Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Cell & Molecular"”.
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Integrated computational and experimental analysis of non-neuronal cell molecular mechanisms contributing to Alzheimer's disease progression
… there has been focus on non-neuronal cells, mechanisms by which they affect neurotoxicity, and their varied roles in disease progression. In this thesis, we apply systems techniques towards ADrelevant omics datasets to generate new hypotheses regarding non-neuronal cell contributions …
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Massively multiplexed imaging probes for comprehensive single-cell analysis
… microscopy techniques are widely used to study cellular physiology in their native tissue environments. In particular, the use of fluorescent probes to tag different cell populations, subcellular compartments, specific proteins and nucleotide sequences has enabled examination of cellular …
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Discrete 3D Model of Molecular Diffusion Through the Nuclear Pore Complex
… within the nuclear envelope (NE) of a eukaryotic cell. Molecular cargo travel through the passageways to either import to the nucleus or export to the cytoplasm of the cell. Efficient export of certain cargo is necessary for maintained health of a cell, and hence, the organism. Traditional methods …
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Shock compression and flash-heating of molecular adsorbates on the picosecond time scale
… employed to monitor vibrational transitions of molecular adsorbates on metallic substrates during laser-driven shock compression and flash-heating. Adsorbates were in the form of well-ordered self-assembled monolayers (SAMs) and included molecular explosive simulants, such as nitroaromatics, and …
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Wideband and fast THz spectrometer using dual-frequency-comb on CMOS
… the impacts of various noise mechanisms, gas cell, molecular properties, detection sensitivity, etc. The spectrometer utilizes two counter-propagating frequency-comb signals to seamlessly scan the broadband spectrum. The comb signal, with 10 equally-spaced frequency tones, is generated and …
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Dynamic Characterization of the IKK:κBα:NFκB Negative Feedback Loop Using Real-Time Bioluminescence Imaging
… factor NF-κB is a pivotal regulator of mammalian cell function, modulating genes implicated in cellular stress responses, proliferation, differentiation, cell survival and apoptosis, as well as immune and inflammatory responses. Improper regulation of NF-κB signaling has been implicated in a …
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Revised - THE ROLE OF GAD67/65 IN THE THERAPEUTIC EFFECTS OF KETAMINE AND FLUOXETINE IN FEAR-CONDITIONED MICE
… inhibitory influence on excitatory pyramidal cells (PCs) throughout the amygdala, hippocampus, and PFC. This study quantified the expression GAD67/65 in brains harvested from mice that underwent FC and drug treatment from a previous published study conducted in our laboratory. Specifically, …
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Exploiting Multi-Cell Type Cultures to Elucidate Tumor Cell Features That Impact Macrophage Phenotype
… and women. Lung cancer is divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) which represent 80-85% and 15-20% of cases, respectively. My dissertation project focused on understanding how to model the interactions between lung cancer cells, fibroblasts and immune …
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Quantitative Deubiquitinase (DUB) Interactomics to Dissect the Biology of Cancer Associated DUBs
… which plays crucial roles in regulating numerous cellular events. Conversely, deubiquitination is the removal of ubiquitin/polyubiquitin chains from ubiquitinated proteins. Deubiquitination is carried out by the class of enzymes called deubiquitinases (DUBs). These DUBs have vital roles in the …
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The role of VEGF-induced PI3K/Akt signalling pathway in head and neck cancer cell migration
… promoted by Akt phosphorylation is tumour cell motility; however the mechanism of VEGF-induced Akt phosphorylation leading to motility remains poorly understood. Previously, it has been shown that Akt phosphorylation, induced by different factors, causes both stimulation and inhibition of …
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Growth and Characterization of Type-II Submonolayer ZnCdTe/ZnCdSe Quantum Dot Superlattices for Efficient Intermediate Band Solar Cells
… fabricating an efficient intermediate band solar cell.</p> <p>Intermediate band solar cells can potentially have an efficiency of 63.2% under full solar concentration, but the material systems investigated until now are far from optimum and are fraught with growth related issues including low …
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Interactions of shiga-like toxin-2 (Stx-2) from Escherichia coli O157:H7 and the Bcl-2 family of proteins during host cell programmed cell death
… necrosis and apoptosis of a variety of host cells including those of endothelial origin as well as immune cells such as neutrophils (156). However, the role Stx-2 plays in delayed apoptosis of neutrophils is not fully understood given that previous studies have shown conflicting results (118, …
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Combined experimental and modeling studies reveal new mechanisms in T cell antigen recognition
T cells of the immune system recognize small antigen peptide fragments loaded onto Major Histocompatibility Complex (pMHC) molecules through their T Cell Receptor (TCR). The recognition of antigenic pMHC by the TCR is an extremely sensitive and specific process, discriminating as few as a single …
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A Critical Role Of Cxcr2 Pdz Motif-Mediated Interactions In Endothelial Progenitor Cell Homing And Angiogenesis
<p>Bone marrow-derived endothelial progenitor cells (EPCs) participate in postnatal vascularization in response to growth factors, cytokines, and chemokines. Chemokine receptor CXCR2 and its cognate ligands are reported to mediate EPC recruitment and angiogenesis. CXCR2 possesses a consensus …
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The Role of Munc18 Proteins in Physiologic and Pathologic Exocytoses in the Pancreatic Acinar Cell
… fusion events in the polarized pancreatic acinar cell involve highly specific interactions between distinct sets of SNARE proteins forming exocytotic complexes, whose assembly is modulated by distinct Munc18 proteins. The Munc18 isoform responsible for these exocytotic events in the acinar cell is …
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Flap Endonuclease 1 ensures telomere replication and stability
… However, FEN1 depletion did not affect cell cycle progression or in vitro DNA replication through non-telomeric substrates and in the absence of telomere dysfunction, FEN1 depletion did not affect overall genomic stability. Further analysis revealed that FEN1 is important for the …
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Local and Systemic Consequences of Reducing Notch Signaling in Skin Keratinocytes
… short-range signaling between neighboring cells. Notch signaling has been implicated in various cellular and developmental processes essential in the life of metazoans. Specifically, Notch signaling plays a critical role in mammalian skin. Removal of Notch alleles in skin keratinocytes has …
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Identifizierung und Charakterisierung entwicklungsabhängig hochregulierter Gene im Innenohr der Ratte
Durch die außergewöhnlichen Sinnesleistungen benötigt das Säugetiergehör eine Vielzahl spezifischer Proteine. Bislang ist nur ein Teil dieser Proteine bekannt und in ihrer Funktion für das Innenohr beschrieben worden. <br>In dieser Arbeit wurden Gene identifiziert, die während der postnatalen …