Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Cell Stiffness"”.
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Studying the Role of Mechanical Properties of Cancer Cells in Tumour Detachment, Migration and Secondary Tumour Formation
Tumour cell detachment, migration and invasion, and secondary tumour formation are critical oncogenic processes during cancer metastasis. Although several molecular mechanisms have been reported to facilitate metastasis, it remains elusive how cellular mechanics contribute to these processes. The …
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Piezo1-dependent mechanical regulation of chemical signalling in the developing Xenopus laevis brain
… whereas mechanical signals include tissue stiffness, viscosity and cellular forces. In the developing embryo, chemical and mechanical signals are not isolated. However, how cells integrate these two different types of signals remains poorly understood. Here, I investigated how tissue …
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Cancer Cell Mechanics in Chemoresistance and Chemotherapeutic Drug Exposure
… is complex, recent studies have highlighted that cellular structure and extra-cellular composition, mechanics and structure play a role in the development of chemoresistance. The mechanical properties of cells impact their architecture, migration patterns, intracellular trafficking and many other …
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Biophysical and gene expression change in living cells by force-induced mechanotransduction
… in regulating the physiologic functions of cells and tissues. The importance of engineering principles in studying the biological behavior of cells is no longer in question. Instead, much research is now focused on how mechanical forces are transduced into biochemical activities and …
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Chemomechanics of attached and suspended cells
… coupling in single eukaryotic animal cells is investigated in the con- text of the attached (substratum-adhered) and the suspended (free-floating) states. These dichotomous configurations determine behavioral differences and commonalities relevant to therapeutic reimplantation of stem …
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Analysis of Linear and Nonlinear Quasiperiodic Metamaterials with Local Resonators
… to resonator parameters as well as the main cell stiffness. Multiple analytical and numerical methods of analysis are used. Eigenvalue analysis is used to obtain an analytical dispersion relation for each case, and the inverse method is used to characterize the formation mechanism for each …
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Effects of hypertension and aging on vascular smooth muscle cell contribution to reconstituted aortic tissue stiffness
Aortic stiffness increases with hypertension and aging, and much of this increase has been thought to occur due to changes in the extracellular matrix. However, an increase in cell stiffness could also be important. To study the cellular contribution to aortic stiffness, a reconstituted aortic …
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Mechanical Modelling of single and collective cells behavior
… direct implications of viscoelasticity of human cells and cell cytoskeleton dynamics on some relevant collective and at single-cell behaviors such as migration, adhesion, and morphogenesis. Other experimental studies have been performed on individual cancer and healthy cells of different types, …
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Study of T cell activation and migration at the single-cell and single-molecule level
T cells are required by their immunological roles to recirculate in the body and migrate to tissue sites, a journey that exposes them to distorting forces and physical obstacles that hinder their movement. Therefore, they must possess appropriate deformability to accommodate and adapt to these …
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Multiscale modeling and simulation of deformation and failure mechanisms of hierarchical alpha-helical protein materials
… key constituents of biological materials such as cells, hair, hoof and wool, where they assemble to form hierarchical structures. AHs play an important mechanical role in biological processes such as mechanotransduction, cell mechanics, tissue mechanics and remodeling. Whereas the mechanics of …
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Determining Mechanisms by which Pathological Extracellular Matrix induces Ocular Hypertensive Phenotypes in Human Trabecular Meshwork Cells
Purpose: Aberrant extracellular matrix (ECM) remodeling is prevalent in several sight-threatening diseases; in the trabecular meshwork (TM), it is implicated in elevated intraocular pressure (IOP), the only treatable risk factor for glaucoma. Herein, two different glaucoma-relevant cell-derived …
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Quantifying Structural and Functional Changes in Cardiac Cells in an In Vitro Model of Diabetic Cardiomyopathy
… and biochemical alterations at the cardiac cell level. Early stage cell alterations include hypertrophy, calcium mishandling, cell apoptosis, excessive ROS production, and increased collagen production by fibroblasts. Eventually, major structural and functional changes can appear in …
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Role of extracellular environment in mechanical properties of human cardiac fibroblasts and myofibroblasts
… loss. Cardiac fibroblast and myofibroblast cells are integral in the remodelling of injured tissue and are the most anticipated therapeutic target for cardiac fibrosis. To date, there is no anti-fibrotic therapy, which we argue, is due to the lack of knowledge on the functionality of the …
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Experimental and Computational Analysis of Cell Mechanics during Spreading and Migration
The processes of cell migration and spreading are critical for wound healing and cancer metastasis. Cells use their ability to generate mechanical forces to probe the mechanical resistance of their environment and move forward. Biomechanical explanations for how mechanical factors in their …
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Detection of mass, growth rate, and stiffness of single breast cancer cells using micromechanical sensors
… stems from a number of different mutations in a cell. These mutations often control the cellular growth and proliferation, a hallmark of cancer, and give rise to many altered biophysical properties. There exists a complex relationship between the behavior of a cell, its physical properties, and …