Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Cell Orientation"”.
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Modelling Cell Orientation In Artificial Tissues
… between physical forces and the arrangement of cells in engineered tissue. In this thesis, emphasis is put on the interaction between astrocytes within engineered neural tissue (ENT). The main aim of this work is to create a computational model which will be able to predict the arrangement of …
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Fabrication and evaluation of a collagen-based fiber-gel three-dimensional construct for peripheral nerve repair
… mediated guidance and the presence of Schwann cells to support the regenerating axons and remyelinate portions of denervated nerve pathways. The emphasis of this work is to develop a synthetic nervous tissue construct that contains similar basal lamina or extracellular matrix to peripheral …
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Fabrication of topographically patterned hydrogel substrates and their influence on cell morphology
Cell behavior is influenced by a multitude of extracellular factors including chemistry, mechanics, and geometry. Engineered microenvironments can be used to assess a wide range of such influences on cell behavior and identify parameters for future implementation into tissue engineered scaffolds. …
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Genomic Approaches for Pathway Identification in Regenerating Sensory Epithelia of the Inner Ear
The inner ear utilizes sensory hair cells as mechano-electric transducers for sensing sound and balance. In mammals, these sensory hair cells lack the capacity for regeneration and if damaged lead to hearing or balance disorders. However, non-mammalian vertebrates such as birds maintain their …
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Thin film amorphous silicon cells by inductive PECVD, with a view towards flexible substrates
… range of amorphous silicon based films and solar cells have been fabricated using an inductively coupled PECVD reactor in order to investigate how the deposition conditions influenced their properties. Complete cells were deposited onto rigid and flexible substrates, and homogeneous thin films …
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Modulation of mesenchymal stem cell invasion into decellularized engineered tissues
… the organization and alignment of the extracellular matrix (ECM) in developing and mature tissues, where the organization gives the tissue its unique functional properties. This dissertation will discuss research that is fundamental to the understanding of the interaction of cells with the …
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Athlete and Coach Knowledge, Attitudes, and Perceptions of Sickle Cell Trait and National Collegiate Athletic Association Mandated Testing: Recommendations for Intervention
<p>Individuals with Sickle Cell Trait have died suddenly after extreme exertion during military training, athletic practice or games (Kerle & Nishimura, 1996; Harrelson, Fincher & Robinson, 1995; Howe & Bowden, 2007). One of those deaths, Dale Lloyd, a football player at Rice University, prompted a …
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A Discrete Monolayer Cardiac Tissue Model for Tissue Preparation Specific Modeling
… do not account for the effects of random cell shapes, cell orientations and cleft spaces inherent in these monolayers on the resulting wavefront conduction. Additionally when the continuous computer model is built to study impulse propagations, the intracellular conductivities of the model …
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Quantification of Dynamic Epithelial Sheet Architecture in Botryllus Schlosseri Using 2-D & 3-D Image Analysis
… morphology. In normal vessels, we found the cells to be planar polarized with curvature - dependent axial elongation of cells, and a robust circumferential alignment of actin bundles. While we found no measurable differences in morphology between normal and BAPN treated vessels, FAK-inhibited …
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Mechanisms of reorientation in phytoplankton : fluid shear, surface interactions, and gravitaxis
… and interaction with surfaces of these important cells. Using accurately controlled shear flows in microfluidic devices, we show that the interaction of flow and motility can produce strong spatial heterogeneity in the distribution of phytoplankton. Four different species were tested over a broad …
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Strain-phase relations in lead-free ferroelectric KxNa1-xNbO3 epitaxial films for domain engineering
… theoretical considerations with regard to film orientation and phase symmetry are essential. To predict the energetically most favorable film unit cell orientation on a substrates, linear elasticity theory was used in this thesis. For engineering the domain structure, a misfit strain-misfit …
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Mathematical modelling of growth, reorganisation and active response in cells and tissues
The understanding of biological systems like cells and tissues is increasingly taking advantage of tools from quantitative sciences, which can provide powerful instruments to unravel complex mechanisms. In this respect, the emerging field of mechanobiology, that aims at analysing how mechanics …
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Structured polymer thin films: self-assembly and forced-assembly
… solution-casting method which induced the orientation of GO fillers, resulting in remarkable gas barrier and separation properties at GO concentrations around 5 wt% and higher. This thesis explores the effect of GO sheet size; larger GO sheets (LGO) were synthesized using the modified …
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Additive Manufacturing of Functional Materials for Biomedical Devices
… and biomedical surfaces for the regulation of cell growth. Anisotropic, self-assembling, and self-reinforcement hierarchical liquid crystal polymer (LCP) are 3D printed with the form of fibres into macroscopic non-linear strain-hardening metamaterials to fabricate lightweight and flexible ankle …