Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 114 for “"Cell Lineage"”.
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Single-Cell Lineage Tracing Of Cancer Metastasis
… macsGESTALT, an inducible CRISPR-Cas9-based lineage recorder with highly efficient single-cell capture of both transcriptional and phylogenetic information. Applying macsGESTALT to a mouse model of metastatic pancreatic cancer, we recover ~380,000 CRISPR target sites and reconstruct …
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Transcriptional Regulation of Intestinal Stem Cell Lineage in Drosophila
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Developmental transitions of germ cell lineage of the mouse
Mammalian germ cells arise during early embryogenesis and migrate to the developing gonad where, under the direction of the somatic environment, they initiate distinct sex-specific developmental programs resulting in the production of egg or sperm. Our understanding of the molecular mechanisms …
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Molecular analysis of the Caenorhabditis elegans cell, lineage gene lin-11
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1991.
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Investigating Adult Stem Cell Lineage Specification in the Freshwater Flatworm Schmidtea mediterranea
Adult stem cells (ASCs) serve to facilitate tissue turnover during the lifespan of an organism. The goal of my research has been to deepen our understanding of how ASCs become specified towards differentiation to produce physiologically functional cell types. To this end, I have chosen to use the …
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In Vivo Studies of Ribosomal RNA Transcriptional Regulation within a Drosophila Stem Cell Lineage
… RNA gene (rRNA) transcription is critical for cell growth, proliferation and cell survival. Upregulated rRNA levels have been observed in many types of cancers. However, the extent to which rRNA transcription is differentially regulated in cells within the same lineage during differentiation in …
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The genetics and molecular biology of unc.-86, a C. elegans cell lineage gene
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1987.
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An in vitro cell lineage model to identify alterations in the differentiation program of neuroblastoma
… solid tumor that arises from trunk neural crest cells (tNCCs), a transient cell population involved in the development of the sympathetic nervous system. The tNCCs are migrating cells that differentiate into sympathoadrenal precursors (SAPs) and Schwann cell precursors (SCPs). The SAPs are the …
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The Expression of the Zinc Finger Transcription Factor zDC Defines the Classical Dendritic Cell Lineage
<p>Classical dendritic cells (cDCs) are a critical component of the immune system due to their roles in the maintenance of immune tolerance and the induction of adaptive immune responses. However, distinguishing cDCs from other myeloid populations is complicated by the lack of highly specific cDC …
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Genome-wide search for regulators of the first cell lineage decision in the mouse: a CRISPR/Cas9 endeavour
In vitro cell lines derived from the early embryo retain the identity and lineage restrictions of their embryonic counterparts: embryonic stem cells (ESCs) are pluripotent and similarly to ICM contribute to all tissues in the embryo proper, being generally excluded from the extraembryonic layer. On …
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Study of the intracellular trafficking of the pre-T-cell receptor and its role in T-cell lineage commitment
T-cell development is a complex multi-step process, driving the maturation of hematopoietic stem cells into fully functional mature T-cells that play a major role in the adaptive immune response against pathogens. This developmental process is regulated by a series of checkpoints in which the …
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Cell lineage choice during differentiation of trophoblast stem cells (tsc) is dependent on oxygen levels, and mediated by stress enzyme pathways and mitochondrial function
… into three levels----integrate, organ/tissue or cellular response. Trophoblast tem cell (TSC) is one of the earliest differentiated stem cell within blastocyst, which is the stage of preimplantation embryo developed from fertilized egg. Different from another pluripotent embryonic stem cell, …
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Frequency of leukemia types and flowcytometric immunophenotypic characterization of acute lymphoblastic leukemia presenting at the university teaching hospital, Lusaka
… were immunophenotyped as follows; 6 (42.9%) T cell lineage ALL, 6 (42.9%) B cell lineage ALL and 2 (14.2%) were Mixed lineage ALL. B cell lineage was further sub classified as follows; 4 (66.7%) were Common ALL(C ALL) while 2 (33.3%) were Mature B cell ALL. The T cell lineage was also further …
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Frequency of leukemia types and flowcytometric immunophenotypic characterization of acute lymphoblastic leukemia presenting at the university teaching hospital, Lusaka
… were immunophenotyped as follows; 6 (42.9%) T cell lineage ALL, 6 (42.9%) B cell lineage ALL and 2 (14.2%) were Mixed lineage ALL. B cell lineage was further sub classified as follows; 4 (66.7%) were Common ALL(C ALL) while 2 (33.3%) were Mature B cell ALL. The T cell lineage was also further …
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Chromatin and transcriptional regulators act in a cascade to establish a bilateral asymmetry of the C. elegans nervous system
… arises in part from left-right asymmetric cell lineages. The single left-right unpaired MI neuron is normally generated from the right side of an otherwise left-right symmetric cell lineage that on the left gives rise to the e3D epithelial cell. We performed genetic screens and isolated …
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MiRNA influences in mesenchymal stem cell commitment to neuroblast lineage development
Mesenchymal Stem Cells (MSCs) are multipotent stromal cells that can self-renew and differentiate into cells from the mesodermal cell lineage. Under specific conditions, MSCs are known to transdifferentiate into the neuronal cell lineage. The aim of this study was to investigate if specific …
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Neuroblast lineage and cell fate specification in the Drosophila central nervous system
The generation of cellular diversity during early development of nervous system is poorly understood. In the Drosophila central nervous system, cell diversity is primarily generated by the invariant lineage of neural precursors called neuroblasts. It has been proposed that a class of genes are …
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PHF6 is a novel regulator of B-cell identity in acute lymphoblastic leukemia
… PHF6 are seen in approximately 20% of adult T-cell acute lymphoblastic leukemias and 3% of adult acute myeloid leukemias. The notable absence of PHF6 mutations in B-cell lineage malignancies has led to the hypothesis that PHF6 may act as a lineage-specific tumor suppressor gene. Recent work …
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