Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1645 for “"Cell Biology"”.
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Transcriptional regulators in stem cell biology
Adult stem cells support tissue regeneration by both self-renewing and differentiating into specialized cell types. Analogous self-renewal and differentiation processes enable cancer stem cells to promote tumorigenesis. Transcriptional modulation, enacted by proteins including epigenetic regulators …
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Cell Biology of Foxp3+ Regulatory T Cells
<p>T cells play a central role in the immune response to fight against pathogens and orchestrate other immune cells. An overreactive immune response can lead to autoimmune diseases, therefore the immune system must possess negative regulation mechanisms. In the periphery, naturally arising …
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Computational Methods for Investigating Dendritic Cell Biology
… response results from the interplay of two cellular systems: the innate immunity and the adaptive immunity. In the past decades, dendritic cells have emerged as major players in the modulation of the immune response, being one of the primary links between these two branches of the immune …
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Engineering mesoporous silicon for cell biology applications
… structure of porous silicon is of interest for cell biological applications due to the large surface area and optical properties. To render the material biocompatible we modify porous silicon using hydrosilylation and bioconjugation techniques to render it inert to degradation and allow for cell …
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Using light to control and investigate cell biology
… tool for the interrogation of molecular and cellular biology. Beyond its use in microscopic applications, light has emerged as an attractive modulator of cellular function. Within the last two decades, scientists have begun to harness the power of light and light-sensitive moieties to …
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The role of complex gangliosides in glial cell biology
… rafts and are thought to be involved in numerous cellular events, including proliferation, differentiation, migration and neurite outgrowth. Gangliosides have also been shown to have neuroprotective actions and have been considered as candidates for the treatment of several neurodegenerative …
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Phase imaging with computational specificity for cell biology applications
… built upon the principle of PICS, to detect the cell cycle of live cell clusters. We demonstrate that the proposed method can be applied to study single-cell dynamics within the cell cycle as well as investigate cell biophysical parameter distribution across different stages of the cell cycle.
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The role of mitochondrial complex II in cancer cell biology
Mitochondrie jsou pro většinu eukaryotických buněk nezbytné organely, které obsahují řadu komplikovaných, vzájemně interagujících proteinových struktur. Mezi ně patří mimo jiné i komplexy elektron transportního řetězce, tedy komplexy I - IV. Mitochondriální komplex II hraje klíčovou roli v buněčném …
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Cell Biology of the ICA69 protein family in Neurosecretory cells
… microvesicles. Thus, the study of beta-cell autoantigens with yet unknown function may provide novel insight into the secretory machinery of beta-cells and led to the discovery of novel pathways. Islet cell autoantigen of 69 kDa (ICA69) is a T1D autoantigen. It is a cytosolic protein of …
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CMoS lab-on-a-chip devices for individual cell biology
… potential to integrate LOAC functionalities for cell biology applications in single chips, e.g. sensors, actuators, signal conditioning and processing circuits. In this work, after a review of the state of the art, the development of a CMOS prototype chip for individual cell manipulation and …
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Cell biology of settlement and adhesion processes of biofouling algae
… presented in this thesis was to investigate the cell biology behind the settlement and adhesion processes of biofouling algae. Using the fluorescent dye FM 1-43 in Ulva zoospores to follow membrane recycling, rapid mass membrane retrieval of FM 1-43-labelled plasma membrane was found to occur to …
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Reasoning from experiments to causal models in molecular cell biology
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.
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In silico cell biology and biochemistry: a systems biology approach
In the post-"omic" era the analysis of high-throughput data is regarded as one of the major challenges faced by researchers. One focus of this data analysis is uncovering biological network topologies and dynamics. It is believed that this kind of research will allow the development of new …
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Functional cell biology and molecular pharmacology of ATP sensitive potassium channels.
… potassium channels (K ATP) transduce changes in cellular metabolism into changes in membrane potential. Activation of K ATP channels causes vascular smooth muscle to hyperpolarize. This leads to a relaxation of the pre-contracted muscle. Inhibition of K ATP channels produces membrane …
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New Roles of the Transcription Factor NKX6.1 in Beta Cell Biology
Pancreatic islet beta cells play a critical role in the maintenance of metabolic fuel homeostasis. Type 1 diabetes results from autoimmune destruction of the beta cells, whereas type 2 diabetes involves loss of beta cell function, particularly glucose-stimulated insulin secretion (GSIS), and a …
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A study of invariant NKT cell biology in health and disease
Invariant NKT cells (iNKT cells) have been increasingly recognised as an important cell type in regulating certain immune responses. Advances in the understanding of iNKT biology have provided opportunities for manipulating their functions for combating malignant, infective and autoimmune diseases. …
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Hdac3 is a Critical Regulator of Neural Crest Progenitor Cell Biology
… coordinated development of multiple progenitor cell pools. Specific transcriptional programs regulate the specification, expansion, migration and eventual differentiation of these progenitor cell populations, and tight control of these programs is essential for normal development to occur. Class …
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Monitoring single heart cell biology using lab-on-a- chip technologies
… structures for the analysis of single cells; however, substantially less work has focused on developing "active" assays, where the cell‘s metabolic and physiological function is itself controlled on-chip. The heart attack is considered the largest cause of mortality and morbidity in the …
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