Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Cell Signals"”.
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Normal cell signals in human cancer transcriptomes
Cancer cells arise from normal cells, and may retain transcriptional patterns present in the cell of origin. Recent advances in single-cell transcriptomics have allowed us to profile both normal and cancer cells at a single cell resolution, enabling direct comparisons between the two. Such …
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Regulation and production of extracellular signaling molecules in Bacillus subtilis
Many bacteria use chemical signals for intercellular communication. These signals accumulate extracellularly and are sensed at threshold concentrations to alter gene expression. Bacillus subtilis uses cell-cell signals to control genetic competence, sporulation, degradative enzyme production and …
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Continuous Cardiorespiratory Monitoring Using Ballistocardiography From Load Cells Embedded in a Hospital Bed
… parameters using the ballistocardiogram (BCG) signals recorded with sensors embedded in a hospital bed. First, the heart rate (HR) estimation algorithms were presented. The first is signal processing-based HR estimation with array processing for multi-channel combination. The second uses a deep …
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Interaction of the DNA -Bound Estrogen Receptor With Coregulatory Proteins
… complexes reveal proteins involved in several cell processes including, transcription, DNA repair and replication, G-protein modulation, and scavengers of superoxide radicals. Investigation of the association of ERalpha with the DNA repair protein, 3-methyadenine DNA glycosylase (MPG) reveals …
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Performance Analysis and Modeling of Pavements with a Cold Central Plant Recycled Base under Accelerated Loading Testing
… was instrumented with strain gauges, pressure cells, and thermocouples. A heavy vehicle simulator (HVS) was used to load three replicate test sections in each lane, with the temperature controlled at 39°C at a depth of 1.5 inches. Results from the instrument verification analysis showed that …
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The Analysis of Two Receptor-like Kinases Redundantly Required for Pattern Formation during Arabidopsis Embryogenesis
The coordination of various cellular differentiation and morphogenetic programs during plant embryogenesis is required to establish the basic adult body plan. The molecular basis of these patterning events remains to be fully understood. In particular, little is known about the roles of cell-cell …
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
<p>The mesenchyme comprises of heterogeneous cell populations that support neighboring structures and are integral to intercellular signaling. Despite such importance, mesenchymal cells are poorly defined morphologically and molecularly. Their signaling regulation is not well understood, lagging …
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Clustering Single-Cell Electropherograms by Genotype Through Unsupervised Machine Learning
Cells can be linked to the person who produced them by examining the information contained within their DNA. The challenge that a forensic analyst faces is to question whether a collection of cells obtained from a crime scene supports the hypothesis that a person of interest was present. The …
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Neutrophils in advanced non-small cell lung cancer
… in the UK; 87% are histologically nonsmall cell lung cancer (NSCLC). At the time of diagnosis, patients frequently have advanced disease, with poor one-year survival due to metastatic burden. The immune system should act as a key line of defence; recognising, killing and clearing malignant …
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3D microfabrication of biological machines
… capable of high- resolution patterning of living cells and cell signals dispersed in an absorbent hydrogel polymer matrix in vitro. This novel enabling technology can be used to create model cellular systems that lead to a quantitative understanding of the way cells sense, process, and respond to …
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Characterising the gene regulatory landscape of CD4+ T cells
… with active regulatory elements in CD4+ T cells, and particularly in regulatory T cells (Tregs). CD4+ T cells are the orchestrators of the adaptive immune response and their dysfunction has been associated with immune-mediated disorders through uncontrolled activation and resistance to …
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Visualization of cellular signaling by fluorescence resonance energy transfer in response to biochemical and mechanical microenvironments
… have a great impact on a variety of cellular processes including cell adhesion and migration. While substantial progress has been made toward the understanding of how these factors regulate many cellular functions, it remains elusive on the molecular mechanism by which stem cells …
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Communicating with electrogenic cells
… and reliable communication with electrogenic cells is comprised of several techniques from dierent elds of research. Cellular signals need to be sensed and recorded utilizing extracellular recording devices with a temporal resolution that is higher than the duration of a single action …
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The role of cancer stem cells in osteosarcoma
… contain a small population of cancer stem cells (CSC) which initiate tumour growth. The cancer stem cell hypothesis describes cancers as a hierarchical population of heterogeneous cells. It has been proposed that CSC are at the base of this hierarchy and are responsible for the initiation, …
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THE CRITICAL ROLE OF CD4+ TH CELLS IN CD8+ CTL RESPONSES AND ANTI-TUMOR IMMUNITY
… was to elucidate the mechanism by which CD4+ T cells provide help for CD8+ cytotoxic T lymphocyte (CTL) responses in different immunization types. The establishment of diseases, such as chronic infections and cancers, is attributed to severe loss of or dysfunctions of CD4+ T cells. Even in acute …