Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 225 for “"Cell Morphology"”.
-
Matrix Stiffness Regulates Glial Cell Morphology and Differentiation
… of the central nervous system (CNS) and Schwann cells (SC), which perform the same function in the peripheral nervous system (PNS). The decrease of NMII activity in SC impairs their ability to establish polarity and myelinate, while its inhibition in OL enhances process branching and increases …
-
Modulation of cell morphology and function using synthetic biodegradable polymers
… into thin films for use as scaffolds for cell transplantation and guided tissue regeneration. We evaluated the ability of PLGA films to provide a suitable template for directing specific cell growth and tissue formation using cells derived from retinal pigment epithelium (RPE) as an in …
-
Investigation of Cell Morphology and Cell-Induced 3-D Matrix Reorganization
… pattern of cytoskeletal organization and cell-matrix mechanical interactions in corneal fibroblasts at the sub-cellular level. To specifically study how Rho and Rac regulate sub-cellular mechanical behavior, cells were plated inside 3-D matrices and incubated with activators and/or …
-
Fabrication of topographically patterned hydrogel substrates and their influence on cell morphology
Cell behavior is influenced by a multitude of extracellular factors including chemistry, mechanics, and geometry. Engineered microenvironments can be used to assess a wide range of such influences on cell behavior and identify parameters for future implementation into tissue engineered scaffolds. …
-
Tyrosine Phosphorylation of Villin: Effects on Actin Dynamics, Cell Morphology and Cell Migration
<p>Cell migration is a key aspect of many normal and abnormal biological processes, including embryonic development, defense against infections, wound healing, and tumor cell metastasis. In this study we demonstrate that an epithelial cell actin-binding protein, villin, plays a crucial role in the …
-
The relationship of cell morphology, density, and mechanical properties in a rigid polyurethane foam
… This work investigates the relationships between cell morphology, density, and mechanical properties in a molded polyurethane material using relatively small cylindrical molds. Understanding these relationships will help mechanical designers analyze and predict the responses of foam components …
-
Impact of polymer solution aggregation and assembly on organic solar cell morphology and device properties
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-02-04 without embargo terms
-
Uncovering the Importance of Cell Morphology, Genetic Regulation, and Neuronal Signalling in Quiescent Neural Stem Cells
Neural stem cells (NSCs) are essential for their ability to produce new neurons during neurogenesis. These cells undergo quiescence, the state when quiescent cells are metabolically active but do not produce new neurons. Understanding and manipulating this critical state is essential due to …
-
Control of protein adsorption, cell morphology and intracellular signal transduction using self-assembled monolayers of alkylthiolates on gold
… on gold have been used to interrogate cell-biomaterial surface interactions at the extracellular and intracellular level. The goal of this research was to provide molecular level information on the surface determinants necessary to produce predictable, controllable biological responses …
-
Investigation of Pyrimidine Salvage Pathways to Categorize Indigenous Soil Bacteria of Agricultural and Medical Importance and Analysis of the Pyrimidine Biosynthetic Pathway's Enzyme Properties for Correlating Cell Morphology to Function in All Phases of Growth
This dissertation comprises three parts and is presented in two chapters. Chapter 1 concerns Arthrobacter, a bacterium with an intriguing growth cycle. Whereas most bacteria exist as either a rod or coccus, this bacterium shares the rod/coccus lifestyle. It therefore seemed important to examine the …
-
Using Heterogeneous Information Sources for Understanding and Predicting Biological Effects of Compounds
… chapter, “Comparison of Structural Chemical and Cell Morphology Information for Multitask Bioactivity Predictions”, provided insights in which type of compound information is more useful in target prediction across 224 targets. The comparison was performed using cell morphology information (in …
-
The effect of cAMP elevation on intracellular signalling pathways in prostate epithelial cells
… DU145, LNCaP and PZ-HPV-7 prostate epithelial cells. Elevation of cAMP attenuated IL-6-mediated activation of STAT3 which was mimicked via selective activation of the exchange protein activated by cAMP. Inhibition of protein kinase A (PKA) alone also attenuated IL-6-induced STAT3 activation, …
-
The impact of improved materials in poly(vinyl chloride)-based endotracheal tubes
… known to invoke the proliferative phase in the cell linings. The technical objective of this work was to investigate in vitro the interaction between epithelial cells and current poly(vinyl chloride)-based ET materials, as well as some ET samples embedded with materials intended to improve …
-
A Computational Study of The Electrical Response of Biological Cells with Realistic Three-Dimensional Morphologies
One of the unique features of a biological cell is the cell membrane that protects the cell interior by establishing a physical barrier between the cytoplasm and the extracellular matrix and governs the distribution of the cytoskeleton to control the three-dimensional (3D) morphology of a cell. …
-
Osteogenic differentiation of human mesenchymal stem cells on thin film tyrosine derived polycarbonates
Mesenchymal stem cells, harvested from adult bone marrow, are promising in the field of regenerative medicine because of the vast differentiation potential into various cell lines such as: osteoblasts, chondrocytes, adipocytes, and neurons. Osteogenic differentiation of human mesenchymal stem cells …
-
Using Cell Painting and Chemical Data for Small-molecule Bioactivity and Toxicity Prediction
… predictions. The most popular among them is the Cell Painting assay, has been used alone or in combination with other - omics data to decipher the mechanism of action of a compound, its toxicity profile, and many other biological effects. Traditional approaches in drug discovery primarily rely on …
-
Optimization Techniques for Multi-object Detection and Tracking on Live-cell Fluorescence Microscopy Images and Their Applications
… and has been extensively utilized in live-cell morphology analysis. Despite its utility, related object detection and tracking tasks still face challenges due to large data scales, inferior data quality, and insufficient annotations, leading to reliance on adaptive thresholding. Current …
-
High-Frequency Irreversible Electroporation (H-FIRE) optimization for the treatment of highly invasive cells beyond the tumor margin
… While IRE will preferentially kill larger cells over smaller ones, it does not discriminate between cells with larger and small nuclei. Given that one of the hallmarks of cancer cell morphology is larger, more abundant nuclei, our team set out to explore the possibility of preferentially …
-
The FP prostanoid receptor: Isoforms and functional studies
… FP receptor isoforms, we have generated stable cell lines that express the original FP receptor, known as the FP(A) isoform and cells that express the FP(B) isoform. To date, no differences in the functional coupling between the receptor isoforms have been found. However, during the second …
Page 1 of 12