A deep understanding of the contribution of the neocortex to …
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ATP, trehalose, glucose, and ammonium ion levels in the two cell types of Dictyostelium discoideum
… was found to be present in stalk and/or spore cells. The accumulation of NH₄⁺ was interpreted as an indication of protein degradation, a source of energy in this organism. During the early stages of differentiation NH₄⁺ was localized only in stalk cells. However, it accumulated in spore cells …
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Transcending the Cell Fate Stereotype: Cell Penetrating Peptide Technology helps Induce Pluripotency in Multiple Cell Types
<p>Induced pluripotent stem cells (iPSCs) are one of the most promising new technologies in the field of regenerative medicine. iPSCs can be generated directly from a patient’s own fibroblast cells then converted into any cell type, thus overcoming challenges associated with embryonic stem cells …
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Marker-Free Isolation and Enrichment of Rare Cell Types Including Tumor Initiating Cells through Contactless Dielectrophoresis
… (µTAS) is the separation of circulating tumor cells (CTCs) from body fluids. Cancer cells spread from the initial site of a tumor by first invading the surrounding tissue, then by entering the blood or lymph vessels, and finally by crossing the vessel wall to exit the vasculature into distal …
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Development of high-throughput nanoparticle screening technologies to facilitate the delivery of genetic therapies to non-liver cell types
… if the genetic drug is delivered to the diseased cell type. One promising delivery method is through the use of Lipid Nanoparticles (LNPs), due to their ease of manufacture and favorable toxicity profiles. Yet, LNPs have only seen clinical success as delivery methods to liver cells. In order to …
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Conserved temporal ordering of promoter activation implicates common mechanisms governing the immediate early response across cell types and stimuli
… genes, have been identified in a range of cell types, under diverse extracellular signals and using varying experimental protocols. Genomic dissection on a case-by-case basis has not resulted in a comprehensive catalogue of IEGs. I completed a rigorous meta-analysis of eight genome-wide …
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Bead Based Peptidyl Libraries for the Selective Recognition of Glycoproteins, Differentiation of Carcinogenic Cell Types, and Determination of Enzyme Substrate Specificity
<p>The aberrant glycosylation of integral cell membrane and secreted glycoproteins is a hallmark of carcinogenesis and presents a unique opportunity to detect cancer at its earliest stages, when it is most treatable. Work towards developing boronic acid functionalized bead based peptidyl synthetic …
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To compare the expression, processing, incorporation and function of pseudoviruses and infectious molecular clones using different cell types and HIV backbones
… and processing affects function and whether cell type and/or expression system were responsible for these differences. Our data suggest that even though we did not observe differential expression of recombinant Env clones across cell types, when pseudovirus and infectious molecular clone …
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Defining The Role of Il-15 Trans-Presentation By Distinct Cell-Types During The Development and Homeostasis of Natural Killer and Invariant Natural Killer T Cells
… functions displayed by NK and iNKT cells have highlighted their importance as key lymphocytes involved in innate and adaptive immunity. Therefore, understanding the dynamics influencing the generation of NK and iNKT cells is extremely important. IL-15 has been shown to provide a …
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Understanding Intercellular Signaling During Lung Injury-Repair
… lung is a complex system of specialized cell types with precise spatial organization designed to cooperate to perform gas exchange. These cell types together coordinate organ development, homeostasis, and repair after injury through signals either presented or secreted, known as ligands, …
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Detection and characterization of rat hepatic stellate cells in a 3-dimensional, perfused, liver bioreactor
… homeostasis require the presence of all liver cell types. In vivo experiments offer only a snapshot of the liver, and usually involve perturbation of normal function through injury or experimental disease. The role of cell-cell interactions in maintaining normal liver function is far less …
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