Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"Cell Stress"”.
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Smooth Muscle Cell Stress Response: Essential in Atherosclerotic Pathogenesis
… Recent research using lineage tracing and single-cell RNA sequencing unveiled a previously undescribed and prominent role of smooth muscle cells (SMCs) in atherosclerotic plaque formation. SMCs undergo complex phenotypic modulation characterized by de-differentiation of SMCs and heterogeneously …
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Chlorine dioxide impacts on microcystis aeruginosa cell stress, growth and microcystin production
… use of disinfectants was hypothesised to create cellular stress. Cellular stress was hypothesized to trigger increased production of cyanotoxins.;Here, chlorine dioxide (ClO2) was tested to inhibit a toxin-producing strain of Microcystis aeruginosa. Through a series of experiments, ClO2 was …
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Regulation of the Insulin-like Growth Factor 1-Secretory Clusterin Expression Axis in Genomic Instability and Cell Stress
… in human tumors and after exposure to cell stress. Understanding the regulation of sCLU expression in cancer, and after exposure to therapeutic agents, could reveal new therapeutic targets for cancer treatment. A DNA damage induced signaling cascade leading from ATM to sCLU expression …
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Mechanisms of HIV-Nef Induced Endothelial Cell Stress: Implications of HIV-Nef Protein Persistence in Aviremic HIV Patients
… protein, such as Nef in latently HIV-infected cells is a possible mechanism for vascular dysfunction underlying these diseases. HIVNef persists in two compartments in these patients: (i) extracellular vesicles (EV) of plasma and bronchoalveolar lavage (BAL) fluid and (ii) PBMC and BAL derived …
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Super Low Dose Endotoxin Exacerbates Low Grade Inflammation through Modulating Cell Stress and Decreasing Cellular Homeostatic Protein Expression
… may potentiate non-resolving innate immune cell inflammation through disrupting cellular endoplasmic reticulum (ER) homeostasis. We chose to study the dynamics of ER homeostasis in macrophages stimulated with SLD endotoxin. In naïve cells, ER stressor such as tunicamycin (TM) not only will …
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Biomarkers of cell stress and cell death detected by proton high resolution magic angle spinning (\(^1\)H HR-MAS) nuclear magnetic resonance (NMR) spectroscopy in a rat glioma cell line
… resonance (NMR) biomarkers of cytostasis and cell death in a rat glioma BT4C cell line. Cytostasis and cell death were induced in BT4C cells using cisplatin and substrate free medium, respectively. Cell viability was examined by various techniques. The lipid and metabolite alterations in whole …
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Heat shock protein 90, a potential biomarker for type I diabetes: mechanisms of release from pancreatic beta cells
… is a molecular chaperone that regulates diverse cellular processes by facilitating activities of various protein clients. Recent studies have shown serum levels of the alpha cytoplasmic HSP90 isoform are elevated in newly diagnosed type I diabetic patients, thus distinguishing this protein as a …
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Trabecular Calcium Phosphate Scaffolds for Bone Regeneration
… therapy bridges the traditional fields of cell biology, materials science and mechanical engineering with the aim to identify how cells behave on physiologically relevant materials with natural mechanical stimuli. The objectives of this research were to develop and characterize calcium …
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Cell-based sensors for quantifying cell health and disease progression in engineered systems
Healthy cells create healthy beings, while dysfunctional cells cause disease. Studying disease requires an understanding of how cells become dysfunctional from physiological states. Gaining this insight in vitro involves subjecting cells to relevant microenvironments and utilizing methodologies for …
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Androgen receptor-mediated growth suppression and apoptosis of human prostate epithelial cells
… and survival/death of luminal epithelial cells in the prostate gland and proliferation of malignant versions of these cells are not well understood, though they are central to prostate growth, homeostasis, and neoplasia. We hypothesized that in normal adult prostate, AR signaling may serve …
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Investigations into the role of RNA modification in the function of the c-Myc IRES
… patho-physiological conditions, which lead to cell stress, there is a rapid and large reduction in protein synthesis rates. This is mediated, in part, by a decrease in cap-dependent initiation. In several cases, it has been shown that cap independent pathways are used for the translation of …
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Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo
… heart were also divergent. Dex induced oxidative stress, cell stress pathways, caspase-3 mediated apoptosis, and p38 mediated reduced proliferation. Combined Beta treatment resulted in excessive GR activation (due to loss of negative feedback), activation of cell stress pathways, p53 mediated …
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Defining the ethanol-stress response in Saccharomyces cerevisiae
… yeast performance, acting as a potent chemical stress on yeast cells. This stress eventually inhibits yeast growth and reduces ceil viability, therefore limiting alcohol concentrations in the final product and increasing fermentation turnover times. The reduced cell growth rate and viability, as …
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P53 Drives A Transcriptional Program That Elicits A Non-Cell-Autonomous Response and Alters Cell State In Vivo
<p>Cell stress and DNA damage activate the tumor suppressor p53, triggering transcriptional activation of a myriad of target genes. The molecular, morphological, and physiological consequences of this activation remain poorly understood <em>in vivo</em>. We activated a p53 transcriptional program …
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Genetic and cytological investigation of Nucleostemin-1 in Drosophila melanogaster
… is a nucleolar GTP-binding protein implicated in cell cycle progression, stem cell proliferation, and ribosome assembly. Drosophila melanogaster contains a four-member nucleostemin family (NS1-4). Nucleostemin 1 (NS1) is the closest orthologue to human NS; it shares 33% identity and 67% similarity …
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Studies on Fortilin-Prohibitin Interaction
Abstract: Apoptosis, programmed cell death, is a tightly regulated process that occurs in development, in tissue maintenance and turnover, and in regulating the immune system. Alterations in apoptosis regulation is known to be involved in various diseases including cancer, autoimmune diseases, and …
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Building integrated cell-based microsystems : fabrication methodologies, metrology tools and impact on cellular physiology
… microsystems, and (3) the construction of live-cell stress reporters for the characterization of electric-field effects on cell physiology in microsystems. Materials for biological microsystems have been dominated by the elastomer polydimethylsiloxane (PDMS) and the photopolymer SU-8 which form …
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Autophagy During and Following Dynamic Exercise in Young Adults: Influence of Exercise Intensity
Autophagy plays a critical role in the cell’s response to exercise-induced cell stress. Exercise intensity and elevations in tissue temperature are known to modulate autophagic activation, however, the relationship is still unclear. Thus, we investigated the effect of increasing intensities of …
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Screens for non-eukaryotic initiation factor two alpha dependent activation of ATF4 translation
Cells must be able to respond to their environment. Inability to respond correctly to changes has direct consequences on cellular fitness. Eukaryotic cells have developed many different pathways to signal nutrient availability, cellular stress, and general environmental changes in order to maintain …
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Mechanisms of Impaired Efferocytosis of Synovial Macrophages in Knee Osteoarthritis
… the process for the clearance of dead and dying cells by macrophages, is impaired in OA patients. This project further explored the OA-specific mechanisms controlling efferocytosis in macrophages and investigated whether there was variation in different processes, gene expression, and pathways. …
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