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Showing 1 to 20 of 33 for “"Celecoxib"”.

  1. Effect of Perioperative Celecoxib on Patient Outcomes After Major Plastic Surgery Procedures

    Sun, Tiffany B.2010

    … to examine the hypothesis that administration of celecoxib preoperatively or postoperatively and for a total of 4 days after major plastic surgery would improve pain control and clinically-important patient outcomes. Another objective of the study was to determine if perioperative administration …

    utswmed Repository record

  2. Einfluss von Celecoxib auf die Entstehung und den Verlauf einer kardialen Hypertrophie

    Grüber, Meike2012

    … dass der selektive Cyclooxygenase (COX)-2 Hemmer Celecoxib den Akt-Signalweg beeinflussen kann. Wir untersuchten den Effekt von Celecoxib auf den Akt-Signalweg in Kardiomyozyten und die hypertrophe Antwort. In isolierten Kardiomyozyten hemmte Celecoxib konzentrationsabhängig (10-100 micromol/L) …

    goettingen Repository record

  3. Effect of Short-Term Postoperative Celecoxib Administration on Patient Outcome After Outpatient Laparoscopic Surgery

    Eng, Matthew R.2011

    … of short-term postoperative administration of celecoxib on pain management and recovery outcomes following laparoscopic surgery. Methods: Eighty consenting ASA I–III outpatients undergoing laparoscopic surgery were randomly assigned to one of two treatment groups: Control (placebo) or Celecoxib …

    utswmed Repository record

  4. Síndrome de la respuesta inflamatoria sistémica experimental inducida por Zymosan A, su regulación con Celecoxib®

    Ortega Casanueva, Luis Antonio2010

    salamanca Repository record

  5. Enhancement of Antitumor Activities of a Selective Cyclooxygenase-2 Inhibitor, Celecoxib on the Lewis Lung Carcinoma that Express Cyclooxygenase-2

    박, 원2011

    … to one of six groups: no treatment(group 1), celecoxib 25mg/kg daily per oral intake alone(group 2), celecoxib 75mg/kg daily per oral intake alone(group 3), 10 Gy irradiation alone in one fraction(group 3), 10 Gy irradiation with celecoxib 25mg/kg daily per oral intake(group 5), 10 Gy …

    ajou Repository record

  6. Pharmacokinetics and pharmacodynamics of some NSAIDs in horses: A pharmacological, biochemical and forensic study

    Subhahar, MichaelUniversity of Central Lancashire2013

    … find a safe NSAID. Two new coxib NSAIDs, namely celecoxib and etoricoxib have been developed and they exert marked beneficial effects in reducing pain in humans and other small animals with little or no side effects. No such study has been done on horses to see if they can tolerate the drug as an …

    cent-lancashire Repository record

  7. The Association of Celecoxib, Rofecoxib, and Non-selective NSAIDs with Indices of Thrombosis and Endothelial Function in the Multi-Ethnic Study of Atherosclerosis

    Allen, StewartWake Forest University2009

    … this discussion to explore mechanisms by which celecoxib, rofecoxib, and nonselective anti-inflammatory medications influence cardiovascular risk. Specifically, I will present data from the Multi-Ethnic Study of Atherosclerosis in order to identify an association of nonsteroidal …

    wfu Repository record

  8. PROSTAGLANDIN E2 PATHWAY AS A TARGET TO PREVENT AND TREAT OVARIAN CANCER IN LAYING HENS

    Eilati, Erfan

    … elongated to form EPA and DHA in the intestine. Celecoxib is a non-steroidal anti-inflammatory (NSAID) drug that selectively inhibits COX-2. There are evidences showing that Celecoxib has some anti-cancer properties. Progress in the treatment and prevention of ovarian cancer has been hampered due …

    siu-theses Repository record

  9. The significance of the EGFR pathway in malignant pleural mesothelioma

    Agarwal, Vijay (Oncologist)Hull York Medical School, the University of Hull and the University of York2012

