Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Cell Cycle Proteins"”.
-
Protein-Protein Interactions in Cell Cycle Proteins: An <i>In silico</i> Investigation of Two Important Players
<p>The examination of the cell cycle carries significant implications for the biology, health, and overall existence of all living things. These implications span from the development and growth of these organisms to the aging process and cancer, as well as the potential of stem cell therapies to …
-
Study of the cell cycle interactome of Arabidopsis thaliana through a targeted proteomics approach
… is critical to virtually all aspects of cell biology, because many cellular processes are regulated by stable protein complexes and their identification often provides insights into their function. In the introduction of the thesis, an overview is given on proteomic approaches with an …
-
Cell Cycle Regulation and Cancer: The Emerging Role of KIAA1143
Proper regulation of the cell cycle checkpoints is essential for ensuring the accurate progression of each phase. When abnormalities occur in the proteins governing these checkpoints, diseases such as cancer frequently arise. These checkpoints include the G1/S transition, where cancer-associated …
-
Investigating The Interaction of Aurka and Ube2C In Colorectal Cancer Cells
… immunoblotting experiments in a panel of ten CRC cell lines showed high positive correlation between endogenous protein expression of UBE2C and AURKA. Overexpression of AURKA led to an increase in UBE2C protein as well as transcript levels, although UBE2C protein levels remained stable when cells …
-
Specific, Reversible Cytostatic Protection of Normal Cells Against Negative Effects of Chemotherapy
… cancer chemotherapeutics target proliferating cells and tissues, all dividing cells, whether normal or tumor, are affected. Cell culture studies have demonstrated that UCN-01 is able to reversibly and selectively arrest normal dividing cells; tumor cells lines do not undergo this temporary …
-
Multiple Functions of BRD4 in E2 Mediated HPV Transciptional Regulation
… origins. Expression of HPV-encoded E6 and E7 oncoproteins is controlled by the viral E2 protein, which plays a dual role in gene activation and repression. Recently, we identified bromodomain-containing protein 4 (Brd4) as a cellular corepressor for E2-mediated inhibition of HPV transcription. …
-
Differential Activity of The Kras Oncogene By Method of Activation: Implications For Signaling and Therapeutic Intervention
… mutations. An isogenic panel of colorectal cells with wild type KRas replaced with KRas G12C, G12D, or G12V at the endogenous loci differed in sensitivity to Mek and Akt inhibition. In contrast, screening was performed in a broad panel of lung cell lines alone and no correlation was seen …
-
Cohesin Promotes the Myelination Transcriptional Program in Oligodendrocytes
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
The direct effects of estradiol and several xenoestrogens on cell numbers of early- vs. late-stage prostate cancer cells
… for potential future therapies, we identified cellular pathways and rapid signaling events that act via estrogen receptors (ERs) and contribute to estradiol (E2) or DES-mediated cell killing/growth arrest. E2 was much more effective than DES at reducing cell numbers of both LAPC-4 early-stage …
-
Echogenic Liposomes For Nitric Oxide Delivery and Breast Cancer Treatment
… (NO) gas into ELIP, deliver it to breast cancer cells, and control its release via direct ultrasound exposure. Studies on the effect of NO in tumor biology have shown that a high levels of NO (> 300 nM) leads to cytostasis or apoptosis by decreasing the translation of several cell cycle proteins …
-
Functional Analysis of the Human SMC5/6 Complex in Homologous Recombination and Telomere Maintenance
… maintenance of chromosomes (SMC) family of proteins has been implicated in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). The SMC1/3 cohesin complex promotes HR by localizing to DSBs where it holds sister chromatids in close proximity to allow HR-induced …
-
On Sulfur Sensing in Saccharomyces cerevisiae
… many of the biochemical reactions requisite for cellular life possible. As a result of this critical importance, organisms have developed several mechanisms for sensing and maintaining levels of sulfur-containing metabolites. In the yeast Saccharomyces cerevisiae, regulation of sulfur metabolism …
-
Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance
… subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. In addition, we have studied the functional retinoblastoma tumour suppressor (RB) protein pathway and associations to tamoxifen response. Furthermore, the expression of …
-
Structural and Molecular Mechanisms of Centrosome Assembly and Strength
… coiled-coil interactions between SPD-5 proteins.
-
Regulation of Sister-Chromatid Cohesion
… execution of two critical events during the cell cycle--DNA replication and chromosome segregation--ensures the stable transmission of genetic materials. The cohesin complex physically connects sister chromatids during DNA replication in a process termed sister-chromatid cohesion. Timely …
-
The role of conexin 43 in murine sertoli cell development
Sertoli cells are the only somatic cell type present within the seminiferous tubules of the testis. The support of these somatic cells is essential for testis formation and spermatogenesis. They are called mother or nurse cells, implicating their intimate association with germ cells and also their …
-
A study of the relationship of the internal endocrine environment to the p53 network, cyclin D1 and replication licensing proteins in breast cancer
… of cyclin D1 and replication licensing proteins (mcm2 and geminin) in invasive breast cancer. Hypothesis The endocrine environment may be critical in the development and efficacy of treatment in breast cancer. Oestrogen has the potential to modulate the function of p53 network and cell …
-
Studies of the Molecular Features of Brd4-Nut and P300 That Contribute to Condensate Formation and Transcriptional Regulation
… to mimic the transcriptional profile of cells expressing Brd4-Nut. My results suggest that interaction of Brd4-Nut with p300 is important for aberrant condensate formation, and that multiple, yet distinct, regions of p300 contribute to condensate formation and transcriptional regulation.
-
Defining Tumorigenic Contributions of Meiotic Cancer-Testis Antigens
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
The Multifunctional Kinase Bub1 Acts as a Signaling Hub for the Spindle Checkpoint
… Bub1 recruits other important checkpoint proteins like BubR1, Mad1 and Cdc20. We found phosphorylation on Bub1 serine 459 is essential for spindle checkpoint and for Bub1-Mad1 interaction. However, the majority of Mad1 still localize to the kinetochore in cells expressing Bub1-S459A …
Page 1 of 2