Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"Cell Movement"”.
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Investigations of collective cell movement during gastrulation in the chick embryo
… the mesendoderm trajectories. However, the cellular responses were assessed in vivo and due to the complexity of the environment, they could not be fully interpreted. This is because the introduced ligands might have triggered the secretion of secondary factors to which the cells responded. …
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Nonlinear Nonlocal Parabolic-Hyperbolic Coupled Systems for Cancer Cell Movement and Aggregation
Cells adhere to each other and to the extracellular matrix (ECM) through protein molecules on the surface of the cells. The breaking and forming of adhesive bonds, a process critical in cancer invasion and metastasis, can be influenced by the mutation of cancer cells. Several molecules have been …
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Investigation of cell movement and the associated cytoskeleton during chick gastrulation and somitogenesis
Cell migration involves dynamic and spatially regulated changes to the cytoskeleton. During avian gastrulation, cells ingress through the primitive streak. Previous characterisation of microtubule organisation during this process revealed the distribution of cells with polarised and radial arrays …
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Determination of the molecular mechanism of cell-to-cell movement in squash leaf curl geminivirus
The intercellular spread of plant viruses is an essential process with extensive implications for the life cycle of the virus, and the cell biology of the host. In all plant viruses, intercellular spread is accomplished by a special class of viral encoded protein, termed movement proteins (MPs). …
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Adhesion receptor-cytoskeleton interactions in migrating tissue cells
Cell migration is a phenomenon requiring dynamic adhesive interactions between the internal cell motile machinery and the external substratum, with adhesion receptors, such as integrins, serving as the transmembrane link. The goal of this dissertation was to investigate the mechanism by which …
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Adaptive Spline Method for the Assessment of Cell Motility and its Application to Lesions
… to contain. Measures to stimulate or inhibit movement of cancer cells may play an important part in metastasis biology. The movement behaviour of individual cells within a cluster may give new clues about cell-to-cell interactions. However, the recognition and tracking of individual cells in …
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Phototaxis of Dictyostelium discoideum Slugs
During the slug stage of cellular slime mold Dictyostelium discoideum, up to 105 cells coordinate their movement and migrate as a single organism. Slugs have a cylindrical shape with tip and tail; their morphological polarity corresponds to the polarity of migration. A large body of results suggest …
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Distinct Functions and Regulation of Nonmuscle Myosin II Isoforms a and B in Cell Motility
<p>The ability of cells to migrate is of fundamental importance to a diverse array of biological processes, both physiological and pathological, such as development, the immune response and cancer cell metastasis, to name a few. The process of cell movement is a complicated cycle of coordinated …
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Transcriptome-wide organization of subcellular microenvironments revealed by ATLAS-Seq
Subcellular localization of RNAs is a ubiquitous and evolutionarily conserved process that provides an additional layer of transcriptome organization promoting coordinated control of gene expression in both space and time. It has been shown to contribute to processes ranging from cell fate …
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Effects of cross-link and myosin motor concentrations on active muscle gel contraction time and extent
… network of actin filaments that gives the cell its shape, assists in organelle organization, and allows for cell movement. Active muscle gels are a class of materials that that mimic the functionality of the cytoskeleton. Utilizing myosin II motor proteins to initiate contraction events in …
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Quantitative Proteomic Methodology Use and Development to Characterize Ethanol Modulation of Microglial Function
… quantify the microglial proteome in immortalized cell lines and in vivo enriched microglia. Our proteomic profiling and subsequent validation suggests that microglia do activate in response to ethanol exposure, but the activation falls short of the classical, or M1 state of inflammatory …
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Automated cell-targeted electrophysiology in vivo and non-invasive gamma frequency entrainment
… method for characterizing visually identified cells in intact neural circuits, but it requires skill to perform. We found that a closed-loop real-time imaging strategy, which continuously compensates for cell movement while approaching the cell with a pipette tip, allows for the development of …
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Role of gamma-aminobutyric acid (GABA) in hypothalamic nuclear development
… sex behavior, and aggression. It is divided into cell groups based on cell staining, functional similarities and projections. This dissertation looks at the development of three of these cell groups, the ventromedial nucleus (VMN), the paraventricular nucleus (PVN), and the arcuate nucleus (ARC). …
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A Two-Component Model For Bacterial Chemotaxis
Chemotaxis is the directed cell movement in response to chemical signals. It iscrucial in many multicellular processes, such as wound healing, cancer metastasis,embryonic development and bioremediation. Quantitative descriptions of chemotaxiswill lead to a better understanding of the mechanisms of …
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Biomimetic cytoskeleton assemblies and living cells on micropillar force sensor arrays
… arrays are produced for biophysical studies of cellular and intracellular mechanics and for the assembly of suspended biofilament networks. Three types of pillars are made: (1) gold capped silicon pillars, (2) epoxy pillars and (3) polydimethylsiloxane (PDMS) pillars. Pillars with diameters of 1 …
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The application of signaling networks to cancer metastasis and cellular motility through the EGFR pathway
… descriptions of the mechanical machinery of the cell to characterize the foundations of cell movement in response to stimuli. By quantifying and qualifying the signaling networks and molecular pathways involved in cellular signaling and linking intracellular signaling to the mechanical machinery …
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Mechanically-induced intercellular remodeling of cardiomyocytes by magnetic micromanipulation
… for providing and maintaining a pathway for intercellular communication. This is critical in the heart where gap junctions are responsible for maintaining electrical impulse propagation. Connexin43 (Cx43) is the most abundant gap junction in the heart, and studies have shown that spatial …
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Design and use of an environmental control platform for studying vascular cell function in three-dimensional scaffolds
Endothelial and smooth muscle cells are the core of the vascular system. Vessels are created and repaired through the processes of angiogenesis and arteriogenesis. Endothelial cells are the initial cells that migrate and proliferate during the process, followed by smooth muscle cell movement and …
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Microfabrication methods for the study of chemotaxis
… while providing a viable environment for the cell. Numerical models were generated to investigate fluid flow in microchannels for given geometries. Through computational modeling and experimentally-driven iteration of the design, features of the chamber were determined and geometry was …
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A Phenotypic And Genetic Characterization Of The Cell Adhesion Molecules Echinoid And Friend-Of-Echinoid In The Directed Cell Movements Of Ommatidial Rotation During Drosophila Eye Development.
Correct development of multicellular organisms relies on the precise patterning of cells, which must respond to and interpret specific cues that instruct the cells to differentiate and often undergo directed cell movements and rearrangements to give rise to functional tissues and organs. …
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