Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"Cell Densities"”.
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The effect of aging on myelinating gene expression and oligodendrocyte cell densities
… changes (i.e., 2-16 months of age) in glial cell response during the recruitment (i.e., demyelination) and differentiation (i.e., remyelination) phases of myelin repair. I found that the time between 12 and 16 months of age is a critical period during which there is an age-related decrease in …
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Adult behaviour and cerebral cell densities after maternal or post-weaning consumption of an obesogenic diet in mice
Adult behaviour and cerebral cell densities after maternal or post-weaning consumption of an obesogenic diet in mice Emily Jane Mort Maternal obesity during pregnancy impairs cardiometabolic health of the adult offspring in experimental animals, and is associated with behavioural and cognitive …
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Investigation of the quorum-sensing regulon in the corn pathogen Pantoea stewartii
… bacteria migrate to the xylem and grow to high cell densities, forming a biofilm by secreting excess capsular exopolysaccharide, which blocks water transport and causes wilting. The timing of virulence factor synthesis is regulated by the cell-density dependent quorum sensing (QS) system. Such …
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Molecular, Genetic and Physiological Studies on the Regulation of Conjugal Transfer of the Ti Plasmid pTiC58 by Agrobacterium Tumefaciens
… assays determined that the bacteria mate in a cell density dependent manner, known as quorum-sensing. Analysis of transfer frequencies using a transfer-constitutive mutant of pTiC58 showed that quorum sensing requires both the opine induction and autoinduction systems. Analysis of lacZ fusions …
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Volume Changes Accompanying the Melt-Crystal Transition in Binary Borate Melts
… of the crystals were calculated using x-ray unit cell densities and volume thermal expansion coefficients obtained by high-temperature x-ray diffraction analysis. Melt specific volumes had been previously determined.
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Biology and potential biogeochemical impacts of novel predatory flavobacteria
… when growing predatorily. Olleya sp. predatory cells accumulated to an order of magnitude greater cell densities than Tenacibaculum sp. cells on equivalent prey cell densities. Experiments were conducted to constrain the potential of the novel isolates to affect prey communities under more …
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Biology and potential biogeochemical impacts of novel predatory flavobacteria
… when growing predatorily. Olleya sp. predatory cells accumulated to an order of magnitude greater cell densities than Tenacibaculum sp. cells on equivalent prey cell densities. Experiments were conducted to constrain the potential of the novel isolates to affect prey communities under more …
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Genetic Analysis of the Quorum Sensing Regulator EsaR
… a capsular exopolysaccharide (EPS) at high cell densities. The production of EPS is regulated by an EsaI/EsaR quorum sensing mechanism, homologous to the LuxI/R system. Although activation of the EPS encoding genes by EsaR occurs after it complexes to the AHL (3-oxo-C6-HSL), unlike the …
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A Bottom-Up Assembly Of Vascularized Bioartificial Constructs Using Ecm Based Microscale Modules
… is to fabricate a 3D construct that can promote cell-cell interaction, extra cellular matrix (ECM) deposition and tissue level organization. Accomplishing these prerequisites with the currently available conventional scaffolds and fabrication techniques still remains a challenge. To reproduce the …
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Structure/Function Analysis of the Quorum-sensing Regulator EsaR from the Plant Pathogen Pantoea stewartii
… symptoms develop after the bacteria grow to high cell densities in the plant xylem and secrete an abundance of exopolysaccharide (EPS). EPS production is regulated by quorum sensing. Two regulatory proteins are key to the process of quorum sensing, the LuxI and LuxR homologues EsaI and EsaR. Most …
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Establishment of a novel Pichia Pastoris host production platform
The Cell Line Development group at Amgen is responsible for manufacturing and optimizing the cell lines utilized in production of Amgen's biologic drug portfolio. Traditionally, these cell lines are produced from mammalian host organisms, primarily Chinese Hamster Ovary (CHO) cells, due to their …
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Design of a cultivation medium for protein production in Pichia pastoris based on genome-wide biological understanding
… Its fast growth rate and ability to grow to high cell densities can enable fast production cycles, agile process development, and potentially low production costs. While P. pastoris has already been engineered to produce antibodies with human-like glycoforms, titers are still lower than those …
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IGE PRODUCTION REGULATION VIA CD23 STALK ENGAGEMENT AND CELL CYCLE STIMULATION
… receptor for IgE, is expressed mainly on B cells and has been shown to regulate IgE production. Previously, recombinant mouse and human CD23 were constructed with a trimerizing isoleucine zipper motif attached in frame to the N-terminus of the entire extracellular CD23 (lz-ECCD23). The goal …
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Evaluating mitochondrial uncoupling potentials of A7E and DNP in Saccharomyces cerevisiae : implications for human obesity
… Microbial staining was used to ascertain cell viability and any changes in cell densities. ATP production was estimated by measuring luminosity generated in culture supernatants using the ATP Bioluminescence Kit (Sigma St. Louis, MO.). RESULTS: Luminosity measurements estimating ATP …
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Mapping the spatial organisation of B cells and immune signalling in TNBC to characterise response to immunotherapy
In recent years, B cells and tertiary lymphoid structures (TLS) have emerged as key predictors of immunotherapy response across multiple cancers. B cells exist in various states of spatial organisation within the tumour microenvironment (TME), which likely support many of their functional roles. …
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System to study colony-colony interactions in embryonic stem cells
… involved in self-renewal of embryonic stem cells (ESCs). Recent studies suggested that different autocrine factors exist in murine ESCs (mESCs) and can influence their self-renewal and proliferation, predominantly in deficiency conditions. These observations were investigated based on a …
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Quorum sensing for improved production of industrially useful products from filamentous fungi
Quorum sensing (QS) is a cell density dependant phenomena utilized as a communication process among microorganisms to regulate their physiological responses. QS depends on the production and release of low molecular weight, diffusible chemical signalling molecules, known as quorum sensing molecules …
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Investigation of mesophilic Aeromonas: response to hydrogen peroxide and role in false-positive Colilert reaction.
… production of falsepositive reaction at high cell densities (Edberg et ai., 1988). Similar results were obtained in our study when using fresh Colilert reagents. However, results obtained during this project showed Aeromonas to mediate false-positive reactions at low cell densities (101 …
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Phenotypic and Genotypic Characteristics for Escherichia coli strains responsible for bacterial bloom events in Australia
… elevated counts of 10,000 - 100,000 cells/100 ml of water (bloom events) are reported from freshwater reservoirs and recreational lakes in Australia. Bloom strains are not faecal associated and may represent free-living E. coli. A limited number of strains are responsible for bloom …
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Phenotypic and Genotypic Characteristics for Escherichia coli strains responsible for bacterial bloom events in Australia
… elevated counts of 10,000 - 100,000 cells/100 ml of water (bloom events) are reported from freshwater reservoirs and recreational lakes in Australia. Bloom strains are not faecal associated and may represent free-living E. coli. A limited number of strains are responsible for bloom …
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