Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 617 for “"Cell Migration"”.
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Visualizing Cell Migration in Situ
Cell migration has been studied extensively by manipulating and observing cells bathed in putative chemotactic or chemokinetic agents on planar substrates. This system is attractive since the cells and their molecular components can be readily imaged and matrix and soluble parameters easily …
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Nanoparticle effects on cell migration
… found that gold nanoparticles (Au NPs) are excellent materials for biological applications such as diagnosis and drug delivery, which makes it crucial to understand the interface between gold nanoparticles and cells. Previous work has shown that gold nanoparticles can affect cellular …
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Regulation of Cell Migration by WNK1
Cell motility is an immensely complex process that involves reorganization of the cytoskeleton, and consequent membrane deformation, triggered by a variety of motogenic stimuli, including growth and chemotactic factors, hormones, and elements of the extracellular matrix. My graduate research has …
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TIS21 inhibits cell migration and invasion
… tissue, decreased BTG2 is correlated with cancer cell metastasis, suggesting that suppression of BTG2 has a critical role in cancer cell migration and invasion. When we overexpressed TIS21 in A549 cells, cell migration and invasion were dramatically inhibited. Furthermore, cell morphology was …
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Microfluidic Platforms for Investigating Cell Migration
… expression and adhesive ligation on the migration velocities of mammary breast tumor cells. Micropatterned proteins were used to titrate the relative effects of E-cadherin and Fibronectin on the migration velocities of the metastatic mammary epithelial tumor cells MDA-MB-231. These …
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RET Mediated Gene Expression and Cell-Migration
… complex formation between a member of the Glial cell line-Derived Neurotrophic Factor family of ligands and a member of the GDNF-Family Receptor α co-receptors. Upon complex formation, RET becomes phosphorylated and subsequently activates multiple downstream signaling pathways, including those …
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MECHANOPROPERTIES, HETEROGENEITY AND CELL MIGRATION IN GLIOBLASTOMA
… little is known on how it is reflected on cell migration, mechanoproperties and motility modes. Generally, the tumor cells invade the brain moving on brain vasculature or white matter tracks: Patient-Derived Xenograft (PDX) has been a standard to reproduce them in order to study GBM …
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Nanoparticle intervention for control of cell migration
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Follicular Regulatory T cell migration and differentiation
… response requires Follicular regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells located within germinal centres. Tfr cells were first characterised in detail in 2011 and because of this relatively little is known about the exact role of Tfr cells within the GC, and the mechanism/s through …
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CAMK-II: AN INTEGRAL PROTEIN IN CELL MIGRATION
… body plan. Gastrulation includes massive cell rearrangements to generate the three germ layers and shape the embryonic body. Three modes of cell migration must occur during vertebrate gastrulation and include: epiboly, internalization of the presumptive mesendoderm and convergent extension …
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Involvement of eicosanoid signalling in epithelial cell migration
… eicosanoids. Changes in the expression of extracellular matrix proteins and their related integrin receptors have also been shown to be important in the advancement IBD and CC. In light of this, we have investigated the role of eicosanoids in cell migration a key process in IBD and CC. This was …
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Regulation of Cell Migration by Integrin -Mediated Adhesion
… in regulating integrin-mediated adhesion during cell migration. The technique of mammalian cDNA expression cloning was used to identify regulators of cell-substratum adhesion. Through this approach, a cDNA with homology to RACK1, a receptor for activated protein kinase C, was identified. …
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Cell migration and alignment on mechanically controlled environment
… effect of mechanically controlled environment on cell migration and alignment in vitro. Understanding such behaviors are necessary to study wound healing of life, metastatic of cancer cells, tissue engineering, and regenerative medicines. First study is a cell migration behavior on stiffness …
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Effects of interstitial flow on tumor cell migration
… transport of fluid through tissue extracellular matrix. This creeping fluid flow has been shown to affect the morphology and migration of cells such as fibroblasts, cancer cells, endothelial cells, and mesenchymal stem cells. However, due to limitations in experimental procedures and …
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Regulation of integrin-mediated linkages during cell migration
… cytoskeletal elements and ligands to determine cell migration speed. An understanding of these parameters will aid in developing methods to control cell migration to treat diseases such as cancer, to aid wound healing, or to design tissue engineering matrices. A Chinese hamster ovary (CHO) cell …
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New roles for Hox and Wnt in Cell Migration
Neuron migration is a critical process during central nervous system development. In the dissertation below I report new roles for established genes such as Wnt and Hox, and describe roles for several new genes in neuron migration. To study migrating neurons I use the model organism nematode worm …
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Microfluidic Methods for Investigating Cell Migration and Cell Mechanics
… topology of the environment that surrounds the cell. Additionally, I sought to develop a microfluidic device able to measure mechanical properties of single cells with a sufficient throughput to account for the inherent heterogeneity of biological samples. Throughout this thesis I made use of …
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High-throughput platforms for investigating bioadhesion and cell migration
… that enabled high-throughput analyses of cell adhesion, migration, and wound healing. In this thesis, I investigated engineering design rules that determine the efficiency of thermally tunable cell adhesion and release from poly(N-isopropyl acrylamide) brushes. Large format polymer …
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Cell Migration and Survival Pathways in Cardiac Development and Disease
The file named "saxenaankur.pdf" is the primary dissertation file. All other files ("*.asf", "*.avi") are supplemental files and may be viewed individually.
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