Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Cell Aggregation"”.
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Red Blood Cell Aggregation Characterization: Quantification and Modeling Implications of Red Blood Cell Aggregation at Low Shear Rates
Red blood cells (RBCs) are the most abundant cells in human blood, representing 40 to 45% of the blood volume (hematocrit). These cells have the particular ability to deform and bridge together to form aggregates under very low shear rates. The theory and mechanics behind aggregation are, however, …
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Morphogenetic Movements Contributing to Cell Aggregation in Dictyostelium Discoideum Wild-Type and Streamer F Mutants
We investigated some cell processes which may contribute to cell aggregation patterns in the social ameba Dictyostelium discoideum. Aggregation is known to be mediated by chemotaxis up periodic extracellular cAMP gradients; however, the details of cell movement during this stage of development have …
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The role of platelets and leukocytes in endogenous fibrinolysis.
The impact of intravascular aggregation of circulating platelets and white blood cells on the plasma activity of t-PA and PAI-1 was measured. In vivo platelet and white blood cell aggregation was induced by platelet and white blood cell agonists, the effect being monitored by the Technicon …
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Investigating Notch/Dll4 signalling in retinal microvascular cells in health and disease
Endothelial cells, which form the inner lining of all blood vessels, maintain various critical functions to enable the efficient transport of oxygen and nutrients to all metabolising cells of the body. Finely tuned regulation of endothelial function is important for the establishment and …
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Studies of the cell biological function of the Amyloid Precursor Protein (APP) family in Drosophila melanogaster and mammals
… and is pathologically characterized by extracellular Amyloid plaques and intracellular neurofibrillary tangles are the main pathological features of AD. Amyloid-beta, the main protein constituent of Amyloid plaques, is derived from the Amyloid Precursor Protein (APP) by proteolytic …
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Yeast flocculation: understanding cell surface structure-function relationships in industrial yeast strains
… or substrate invasion, biofilm formation and cell-cell aggregation. One of such controlled forms of cellular adhesion in yeast that occurs preferentially in the liquid environments is a process of asexual aggregation of cells which is also referred to as flocculation. The timing during growth …
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Structural Basis of the Tensile Strength of Protein Complexes Mediating Cell Adhesion
… explores the behaviour of adhesive complexes of cell adhesion molecules undergoing forced detachment. Molecular-forces measurements combined with Steered Molecular Dynamic (SMD) simulations were used to investigate the mechanical response of the CD2 C58 and hemophilic C-cadherin bonds. The …
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Kinetics and regulation of the initial stages of cadherin-mediated adhesion
Cell adhesion plays a critical role in development, and in the maintenance of tissue integrity. Cadherins are calcium-dependent adhesion proteins which mediate cell adhesion in soft tissues. Several theories have been offered to explain the mechanism of cadherin adhesion. The first proposed …
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Structure and function of the R2B adhesive receptor tyrosine phosphatases
… phosphatases (PTPs) are key regulators of cellular signalling through the control of cellular phosphotyrosine levels. The R2B family of receptor-like PTPs – PTPRK, PTPRU, PTPRM and PTPRT - are well placed on the plasma membrane at sites of cell-cell contact to influence cell adhesion. …
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Modeling mammary epithelial cell polarization and the role of podocalyxin in breast tumor progression
… in vitro by culturing mammary epithelial cells as 3D spheroids embedded in a reconstituted basement membrane. I first used this assay to characterize the role of cell-cell and cell-ECM adhesion in the formation and polarization of the apical junction complexes in normal mammary epithelial …
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Active Inhibition of T Cell Proliferation by Monocytes
… well described in their ability to inhibit T cell activation. The most current model is that anti-class II mAb interfere directly with the T cell receptor-major histocompatibility complex crosslinking which is necessary for T cell activation. The anti-CD3 mAb, OKT3, is an MHC class II …
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Isoform-specific Loss of CD44 Interferes with Different Aspects of the Metastatic Process
The cell-cell and cell-matrix adhesion molecule CD44 and its numerous splice variants are involved in a multitude of physiological and pathological processes, including tumour progression. Especially variant CD44 has been implicated in metastasis formation. For long term in vivo experiments on …
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Γονιδιακή κλωνοποίηση μορίου κυτταρικής συνάφειας του νευρικού συστήματος
… and identification of biological function of the cell adhesion molecules in the nervous system of vertebrates and invertebrates will be the guide to our understanding of the molecular mechanisms involved in the development of the nervous system (cell migration, differentiation, cell aggregation, …
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Investigation of the antibacterial activity of selected flavonoids.
… assays as a guide, galangin was shown to cause aggregation of bacterial cells. These results indicate that galangin-induced decreases in colony counts of S. aureus observed in time-kill assays are caused by cell aggregation or a combination of cell aggregation and cell death, and call into …
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Cadherin recognition and specificity
Cadherins are calcium dependent cell adhesion molecules. The interaction between cadherin molecules is important in establishing cell polarity, tissue identity and tissue boundary. This study focused on the mechanism of cadherin mediated cell-cell interaction and binding specificity. First, the …
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Cadherin specificity in adhesion and mechanotransduction
Cadherins mediate Ca2+ dependent cell-cell junction in all animal tissues. Tight regulation of cadherin adhesion plays critical roles in diverse biological processes. Differential binding between cadherin subtypes is widely believed to mediate cell sorting during embryogenesis. However, a …
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Rheological Aspect of Cell-Free Layer Formation in Micro-blood Flow: Experimental and Numerical Study
… detailed insight into the rheological aspects of cell-free layer (CFL) formation in micro-blood flow and its relation to red blood cell (RBC) aggregation. Both experimental and computational approaches were utilized in characterizing the relationship between the CFL width change and RBC …
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Human colon cell migration and socialization induced by small RNA nucleotides
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Role of androgens in testicular development and dysgenesis
… or in young adulthood (testicular germ cell cancer and low sperm counts), are common and may be increasing in incidence. These disorders have a common fetal origin and share risk factors; consequently they are hypothesized to comprise a testicular dysgenesis syndrome (TDS). TDS arises …
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