Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 103 for “"Cell Phenotype"”.
-
Characterizing B Cell Phenotype During Chronic HCV Infection
… by an attenuation of virus-specific T cell responses. The mechanisms leading to T cell attenuation are still not well understood, and likely involve several integrating correlates. We hypothesized that dysfunctions of antigen presenting cells (APC) may contribute to the immunosuppresed …
-
scPhen: Single-Cell Phenotype Predictor for Alzheimer’s Disease
… to model complex biological systems. Single-cell RNA sequencing (scRNA-seq) provides unprecedented resolution into cellular heterogeneity, offering a powerful substrate for modeling disease circuitry. However, predicting patient-level phenotypes from scRNA-seq remains challenging due to …
-
A Computer-Aided Framework for Cell Phenotype Identification, Analysis and Classification
… to tackle this disease is to first study it at a cellular level. This study aims at identifying various phenotypic traits of these cells in the Dielectrophoresis (DEP) based microfluidic device experimental setup and subsequently classifying the cells from the rest. A general framework for …
-
Cell Phenotype Analyzer: Automated Techniques for Cell Phenotyping using Contactless Dielectrophoresis
… cannot be cured. However, if the precise cancer cell type is diagnosed at an earlier, less aggressive stage then the chance of curing the disease increases with accurate drug delivery. This work is a humble contribution to the advancement of cancer research. This work delves into biological cell …
-
Engineering Myeloid Cell Phenotype Using Cell Surface-Adhered Microparticles for Therapeutic Applications
Cell-based therapies present a new frontier for treating previously untreatable diseases. Living cells can innately overcome biological barriers, respond in real-time to biological stimuli, interact with specific cell types, and provide a canvas for further cellular engineering. The crucial role of …
-
Biomaterials for tissue engineering for rheumatoid arthritis based on controlling dendritic cell phenotype
… was to understand the response of dendritic cells (DCs) to different biomaterials upon contact and identify biomaterials suitable for use in tissue engineering constructs for rheumatoid arthritis (RA) applications. Differential levels of functional DC maturation were observed depending on the …
-
Substratum Interactions Modulate the Interplay between Endothelial Cell Phenotype, Function, and Immune Recognition
Endothelial cells (ECs) sense and adapt to their environment, allowing them to shift between a range of functional phenotypes. When connected in a monolayer they create the endothelium, a barrier and a platform from which ECs can individually respond to flow, and circulating cells and factors …
-
Effects of The Acta2 R258C Mutation On Vascular Smooth Muscle Cell Phenotype and Properties
… to injury. We characterized smooth muscle cells (SMCs) from bothmouse models under the hypothesis that mutant α-actin has a dominant negative effect, leading to impaired contractile filament formation/stability, improper focal adhesion maturation and increased proliferation.</p> …
-
Memory Potential, Molecular Characterization, and Translational Applications of The Novel Theo/Tceo T Cell Phenotype
<p>T cells comprise a substantial arm of the immune system and are exquisitely adapted to combat pathogens and tumors. The inflammatory environment largely dictates the nature of T cell response. A hallmark of T cell-mediated immunity is formation of immunological memory; the ability to respond …
-
Investigating the Interplay between Inflammation and Matrix Stiffness: Evaluation of Cell Phenotype and Cytoplasmic Stiffness In Vitro
The cellular microenvironment in vivo consists of both mechanical and chemical signals, which drive cell function and fate. These signals include the composition, architecture, and mechanical properties of the extracellular matrix (ECM), signaling molecules secreted by cells into their …
-
TL1A Priming Induces a Multi-Cytokine Th9 Cell Phenotype That Promotes Robust Allergic Inflammation in Murine Models of Asthma
… TL1A increases IL-9 production from Th9 cells. However, its role in regulating other functions of Th9 cells is unknown. Here we demonstrate that TL1A increases expression of IL-9 and IL-13 as well as the frequency of IL-9 and IL-13 co-expressing cells in murine Th9 cell cultures, inducing …
-
Effect of bovine lactoferrin on T lymphocyte cell phenotype and function and the response to vaccination in the neonatal piglet
… of bLf would enhance vaccination response and T-cell function in formula-fed piglets. To address this hypothesis, two specific aims were undertaken. N Specific Aim 1 investigated the effect of bLf supplemented to infant formula on the response to immunization against influenza virus and serum Ig …
-
Angiogenic growth factors and notch signaling regulate liver sinusoidal endothelial cell phenotype in combination with matrix stiffness and ECM composition
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
-
Cadherin-Mediated Cell-Cell Interactions Regulates Phenotype And Morphology of Nucleus Pulposus Cells Of The Intervertebral Disc
<p>Juvenile nucleus pulposus (NP) cells of the intervertebral disc (IVD) are large, vacuolated cells that form cell clusters with numerous cell-cell interactions. With maturation and aging, NP cells lose their ability to form these cell clusters, with associated changes in NP cell phenotype, …
-
The Influence of Normal Physiological Forces on Porcine Aortic Heart Valves in a Sterile Ex Vivo Pulsatile Organ Culture System
… environment which leads to force dependent cellular and tissue responses. Characterization of these responses provides a fundamental understanding of valve pathogenesis. The aim of this work was to develop an ex vivo organ culture system capable of simulating physiological aortic pressures …
-
Coordinated regulation of the snail family of transcription factors by the notch and tgf-0 pathways during heart development
… EndMT is the process by which endocardial cells of the atrioventricular canal and the outflow tract repress endothelial cell phenotype and upregulate mesenchymal cell phenotype. EndMT is initiated by inductive signals emanating from the overlying myocardium and inter-endothelial signals and …
-
Peptide microarrays for the discovery of cell-ligand interactions that direct cell state
During development, cells receive many cues from their environment. These cues, whether physical or chemical in nature, are able to regulate the behavior of cells from macroscale levels such as tissue organization, to microscale levels such as gene modifications. Synthetic materials are able to …
-
The Role of Metabolism and Epigenetics in Regulating Cellular Plasticity
Eukaryotic cells encode genetic information in the form of DNA. However within our genetic code, only a subset of these genes are expressed in a given cell—giving rise to different cell types. The regulation of what genes are expressed is dictated by epigenetics. Epigenetics is the punctuation of …
Page 1 of 6