Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29680 for “"Cell"”.
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Cellular mechanosensitivity in vitro: cell-ECM, cell-cell, and cell-material interactions
Made available in DSpace on 2015-09-29T21:02:41Z (GMT). No. of bitstreams: 2 ALI-DISSERTATION-2015.pdf: 4946984 bytes, checksum: 649de0269d74763792c883cf2346193d (MD5) LICENSE.txt: 4215 bytes, checksum: b416febe9eaf70ac46d72a4e366da385 (MD5) Previous issue date: 2015-05-13
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Multiplexing cell-cell communication
The engineering of advanced multicellular behaviors, such as the programmed growth of biofilms or tissues, requires cells to communicate multiple aspects of physiological information. Unfortunately, few cell-cell communication systems have been developed for synthetic biology. In this work, I …
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Mechanotransduction at cell-cell contacts
… whether the differences in cadherin- dependent cell-cell adhesion energies could solely predict cell sorting. Although adhesion energies do influence cell sorting in vitro, recent studies suggested that that differences in cell adhesion, determined mainly by cadherin binding affinities and …
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Study of cell-cell communication using 3D living cell microarrays
Cellular behavior is not dictated solely from within; it is also guided by a myriad of external cues. If cells are removed from their natural environment, apart from the microenvironment and social context they are accustomed to, it is difficult to study their behavior in any meaningful way. To …
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Cell culture platforms with cell-cell adhesive ligands for biomedical applications
Cell behavior is regulated by a number of different mechanical and chemical cues within the extracellular microenvironment, including the surrounding matrix and neighboring cells. Although biomaterials have been engineered to present several adhesion molecules that mimic cell-extracellular matrix …
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Chemomechanics at cell-cell and cell-matrix interfaces critical to angiogenesis
The ability to characterize and control cellular responses in vitro has far reaching implications for basic science and applied medical research. For well over 125 years, researchers have studied the behavior of biological cells under in vitro conditions where rigid glass or plastic Petri dishes …
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Mechanical regulation of cell-cell junctions
Cadherins are cell-cell adhesion proteins that mediate cell recognition, segregation, and signaling in many tissues. Recent findings demonstrated that type I classical cadherin complexes are mechanosensitive. Mechanical forces in the tissue environment play a profound role in the growth, …
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E-cadherin mechanotransduction beyond cell-cell junctions
… and integrin receptors form crucial extracellular adhesive connections with, respectively, adjacent cells and the extracellular matrix, and transduce mechanical signals across cell membranes. The role of adhesive complexes in diseases, cardiomyopathies, atherosclerosis, cancer, stem cell …
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Cell-cell communication in three dimensional microenvironments
Cellular behavior is dependent on a variety of extracellular cues required for normal tissue function, wound healing, and activation of the immune system. Removed from their in vivo microenvironment and cultured in vitro, cells lose many environmental cues and that may result in abberant behavior, …
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Vasculogenic Scaffolds: How Cell-Cell and Cell-Matrix Interactions Regulate Vascular Differentiation and Morphogenesis
… is to investigate the vasculogenic potential of cells seeded on two different scaffolds, a commercially available collagen cell carrier (CCC) and the vitelline membrane (VM) from a chick egg. Two cell types with vasculogenic potential were used in this study, human umbilical vein endothelial …
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Homeostatic mechanics for a synthetic cell: predictions on substrate anisotropies and cell-cell interactions
… one or more biological processes, which in cells are known to be highly coupled. This added complexity limits the control over the biocompatibility and biofunctionality of the designed tissues. Amongst the many degrees of freedom in question, substrate topological and mechanical properties, …
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Cell-cell and cell-medium interactions in the growth of mouse embryonic stem cells
Embryonic stem cells serve as powerful models for the study of development and disease and hold enormous potential for future therapeutics. Due to the potential for embryonic stem cells (ESCs) to provide a variety of tissues for use in regenerative medicine, there has been great interest in the …
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Cell cycle perspectives on breast cancer cell behaviour
… important characteristics of aggressive tumour cells. Previous observations in both colorectal cancer and basal cell carcinoma indicated that infiltrative tumour cell behaviour might be counteracted by a high proliferative activity, suggesting a coordination of these two activities at the …
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Mechanisms of Eph/ephrin mediated cell-cell communication
… their membrane associated ephrin ligands mediate cell-cell repulsion to guide migrating cells and axons. A peculiarity of this signaling system is that both receptors and ligands can transduce signals into the cell resulting in a bidirectional signaling mode. An important step of ephrinB ligand …
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Microfluidics for Cell Culture and Single Cell Assays
Elucidating molecular processes that govern cell function is paramount in forming a basis for understanding human health and treating disease. Research is presently limited by investigating in bulk, where information on critical subsets of cells is lost through averaging across an entire …
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Origins of cell-to-cell variability in apoptosis
… even members of a genetically identical group of cells or organisms in identical environments can exhibit variability in state and phenotype. One striking example of such heterogeneity is revealed when a genetically identical population of human cells is exposed to saturating doses of a …
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Sleeper Cell
<p>This thesis contains the manuscript of a genre prose novel, as well as a critical introduction detailing the study of specific elements of craft experimented with in this novel--chiefly, the use of multiple narrators in a novel and the use of traditional stories to inspire and inform new works. …
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Cell Size Control And Asymmetric Cell Fates In Start Of The Saccharomyces cerevisiae Cell Cycle
… mechanisms that couple the process of cell growth to cell division is one of the major challenges of modern cell biology. Saccharomyces cerevisiae (budding yeast) has been an important model organism to study the coupling between cell growth and cell division. The insights obtained from …
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