Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Cell Manipulation"”.
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Harmonic Acoustics for Single Cell Manipulation
… that can manipulate single particles and cells in a high precision, high throughput and contact-free manner have long been motivated by applications in materials science, physics, medicine, and the life sciences. However, current single cell manipulation tools, such as atomic force …
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Microfluidics for Cell Manipulation and Analysis
… controlled handling of the flow profile and the cells in suspension. Implementation of additional forces in the system, such as an electric field, promote further manipulation of the cells. In this dissertation, I show novel, unique microfluidic approaches for manipulation and analysis of …
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On acoustic particle and cell manipulation in microfluidic systems
… new possibilities for advanced particle and cell manipulation in lab-on-a-chip applications as well as in relatively high throughput applications. Acoustic particle manipulation systems can be used e.g. to separate, wash, sort, trap or distribute particles in microfluidic networks. This …
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Development of Ultrasonic Devices for Microparticle and Cell Manipulation
An emerging demand for the precise manipulation of cells and microparticles for applications in cell biology and analytical chemistry has driven recent development of ultrasonic manipulation technology. Compared to the other major technologies used for cell and particle manipulation, such as …
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CMoS lab-on-a-chip devices for individual cell biology
… potential to integrate LOAC functionalities for cell biology applications in single chips, e.g. sensors, actuators, signal conditioning and processing circuits. In this work, after a review of the state of the art, the development of a CMOS prototype chip for individual cell manipulation and …
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Microfluidic Concentration Gradient Generation and Integrated Magnetic Sorting of Microparticles
… their feature size similar to that of biological cells, have great potential for cell manipulation and interrogation. On the other hand, the process of drug discovery involves vast amount of tests of candidate drug molecules with cells, and hence requires intensive manipulation and interrogation …
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A Novel Tele Manipulation Platform for Micro Cell Injection
Currently, cell manipulations for Intra Cytoplasmatic Cell Injection (ICSI) are performed manually. However, the success and survival rate of the cells is very low due to the great sensitivity of cells. Moreover, while manipulating, the operator cannot feel any interaction with the cells because of …
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Micro-led based optoelectronic tweezers
Micromanipulation tools are a valuable component of biomedical research. A fundamental example is in the study of the complex pathways involved in disease progression in which controlling immune cell interactions at a single-cell level is crucial to the discovery of new treatments. Current cell …
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Acoustic Standing Wave Manipulation of Particles and Cells in Microfluidic Chips
… often include small samples of particle or cell suspensions on which separation, mixing, trapping or sorting is performed. External fields and forces are used for these operations, and this thesis is specifically focused the development of ultrasonic standing wave technology and the use of …
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Characterization of a Putative Acid Phosphatase in Toxoplasma Gondii and Its Role in Parasite Propagation
… host. To replicate, the parasite must enter the cells of an infected organism where, during the invasion process, it surrounds itself with host cell membrane to form a parasitophorous vacuole (PV), within which it freely divides. To endure the intracellular environment of a host cell, Toxoplasma …
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TRP75-Mediated STAT3 Activation Promotes Anti-Apoptotic Signaling and Ehrlichia chaffeensis Infection
Ehrlichia chaffeensis is an obligately intracellular bacterium that manipulates mononuclear phagocytes by hijacking host cell signaling pathways to promote infection. In part, E. chaffeensis accomplishes host cell manipulation through the actions of secreted effector proteins, including the tandem …
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Advances in Bone Tissue Engineering
… these limitations. By combining bone forming cells, growth factors and scaffolding materials, this technique has the potential to generate custom made bone grafts. The main objectives for this thesis were to optimize the conditions for bone tissue engineering, to introduce new perspectives and …
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Three dimensional optofluidic devices for manipulation of particles and cells
… offer a powerful tool for manipulating single cells noninvasively. Integration of optical functions within microfluidic devices provides a new freedom for manipulating and studying biological samples at the micro scale. In the pursuit to realise such microfluidic devices with integrated optical …
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Design and testing of a high accuracy robotic single-cell manipulator
… built and tested a high accuracy robotic single-cell manipulator to be able to pick individual cells from array of microwells, each 30 Pm or 50 pm cubed. Design efforts have been made for higher accuracy, higher throughput, and compactness. The proposed system is designed to have a T-drive …
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Stem cell membrane engineering: an approach for modulating cell-biomaterial interactions
Cell membrane engineering is an emerging approach in the field of tissue engineering which aims to exploit the modification of cell membranes for a variety of applications including cell homing and retention, stem cell-tethered biosensors, and cell-mediated drug delivery. Compared to procedures …
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Time-dependent mechanical behavior of newly developing matrix of bovine primary chondrocytes and bone marrow stromal cells using Atomic Force Microscopy
… synthesis, assembly, and maintenance of the extracellular matrix (ECM) and yet occupy <10% of the cartilage tissue volume. Chondrocytes (equilibrium modulus, E ~ 0.3-4 kPa) develop a micrometer-thick pericellular matrix (PCM) in vivo and in vitro which is softer (equilibrium modulus, E ~40 ~ 70 …
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Theoretical Considerations of Biological Systems in the Presence of High Frequency Electric Fields: Microfluidic and Tissue Level Implications
… manipulate, isolate, and enrich rare mammalian cells dispersed within heterogeneous populations. Relevant examples of these target cells are stem cells within a differentiated population, circulating tumor cells (CTCs) in the blood stream, and tumor initiating cells (TICs) in a population of …
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Magnetic forces for surface-based bioanalysis in microfluidic devices
… Potential applications include label-free cell manipulation.
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Development of a device for multi-modal mechanical manipulation of cells in 2D and 3D engineering environment
All organisms from bacteria to cells within the human body experience some form of mechanical stimuli. The biochemical response from mechanical stimuli is known as mechanotransduction. Cell manipulation devices provide an understanding of mechanotransduction and the various signalling mechanisms …
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Magnetic Manipulation and Assembly of Multi-component Particle Suspensions
… previously unexplored concepts in magnetic manipulation including controlling the assembly of magnetic and nonmagnetic particles either in bulk fluid or near a substrate. Both uniform glass interfaces and substrates with magnetic microstructures are considered. The main goal of this work is …
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