Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 182 for “"Cell Motility"”.
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cell motility and machine learning
Cell migration is a necessary function in organisms. It is relevant to wound healing, immune reaction, cancer expansion. One example is durotaxis: Cells exhibit qualitatively different behaviors on substrates with different rigidities. The fact that cells are more polarized on the stiffer substrate …
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Physical minimal models of amoeboid cell motility
Cell locomotion plays an important role in many biological processes such as the immune system, embryonic development, or cancer metastasis. In these examples, cells interact with their environments or coordinate their movements with other cells, creating collective behavior. In this thesis, we …
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Molecular Mechanism of Tetraspanin CD9 Mediated Cell Motility
… of proteins participates in the regulation of cell adhesive functions such as cell migration. The mechanisms underlying CD9 mediated cell migration are not known. In the current study, we investigated the molecular basis for the CD9 promoted cell migration. Our findings show that the …
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Synthetic Peptide Ligand Mimetics and Tumor Cell Motility
Human tumor cell progression and metastasis is partially dependent on the ability of tumor cells to adhere to the proteins of the extracellular matrix and migrate to distant locations. Using a combinatorial screening approach, six novel D-amino acid containing peptides were identified and analyzed …
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Structure, function, and dynamics of cell motility proteins
… structure and function relationships in cell motility proteins at atomic resolution. (1) To analyze motions in cell motility proteins an algorithm is described to identify and visualize the movements of rigid domains about common hinges in proteins. In comparing two structures, the method …
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P53 mediated cell motility in H1299 lung cancer cells
… NFκB promote invasion and metastasis in tumor cells. Signals transduced by AKT and p53 are integrated via negative feedback between the two pathways. Tumor derived p53 was also indicated to induce NFκB gene expression. Due to the close relationship between p53/AKT and p53/NFκB, we hypothesized …
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Probing the Molecular Requirements for Breast Cancer Cell Motility
Invasion of breast cancer cells into the stroma is an early step in metastasis. How invasive ability is conferred in breast cancer cells is poorly understood. It has been shown that the tumor microenvironment can assist in the progression of cancer. The mechanism by which the microenvironment, …
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Regulation of cell motility by Shp-2 tyrosine phosphatase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The Effects of RHAMM on Cell Division, Cell Motility, and Tumorigenesis
… are predicted to regulate genomic stability and cell polarity and proposed to account for the oncogenic function of RHAMMΔ163. We hypothesized that RHAMM leucine zipper maintains mitotic spindle integrity and impacts directional cell migration through its interactions with microtubule and …
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A role for myosin in the regulation of mammalian nonmuscle cell motility.
… myosin in the regulation of mammalian nonmuscle cell motility.
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STUDIES OF CELL MOTILITY AND DIFFERENTIATION IN COMPLEX 3D IN VITRO MICROENVIRONMENT
<p>Cell behaviors, such as motility and differentiation, which are highly regulated by the complex 3D in vivo microenvironment, have been extensively studied in the past decades to better understand the mechanisms of development, disease, and healing. Due to the highly complex nature of the in vivo …
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Engineering semiconductor quantum dots for quantitative imaging of cell motility and invasion
… quantify non-specific binding to different extracellular matrix (ECM) proteins. QDs coated with poly-maleic anhydride (PMA), which had been modified to present alkane, alkene, alkyne, PEG and carboxylic acid, carboxylic acid, and solely PEG, were incubated on poly-l-lysine, collagen, fibronectin, …
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Synthesis of small-molecule HGF-Met inhibitors for use in preventing cell motility
… they have in aiding wound healing and preventing cell motility through competitive inhibition of the HGF-Met pathway. This pathway is extremely important in various cellular processes including cancer development, metastasis, tissue regeneration, damage and cell motility. This project aimed to …
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Adaptive Spline Method for the Assessment of Cell Motility and its Application to Lesions
… to stimulate or inhibit movement of cancer cells may play an important part in metastasis biology. The movement behaviour of individual cells within a cluster may give new clues about cell-to-cell interactions. However, the recognition and tracking of individual cells in clusters is …
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A NOVEL BRAF SIGNALING CASCADE THROUGH p-21 ACTIVATED KINASES REGULATES THYROID CANCER CELL MOTILITY
… to the nucleus via serine-threonine kinases. Cell processes that are regulated through this pathway include growth, differentiation, development, inflammation and apoptosis. In thyroid cancer, gene rearrangements and point mutations in MAPK signaling molecules are a common event. These …
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Distinct Functions and Regulation of Nonmuscle Myosin II Isoforms a and B in Cell Motility
<p>The ability of cells to migrate is of fundamental importance to a diverse array of biological processes, both physiological and pathological, such as development, the immune response and cancer cell metastasis, to name a few. The process of cell movement is a complicated cycle of coordinated …
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Genomic Conservation of the Outer Hair Cell Motility Protein, Prestin in the Monotreme: Ornithorhyncus anatinus (Platypus)
The process of outer hair cell (OHC) motility, which enables sound amplification, is an active process that is thought to be unique to mammals. Prestin, the motor protein of these OHCs, is crucial for its function in mammals. Loss of prestin has been found to result in a high-frequency hearing loss …
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The Development of a Printable Device with Gravity-Driven Flow for Live Imaging Glioma Stem Cell Motility
… GBM treatment in the form of therapy resistant cell subsets and influence on cellular phenotypes. One cell subset in particular, glioma stem cells (GSCs), is frequently left behind in the brain parenchyma once the bulk of the tumor has been resected. Previous research has found that …
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Biophysical regulation of cell motility by adhesion ligands and growth factors : effect of spatial presentation of the ligand
… is in understanding the mechanisms which control cellular functions such as cell proliferation, migration and differentiation. The ability to engineer tissue replacements requires understanding of the interactions between the cell and its environment - the surface with which it interfaces and the …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
… 6 (TRAF6) E3 ubiquitin ligase - to produce cellular responses such as apoptosis, survival, and inhibition of neurite outgrowth. Recently,p75NTR was also shown to undergo γ-secretase-mediated regulated intramembrane proteolysis, and the receptor ICD was found to migrate to the nucleus where …
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