Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 287 for “"Cell Development"”.
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An alternative B cell development program
Two major types of B cells, the antibody-producing cells of the immune system, are classically distinguished in the spleen: marginal zone (MZ) and follicular (FO). In addition, FO B cells are subdivided into FO I and FO II cells, based on the amount of surface IgM. MZ B cells, which surround the …
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ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT
B-cells are an essential part of our adaptive immune system. A network of transcription factors together with external signals facilitate the gradual developmental progression from progenitor cells towards the B-cell fate. Several key factors participating in this network have been identified. …
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Proteomic Analysis of Mammary Epithelial Cell Development
… the protein profile of the mammary epithelial cell (MEC) through different stages of mammary development. The HC11 cell line was used to investigate protein changes between undifferentiated and differentiated MEC, which represent the pregnant and lactating states of the cells. This comparison …
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Dazl regulates mouse embryonic germ cell development
In the mouse, germ cells can undergo differentiation to become either oocytes or spermatozoa in response to sex of their gonadal environment. The nature of the germ cell-intrinsic aspects of this signaling have not been well studied. The earliest known sex-specific difference in germ cells is the …
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Aspects of T cell development contributing to autoimmunity.
… breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. The work presented in this thesis was aiming at unravelling some of …
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Role of epigenetics in hematopoietic stem cell development
… as molecules which stimulate hematopoietic stem cell (HSC) formation without the need for a donor. Therefore, a study was initiated to use human-induced pluripotent stem cell (hiPSC) technology to make a patient-derived, personalized HSC. Epigenetic regulators are divided into readers, writers, …
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Olfactory Ensheathing Cell Development: A Transcriptome Profiling Approach
Olfactory ensheathing cells (OECs), the glia of the olfactory nerve, are promising candidates for patient-specific cell-mediated repair of both peripheral nerves and the spinal cord. The recent discovery that OECs originate from the neural crest, rather than the olfactory epithelium as previously …
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Molecular Mechanisms in Primordial Germ Cell Development in Zebrafish
In vielen Organismen, Primordiale Keimzellen, werden in frühen Entwicklungsstadien, entfernt von der Region wo sich die Gonaden entwickeln werden, spezifiziert. Daher müssen die Zellen zu dieser Region migrieren, wo sie sich dann in Spermien bzw. Oozyten differenzieren. Eine allgemeine Eigenschaft …
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Dynamic epigenetic modifications during human fetal germ cell development
Germ cells are responsible for transferring genetic information from parents to offspring, highlighting the significance of normal germ cell development. Epigenetic modifications, which modify gene expression without changing the underlying DNA sequence, can affect the fate of germ cells. Abnormal …
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The Influence of the Microbiota on T Cell Development
T cell development occurs in the thymus and is a complex and well-regulated process. Errors during this process can lead to immunodeficiencies and autoimmunity. This project will also look at recent thymic emigrants (RTEs). RTEs are the most immature subset and have been shown to have distinct …
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The Role of FGFR4 in Trigeminal Placode Cell Development
… neurons to the trigeminal ganglion during development of the peripheral nervous system. FGFR4 is expressed transiently in the trigeminal placode as cells undergo an epithelial-mesenchymal transition and begin to migrate toward the condensing ganglion. Because of the restricted …
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Decoding Dynamic Gene Regulation in Hair Cell Development and Regeneration
… during the differentiation of specialized cells such as mechanosensory hair cells in vertebrates' inner ears and fishes' lateral lines requires an accurate description of the time-lagged relationships between transcription factors and their target genes. Here I describe <em>De</em>picting …
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The role of conexin 43 in murine sertoli cell development
Sertoli cells are the only somatic cell type present within the seminiferous tubules of the testis. The support of these somatic cells is essential for testis formation and spermatogenesis. They are called mother or nurse cells, implicating their intimate association with germ cells and also their …
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STUDIES OF B CELL DEVELOPMENT AND V(D)J RECOMBINATION
… to produce antibodies is restricted to the B cell lineage and is tightly regulated, starting with the temporal separation of the recombination process, in which DH-JH precedes VH-DHJH recombination. Successful recombination of both heavy and light chain loci results in the expression of an …
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