Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Cell Transdifferentiation"”.
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The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis
… ligand-binding domain but expressing the intracellular domain. I show that absence of p75 neurotrophin receptor ligand-mediated signals leads to significantly retarded architectural resolution and reduced hepatic myofibroblast loss by apoptosis. Lack of the ligand-competent p75 neurotrophin …
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Targeting Endothelial Pathological Calcium Signaling Accelerates Resolution of SARS-CoV-2-Induced ARDS
… by accelerating alveolar type II to type I cell transdifferentiation, contributing to restoration of the alveolar-capillary barrier. Collectively, these findings identify EB3 as a critical upstream regulator of endothelial dysfunction in ARDS and establish its inhibition as a novel …
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Elucidating the regulatory mechanisms of pterygium
… treatment with transforming growth factor β on cell signalling and function of pterygial derived fibroblasts. Methods: Pure fibroblast cultures were established from cell outgrowths of pterygial tissue. Immunochemistry techniques were used to identify cell phenotype, tissue features and cell …
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Epithelial cell plasticity in chronic liver disease (MASLD/NAFLD)
… 2020). A potential mechanism of interest is the transdifferentiation of cholangiocytes into hepatocytes via either direct differentiation or via a progenitor cell population (Michalopoulos & Khan, 2015). However, the reality of this process in a disease context especially in human remains to be …
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Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming
… factors is sufficient to induce the transdifferentiation of lineage-restricted fibroblasts into functional neurons; however, a mechanistic model of the immediate-early events that catalyze this conversion has not been well defined. We utilized a high-efficiency reprogramming system of …
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Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores
Understanding genetic and cellular bases of adult form remains a fundamental goal at the intersection of developmental and evolutionary biology. The skin pigment cells of vertebrates, derived from embryonic neural crest, are a useful system for elucidating mechanisms of fate specification, pattern …