Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 591 for “"Cell Adhesion"”.
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Molecular Mechanisms of Cell Adhesion
… its terminal domains Ig1 and Ig2. When NCAM of cell A and cell B connect to each other through complexes Ig12(A)/Ig12(B), the relative mobility of cells A and B and membrane tension exerts a force on the Ig12(A)/Ig12(B) complex. Here we investigate the response of the complex to force, using …
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Molecular Basis of Cell Adhesion Mechanics
Adhesive interactions between cells in multicellular organisms play a significant role in the development and maintenance of compact tissue structures. Cell adhesion depends on specialized adhesion molecules on the cell surfaces. Recent developments studying physical and chemical properties of the …
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Liver Cell Adhesion Molecules in Embryonic Development
<p>Cell-cell adhesion is one of the essential processes for normal embryogenesis. The isolation and characterization of the neural cell adhesion molecule, N-CAM, provided the first substantial opportunity to study this process at a molecular level. Moreover, studies of N-CAM expression in embryos …
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Stochastic dynamics of cell adhesion in hydrodynamic flow
… between hydrodynamic transport and specific adhesion is theoretically investigated. An important biological motivation for this work is the rolling adhesion of white blood cells experimentally investigated in flow chambers. There, specific adhesion is mediated by weak bonds between …
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Differential Expression of Cell Adhesion Molecules by Neuronal Injury
Cell adhesion molecules(CAMs) are expressed in glial cells and neurons play critical roles in development and maintenance of nervous system. CAMs are reported that may be key molecular determinants in the response of the nervous system to injury. Therefore we are thought to that the expression of …
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Homophilic and Heterophilic Interactions Among Cadherin Cell Adhesion Molecules
… over heterophilic binding that would explain the cell sorting behavior.
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Mechanisms of cell adhesion regulation by herpes simplex virus
… proteins that extensively remodel the host cell. Three such proteins are pUL21, pUL7 and pUL51. pUL21 is a viral phosphatase adapter. pUL7 and pUL51 form a complex that localises to juxtanuclear membranes and sites of cell-matrix adhesion termed focal adhesions. All three proteins are …
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Profiling muscle stem cell adhesion using extracellular matrix peptide arrays
… aged SkM contains lower levels of certain extracellular matrix (ECM) components that are critical for proper adhesion of muscle stem cells (MuSCs), which are responsible for muscle regeneration. These observations support the notion that peptides derived from ECM proteins containing the …
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Synergism of Gingipains in Endothelial Cell Adhesion Disruption and Apoptosis
… the effects of these proteases on endothelial cells, we exposed bovine coronary artery endothelial cells (BCAEC) and human microvascular endothelial cells (HMVEC) to gingipain-active extracellular protein preparations and/or purified gingipains from <em>P. gingivalis. </em>Treated cells …
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Self Assembling Bioactive Materials for Cell Adhesion in Tissue Repair
… liquid crystalline phases when cast as a film. Cell culture experiments on these films with 3T3 and 3T6 fibroblasts indicated that these ordered materials form surfaces with specific chemistries that favored cell adhesion, spreading, and proliferation suggesting the potential of mediating human …
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Photonic crystal enhanced microscopy for imaging of live cell adhesion
… (EF) imaging modalities for the study of cell-surface interactions and nanoparticle-based assays. The imaging system utilizes an angle-tunable illumination source, either LED or laser, to achieve highly efficient coupling of incident light to PC optical resonances. Detection of the …
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Reexamining actin polymerization in maintaining cadherin mediated cell-cell adhesion
Inhibiting actin polymerization disrupts the cell-cell junction showing that continuous actin polymerization is required for maintaining tissue cohesion. The actin cytoskeleton maintains cell-cell cohesion by converting weak homophilic bonds between the cadherin cell adhesion molecules into strong …
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The role of PTPRF and PTPRK in regulating cell adhesion
… phosphatases (RPTPs) are critical regulators of cell signalling and communication, controlling cellular phospho-tyrosine (pTyr) levels and playing essential roles in tissue morphogenesis. Plasma membrane RPTPs are well positioned to sense external environmental cues, such as cell-cell contact, …
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Optimization of cell adhesion environments for a liver cell bioreactor
… such as drug toxicity models and biosensors. Cell adhesion is an important factor in the maintenance of differentiated hepatocyte functions. Hepatocyte adhesion environments were examined in two settings: spheroid culture prior to seeding in the bioreactor and 2D surface culture methods that …
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Analysis of Band 4.1B In Integrin-Mediated Cell Adhesion and Signaling
… adaptor protein that regulates various cellular behavior; however, the mechanisms by which Band 4.1B contributes to intracellular signaling are unclear. This project addresses in vivo and in vitro functions for Band 4.1B in integrin-mediated cell adhesion and signaling. Band 4.1B has …
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Regulation of Cell Adhesion By The Ferm Proteins, Ptpn14 and Merlin
<p>Cell-cell adhesion is critical for the control of tissue organization and homeostasis. A family of proteins that regulate cell-cell adhesions is the FERM (<strong>4</strong>.1 protein, <strong>E</strong>zrin, <strong>R</strong>adixin, <strong>M</strong>oesin) domain-containing proteins.One FERM …
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Functional analysis of ICAM-1 : LFA-1 interaction in cell adhesion
… the use of a soluble form of ICAM-1 to inhibit cellular immune responses, which in general rely heavily on the interaction between the counter receptors ICAM-1 and LFA-1, and aimed secondly at studying the mechanisms regulating ICAM-1:LFA-1 mediated cell adhesion. Functional characterization of …
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Molecular Mechanisms of Circulating Tumor Cell Adhesion in Breast Cancer Metastasis
During hematogenous metastasis, tumor cells dissociate from a primary tumor, migrate through the tissue space, and enter the circulatory system. The circulating tumor cells (CTCs), once bloodborne, travel to distant sites, where they adhere to the endothelial cells lining the vessel wall, …
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Plasticity in mice nociceptive spinal circuits -role of cell adhesion molecules.
… have to deal with complex issues related to intercellular communication, e.g. plasticity in neuronal networks. To provide a basis for such studies, the present thesis compares basic features of the nociceptive spinal systems including the organization of nociceptive withdrawal reflexes (NWR), …
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