Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Cell Transformation, Neoplastic"”.
-
Genetic and Molecular Studies of Endometrial Cancer
Endometrial cancer, which develops from the inner lining of the uterus, is the most common cancer of the female reproductive tract. Endometrial cancer is comprised of two epidemiologic, molecularly and genetically different subtypes known as type I and type II. Because of its clinical significance …
-
The Role of LKBI Tumor Suppressor in Endometrial Cancer
… LKB1 inactivation developed diffuse malignant transformation of their entire endometrium with rapid extrauterine spread and death, by 7 months, suggesting that LKB1 inactivation was sufficient to promote the development of invasive endometrial cancer. This much improved model also permitted the …
-
Regulation by ERK1/2 of Novel Substrates, Kinesins KIF2A and KIF2C
… function of KIF2A is utilized in mitotic cells as it is required to establish proper, bipolar spindles. Studies in KIF2A knockout mice revealed KIF2A function in regulation of interphase microtubules as KIF2A-/- neurons exhibit abnormal axon branching. Though protein kinases are known to …
-
Probing the Molecular Requirements for Breast Cancer Cell Motility
Invasion of breast cancer cells into the stroma is an early step in metastasis. How invasive ability is conferred in breast cancer cells is poorly understood. It has been shown that the tumor microenvironment can assist in the progression of cancer. The mechanism by which the microenvironment, …
-
The Role of Polyploidy in the Liver and Its Implications for Cancer Therapy
… Moreover, the additional alleles in polyploid cells led to a reduced likelihood of loss of heterozygosity (LOH), which largely contributed to the tumor suppressive effect. These results revealed an important function of polyploidy in mammalian livers and also led us to seek related therapeutic …
-
The Art of Viral Oncogenesis: Lessons from Human Papillomavirus and Polyomavirus Transformed Cancers
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.