Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 102 for “"Cell Nucleus"”.
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Ribose nucleic acid and the cell nucleus
… for the estimation of that substance in isolated cell nuclei described.
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Phosphoproteins of the Cell Nucleus: Metabolism and Characterization
… proteins which are found localized in cell nuclei. The studies focus first on phosphoprotein metabolism as it occurs in the intact nucleus under varying conditions, and then on the chemistry and enzymology of a phosphoprotein fraction which has been extracted and purified from isolated …
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Dynamic organization of chromosomes in the mammalian cell nucleus
… increasing interest in the past decade. The nucleus of higher eukaryotes is considered to display a highly dynamic interaction of DNA and protein factors. There is an emerging view that there are hierarchical levels of gene regulation, reaching from epigenetic modifications at the DNA- and …
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Representing science in the UK news media: ‘Life on Mars?’, cell nucleus replacement and Gulf War syndrome
… on Mars. The second case study tracks the use of cell nucleus replacement to “clone” mammals. The third case study examines the scientific and political controversy over the existence, symptoms, causes and response to “Gulf War syndrome”. The empirical research employed methodologies developed at …
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Analysis of 3D Genome Organization in 4-Cell Mouse Embryos
Cell fate determination, which refers to how distinct types of signals interact with a cell to determine its fate and differentiation into a particular cell type, is a fundamental questions lying at the heart of developmental biology. Given that the type and state of a cell is deter-mined by its …
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Analyse der Chromosomenverteilung in menschlichen Fibroblasten mittels 3D-Vielfarben Fluoreszenz in situ Hybridisierung
In human diploid fibroblasts (HDFs) the cell nucleus is oval in shape, quite large in xy-diameter (10-20µm), but flat in z-direction (5µm). In these nuclei chromosome territories typically lie side by side or slightly above each other. The question whether these arrangements are ordered or variable …
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Engineered hydrogels for tracking cell signaling from the outside-in
… therapies involves the conversion of somatic cells back into an embryonic stem cell (ES)-like state, termed induced pluripotent stem cells (iPS). iPS cells have the same potential for differentiation as ES cells and hold immense promise for tissue engineering, regenerative medicine, and …
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Irradiators for measuring the biological effects of low dose-rate ionizing radiation fields
… single instances of energy deposition within a cell or from the combination of separate instances, but at low dose-rates biological repair mechanisms reduce the probability of effects resulting from the combination of separate instances. At a sufficiently low dose-rate the effects due to …
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Viscoelastic two-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations
Introduction: Cells are exposed to a wide variety of forces within the human body, and the mechanisms by which cells respond to these forces are largely unknown. From altering gene transcription in the cell nucleus to conformational changes in membrane channel proteins that lead to increased or …
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A DNA Determination in Developing Chick Marginal Tissue
… of deoxyribonucleic acid (DMA) located in the cell nucleus. These inheritance factors were also ascribed to the cytoplasm by the German botanist, Carl Correns (1904). Within the past few years evidence has been presented that these inheritance factors, or, cytoplasmic DNA, can be found in a …
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"""TSA-Seq"": a novel proximity mapping approach for studying three dimensional genome organization and function"
… chromatin and its localization in the eukaryotic cell nucleus plays a critical role in gene regulation (Agarwal and Rao, 1998; Brown, 2003; Ferrai et al., 2010) and is important for maintaining normal genome function. However, although it is known that the distribution of chromatin and genes in …
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Theory and application of neural and graphical models in early cancer diagnostics
… ISIC-ISBI Melanoma Classification Challenge, and cell nucleus data.
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Molecular mechanisms of thyroid hormone transport: the role of amino acid transporters
… is controlled by receptors present in the cell nucleus,<br/>therefore extracellular TH must first cross the plasma membrane to gain entry<br/>into the cell. The exact mechanisms of TH transport across the plasma<br/>membrane are only beginning to be clarified, but it is likely that …
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Novel Single Cell Methods to Identify the Genetic Composition at a Single Nuclear Structure
… DNA obtained from a nanoscale region of a single cell nucleus based on either direct DNA dissection with high-precision nano-tools operated inside a scanning electron microscope, or the ligation of oligo probes to subnuclear sites of double stranded breaks induced by 2-photon irradiation. It is …
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Mechanism of Nuclear Protein Import and Export an In Vitro Approach
<p>Protein import and export into and out of the cell nucleus requires a signal in the protein to be transported. Furthermore, several factors are involved in recognition of the signal, delivery of the protein to the nuclear pore complex (NPC) and its subsequent translocation across the NPC. We …
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Analysis of Interphase Chromatin Motion in HeLa Cells
… interphase chromatin mobility in the cell nucleus. Interphase chromatin undergo replication prior to cell division with the assistance of replication proteins (machinery) which modify chromatin mobility. Using dual color imaging of flourescently tagged chromatin and proliferating cell …
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Investigating the role of molecular motors on chromatin organization
… and information is densely packed within the cell nucleus. To facilitate the proper functioning of numerous life-essential biological processes, it possesses multiple levels of packaging. On one hand, nucleosomes, as the most fundamental packing unit, controls the accessibility of chromatin …
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Fast Monte Carlo Cell-By-Cell Simulation of Radiation-Induced DNA Damage, Chromosome Aberrations, and Cell Death for Low-Dose-Rate Brachytherapy Sources
… chromosome aberrations has enabled studies of cell survival characteristics to be performed via computer simulation. TOPAS, a Monte Carlo based physics modeling tool, contains models of the brachytherapy sources commonly used in radiation therapy for the treatment of cancer patients. …
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Gold nanoparticle cellular uptake and its implications for cancer therapy
… uptake of gold nanoparticles (AuNPs) in cancer cells. <br/><br/>In the first study a technique is developed to probe the temporal dynamics of AuNP uptake by performing multiphoton fluorescence-lifetime imaging microscopy (MP-FLIM) on live cells. Using this technique and subsequent analysis …
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Approaching the Three-Dimensional Organization of the Human Genome
… and three-dimensional organization of the human cell nucleus, the structural-, scaling- and dynamic properties of interphase chromosomes and cell nuclei were simulated on the 30 nm chromatin fiber level with Monte Carlo, Brownian Dynamics and parallel computing methods. Differences between used …
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