Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Cell Permeable Peptides"”.
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Disrupting the inhibitory Kappa B kinase (IKK) - Aurora A axis in cancer
… This regulates NF-κB signalling and related cellular inflammatory responses that are often constitutively active in many cancer cells. Beyond regulation of NF-kB signalling a number of other potential IKK substrates have been proposed including the mitotic kinase Aurora A, one of three …
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An investigation into the role of Bcl-3 in toll-like receptor signalling
… this thesis the role of the IκB protein Bcl (B-cell lymphoma)-3 in the regulation of TLR signalling is investigated. Bcl3-/- mice and cells are hyper responsive to TLR stimulation and are defective in LPS tolerance. Bcl-3 interacts with and blocks the ubiquitination of homodimers of the NF-κB …
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CYCLIZATION-BASED SITE-SELECTIVE N-TERMINAL CYSTEINE CONJUGATION, PEPTIDE STAPLING AND HISTONE DEACETYLASE (HDAC) PROBING
… modify N-terminal cysteines of unprotected peptides or proteins in a single step. We showed that α-fluoroketone molecules afford the cyclization reaction with the beta amino thiol group of N-terminal cysteine. Both chemo and stereo-selectivity of this reaction have been studied using 2D NMR …
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Bioengineering of a TAT-conjugated Peptide to Modulate the Activity of Glycogen Synthase Kinase-3 in Adult and Embryonic Stem Cells
The intracellular delivery of molecules to modulate signaling pathways and gene expression is a powerful approach to control stem cell fate decision. For applications in gene therapy and regenerative medicine, the use of genetic material and viral vectors raise concerns because stem cells persist …
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Targeting RNA Structures with Multivalent Branched Peptide Libraries
… Furthermore, these compounds were shown to be cell permeable and displayed little to no cytotoxicity in HeLa and A2780 cells.