Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Cell Physiological Processes"”.
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DECODING CELLULAR AND TEMPORAL VARIABILITY IN HUMAN CORTICAL DEVELOPMENT. INTEGRATING SINGLE-CELL TRANSCRIPTOMICS ACROSS DEVELOPMENTAL STAGES AND EXPERIMENTAL MODELS.
… and representation. Recent advances in single-cell profiling have provided a wealth of data on fetal and adult human cortex cells, but extracting insights from this information remains a significant hurdle. To address this challenge, we present NeuRoDev, an innovative analytical and data …
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Scaffold-Mediated Organization of Signal Transduction Networks
… conserved signal transduction module involved in cellular processes ranging from proliferation and differentiation to transformation and apoptosis, and is engaged in response to growth factors, cytokines, morphogens, and other extracellular stimuli. Given the ubiquitous nature of this signaling …
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Mechanism and Regulation of ERK2 Subcellular Localization
… events in signaling networks that control cell behavior. ERK1/2 activation contributes to regulated processes such as proliferation, differentiation and survival through the phosphorylation of multiple nuclear and cytoplasmic substrates. The pleiotropic effects of ERK1/2 activation suggest …
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Uncovering the Complexity of RAS Signaling Networks
… a key Ras effector pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic transformation. Here we describe two important aspects to understanding the signaling complexity of any multiphenotypic arrangement, namely, the …
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Substrate Interaction and Sub-Cellular Localization in Map Kinase Pathways
Protein kinase cascades control responses to extracellular cues by transmitting signals throughout the cell. Prominent among multifunctional enzymes in kinase cascades are the mitogen-activated protein kinases (MAPKs). Among the various MAPKs identified, the extracellular signal-regulated kinases, …
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Identification of Intracellular Signaling Pathways Regulated by the TAO Family of Mammalian STE20p Kinases
… MEK3 and 6. Little is known about the precise cellular roles for these TAO protein kinases, or whether they function together or individually within the cell. Recently, genome-wide screens have identified these protein kinases as important mediators of vital cellular processes such as …