Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1649 for “"Cell Death"”.
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Role of Bcl-xL in Doxorubicin-Induced Cell Death: Apoptosis and Mitotic Cell Death
Bcl-xL overexpressed in various human cancer cells contributes to resistance against various chemotherapeutic agents. In this study, we compared the role of Bcl-xL in high dose (HD) doxorubicin-induced apoptosis and low dose (LD) doxorubicin-induced mitotic cell death. In the first part of this …
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Monoamine oxidase in neuronal cell death
… (ROS) contribute to oxidative stress in the cell and can directly inhibit electron transport, cause damage to mitochondrial DNA and enhance cell death signalling. In this study the role of MAO in cell death was investigated in dopaminergic neuroblastoma (SH-SY5Y) cells, in three diverse …
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STAUROSPORINE-INDUCED APOPTOSIS/PROGRAMMED CELL DEATH
Apoptosis is the mechanism by which cells are programmed to die under a wide range of physiological and developmental stimuli. Three phases of the apoptosis process, (a) induction phase, (b) commitment phase and (c) degradation phase, have been described in interphase cells only. This study …
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Influenza A Virus Induced Programmed Cell Death
… epidemics that can result in up to 50000 deaths and 700000 hospitalizations each year, and ranks in the top ten causes of death in the United States. In addition, virulent strains of IAV have caused pandemic outbreaks triggering numerous fatalities. While tropism to the upper respiratory …
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Autophagy in Metabolism, Cell Death, and Leukemogenesis
… nutrient uptake and prevent apoptosis. Cancer cells, however, can express constitutively active oncogenic kinases such as BCR-Abl that promote these processes independent of extrinsic growth factors. When cells are deprived sufficient growth signals or when oncogenic kinases are inhibited, …
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Reactive Oxygen Species-Induced Necrotic Cell Death
Mechanisms of cell death extend beyond the simple apoptosis/necrosis relationship to include regulated modes of cell death that do not readily fit either of the classic descriptors. One such mechanism of cell death involves poly(ADP-ribose)polymerase-1 (PARP-1)-mediated cell death. …
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Regulation of BAX/BAK-Dependent Cell Death Program
… regulation of a genetically programmed apoptotic cell death that involves mitochondria. Diverse apoptotic signals converge on mitochondria, which causes the release of cytochrome c into the cytosol to activate Apaf-1. This initiates caspase activation, which results in irreversible cellular …
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Cell Death Mechanisms in Drosophila Differentiated Photoreceptor Neurons
<p>Apoptosis, or programmed cell death, is a form of physiological cell death that is essential for normal development and homeostasis. At the end of pupal development of the Drosophila retina, cell death terminates and photoreceptor neurons complete their differentiation process. We use these …
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Control of Programmed Cell Death by GCN-1
Apoptosis is a cell death phenomenon that is fundamental to the development of an organism and to the pathogenesis of disease states. Regulation of apoptosis occurs at various molecular steps, but its regulation at the translational level remains poorly understood. The phenomenon of germline …
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Bax-mediated coordination of cognate organelle cell death signaling cascades determines cell death phenotype after trauma in the neonatal rat cortex
… has been well-characterized to induce apoptotic cell death in multiple injury paradigms. However, pro-cell death actions for Bax outside of the mitochondria remain understudied. Bax’s pro-cell death role at other non-mitochondrial locales in response to oxidative stress and energy depletion …
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Investigation into the role of DWNN in cell death
… influence the self-destruction programme of the cell. This programme entails synchronised instigation and implementation of numerous subprograms. The arrival of gene targeting aided in the determining of the functions of novel genes. Such genes may have been sequenced, but not functionally …
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Phenothiazines Induce Abortive Autophagy Leading to Cancer Cell Death
… and environmental stresses for the survival of cells by delivering cytoplasmic contents to the lysosomes for recycling and energy generation. Dysregulation of this process has been linked to human diseases including immune disorders, neurodegenerative muscular diseases and cancer.</p> …
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IAP antagonist Grim mediates cell death through divergent pathways
… proteases (caspases), which in turn cause cell self-destruction. While caspases are activated upon various death stimuli or developmental cues, inhibitor of apoptosis (IAPs) can prevent caspase-mediated cell death, not only through direct binding and inhibition, but also by directly …
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Host cell death in Legionella pneumophila pathogenesis and immunity
<p><em>Legionella pneumophila</em> is an intracellular pathogen that causes a severe, atypical pneumonia termed Legionnaires' disease. Upon entering the host cell, <em>L. pneumophila</em> resides in a membrane-bound vacuole, in which the bacterium evades lysosomal fusion and replicates. The …
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Development of imaging techniques to assess tumour cell death
Cell death is an important imaging target for assessing early tumour treatment response and the effectiveness of therapy. Traditionally, anatomical imaging modalities measure changes in tumour size (Response Evaluation Criteria in Solid Tumours (RECIST)). More recently these assessments have also …
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Genetic analysis of programmed cell death in Drosophila melanogaster
The correct regulation of programmed cell death, or apoptosis, is critical for proper development and prevention of disease. Components of the molecular mechanisms that govern apoptosis are conserved among organisms as diverse as C. elegans, Drosophila, and mammals. A central step in the execution …
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Molecular studies of Fas signaling and programmed cell death
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Cell Death Characterization In Tumor Constructs Using Irreversible Electroporation
… short, pulsed electric fields to damage cell membranes leading to cell death. The therapy is minimally invasive, involving the insertion of needle electrodes into the region of interest and lasts less than two minutes. Heat sink effects that thermal therapies experience near large blood …
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