Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 249 for “"Cell Type Specific"”.
-
Cell-type specific cholinergic modulation of the cortex
… In this thesis, I present evidence showing how specific neuronal and glial cell types can be differentially modulated by acetylcholine (Ach), resulting in dynamic functional interactions during ACh-modulated information processing and cortical plasticity. Chapter 2 identifies …
-
Cell Type-specific Analysis of Human Interactome and Transcriptome
Cells are the fundamental building block of complex tissues in higher-order organisms. These cells take different forms and shapes to perform a broad range of functions. What makes a cell uniquely eligible to perform a task, however, is not well-understood; neither is the defining characteristic …
-
Cell type-specific regulation of the chicken tyrosinase promoter
… coats of vertebrates, is synthesised by two main cell types: melanocytes and retinal pigment epithelial (RPE) cells. These two cell populations. which arise from distinct embryological origins, differ with respect to the rate at which they produce melanin and the ways in which they respond to …
-
Cell Type-Specific Contributions of FOXP1 to Human Cortical Development
Pages vi-xv are misnumbered as pages v-xiv, pages 89-129 are misnumbered as pages 87-127, and pages 130-174 are misnumbered as pages 124-168.
-
Cell-Type Specific Translational Profiling in Huntington's Disease Mouse Models
… neurons (MSNs) are among the most vulnerable cell populations in Huntington's Disease (HD). Within this population, striatopallidal MSNs are more vulnerable than striatonigral MSNs, which may explain the typical progression in HD of chorea to hypokinesis. The biological basis for this …
-
CELL TYPE-SPECIFIC EFFECTS OF OPIOID DEPENDENCE ON CENTRAL AMYGDALA NEURONS
… that the CeA comprises multiple functional cell-types. While decades of research implicate the CeA in opioid withdrawal, the cell type-identity of the affected CeA cells has received little attention. In this dissertation, I profile a major subtype of neurons in the central nucleus of the …
-
Cell Type-Specific Roles of FoxP Transcription Factors in Vocalization and Cognition
… with neurophysiological and behavioral phenotypes. Still, much remains unknown about molecular networks in the brain driven by these transcription factors, especially in specific regions and cell types. During my dissertation work, I sought to elucidate FoxP2 and FoxP1 functions in cortical, …
-
Cell-Type Specific Requirement for Pyruvate Dehydrogenase in Hematopoiesis and Leukemia Development
Pages i-xii are misnumbered as pages ii-xiii, and page 142 is misnumbered as page 121.
-
Cell-type specific CB1 receptor modulation of hippocampal synaptic plasticity and memory
… and learning mainly via the cannabinoid receptor type 1 (CB1)-dependent regulation of neuronal and glial activity. In the hippocampus, bidirectional communication between neurons and astrocytes shapes synaptic plasticity and behavior. CB1 receptors have been shown to be present in the astrocytes …
-
Cell-type-specific responses to DNA damage from acute and chronic radiation
… H2AX. Many experiments have been performed with cell lines derived from different origins and donors which, while invaluable for studying specific effects, restrict direct assessment of response variability between different cells, tissues and individuals. This thesis investigates normal tissue …
-
Viral and Cell Type Specific Host Factors that Contribute to Paramyxovirus Antiviral Responses
Activation of host cell responses during viral infection can be a critical factor in determining of viral tropism, dissemination, and pathogenesis. The paramyxovirus simian virus 5 (SV5) is able to establish highly productive, persistent infections of cultured epithelial cells with minimal …
-
HECAT5 regulates cell proliferation via interaction with M3R in cell type-specific manner
Embryonic stem (ES) cells are derived from pluripotent inner cell mass of the early mammalian embryo. Their self-renewal and pluripotency make them attractive sources for stem cell therapies. For ethical and practical reasons, ES cells have a major threat limiting in potential therapeutic …
-
Elucidating the structure-function relationship of the cell-type specific splicing regulator, RBPMS
… in differentiated vascular smooth muscle cells (VSMCs). RBPMS has an N-terminal RNA recognition motif (RRM) that mediates both RNA binding and dimerization, allowing binding to pairs of trinucleotide CAC motifs. The C-terminal tail is predicted to be unstructured, and such regions of other …
-
Deconvoluting Cell-Type Specific 3'UTR Isoform Expression in the Adult and Developing Cerebellum
… regulates these processes uniquely in specific cell types. Using a newly developed technique, termed conditionally-tagged poly(A) binding protein-mediated mRNA 3' end retrieval by crosslinking immunoprecipitation (cTag-PAPERCLIP), we discovered significant differences in alternative …
-
Investigating Cell-Type-Specific Vulnerability in Mitochondrial Disease Using Stem Cell-Derived Neuronal Models
… manifestations display remarkable tissue specificity, with certain cellular populations showing heightened susceptibility. Neurological involvement is among the most consistent features in these disorders, yet the molecular and metabolic drivers of selective vulnerability in different …
-
The role of cell type-specific tumour necrosis factor in protective immunity against neurotuberculosis
… contain mycobacteria by recruitment of immune cells that surround the bacteria. The cytokine tumour necrosis factor has been found to be involved in the recruitment of the immune cells and structure maintenance of granulomas. Tumour necrosis factor is a multifunctional proinflammatory cytokine …
-
Cell-type specific contributions to Rett Syndrome : neuronal and astrocytic signaling and sensory processing
… function is compounded by the heterogeneity of cell types in the brain, with recent evidence implicating glia cells in RTT pathophysiology. The focus of my thesis has been two-fold: exploring signaling mechanisms downstream of MeCP2 and the potential of IGF-1 as a therapeutic for RTT, and …
-
Investigation of Cell-Type-Specific Effects and Synergistic Interactions Between Genes in Duplication 15q Syndrome
… thought to be the primary cause of Dup15q phenotypes. However, animal models overexpressing UBE3A in neurons have not successfully recapitulated all aspects of Dup15q syndrome, especially epilepsy. Here, we used Drosophila melanogaster (fruit flies) to investigate Dup15q syndrome. In Chapter 2 …
-
Unraveling sorghum stem biology through organ-specific and cell-type-specific transcriptomic analyses across development
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
-
Transcriptional Heterogeneity in ALS: Patients with Retrovirus-mediated Disease and Potential Cell-type Specific Therapeutic Approaches
… biological pathways converging on a similar phenotype. To address this hypothesis, a bulk RNA sequencing (RNA-seq) dataset from almost 2,000 ALS and unaffected control samples was leveraged to uncover transcriptionally distinct patient subpopulations. Using non-negative matrix factorization (NMF), …
Page 1 of 13