    … Rapamycin, Ku0063794 (MTOR kinase inhibitor) and Celecoxib as single agents and in combinations and analysed using the MTS assay.ResultsPositive 5-LOX expression was seen in 73% and positive 12-LOX expression was seen in 83% of MPM samples. PTEN protein expression was absent in 27% of the samples. …

    hull Repository record

  10. Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions

    Patel, Sravan Kumar2018

    … platform was developed, incorporating celecoxib for COX-2 inhibition and near-infrared fluorescent dye(s) for fluorescence imaging. We hypothesized that inhibition of COX-2 in macrophages using a theranostic nanoemulsion will reduce the inflammation (and pain), and that this response …

    duquesne Repository record

  11. Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions

    Patel, Sravan Kumar2016

    … platform was developed, incorporating celecoxib for COX-2 inhibition and near-infrared fluorescent dye(s) for fluorescence imaging. We hypothesized that inhibition of COX-2 in macrophages using a theranostic nanoemulsion will reduce the inflammation (and pain), and that this response …

    duquesne Repository record

  12. Metabolomic Insights into the Pharmacological and Genetic Inhibition of Cyclooxygenase-2

    Briggs, William Thomas EdwardUniversity of Cambridge2017

    … to i) profile the metabolic changes induced by celecoxib and rofecoxib, in the mouse; ii) specifically interrogate the effect of celecoxib, rofecoxib and global COX-2 gene deletion on carnitine synthesis, metabolism and shuttling, and iii) explore the advantages and disadvantages of the …

    cambridge Repository record

  13. Immunotherapy for murine glioma

    Tang, BingtaoUniversity of Illinois at Urbana-Champaign2020

    … and the prostaglandin synthesis inhibitor celecoxib (the anti-immunosuppressant) were combined with adoptive transfer of tumor-specific T cells. Two oncolytic poxviruses, vvDD vaccinia virus and myxoma virus, were each engineered to express the fusion protein IL15Ra-IL15 and a fluorescent …

    uiuc Repository record

  14. PGE2 Receptor Subsets Mediate HCG Regulation of the Plasminogen Activator/Plasmin System in Primate Periovulatory Follicles

    Markosyan, Nune2019

    … the prostaglandin (PG) synthesis inhibitor celecoxib. All EP receptor mRNAs were present in granulosa cells. By immunofluorescence, EP1 was detectable only 36 hours after hCG. EP2 and EP3 proteins were present throughout the periovulatory interval. By western blotting, EP2 and EP3 proteins …

    odu Repository record

  15. Pharmacological modulation and manipulation of cancer drug resistance

    Devery, AoifeDublin City University2010

    … and angiogenesis. A COX-2-specific inhibitor, celecoxib, overcame P-gp, MRP1 and BCRP-mediated resistance. At pharmacologically relevant concentrations, celecoxib significantly overcame MRP1 and BCRP-mediated resistance. And to a much lesser extent celecoxib overcame P-gp mediated resistance …

    dcu Repository record

  16. Role of Endogenous Prostaglandins on Kainic Acid Induced Seizure Activity

    김, 희재2011

    … inhibitors such as indomethacin, nimesulide and celecoxib is known to aggravate the kainic acid(KA)-induced seizure activity. However it is not known whether the pro-conversant effect of NSAID was due to the change of endogenous prostaglandins(PGs) and if so, what types are involved. This study …

    ajou Repository record

  17. Repurposing non-antimicrobial drugs to treat multi-drug resistant bacterial and fungal infections

    Thangamani, Shankar

    … drugs (auranofin, ebselen, simvastatin and celecoxib) that exhibited potent antimicrobial activity against multidrug-resistant bacterial and fungal pathogens. Notably, auranofin, an FDA-approved anti-rheumatic drug possessed excellent antibacterial activity against <em>S. aureus</em> and was …

    purdue-thes Repository record

  18. Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow with Exposure to Intermittent Hypoxia in Humans

    Pun, MatiramGraduate Studies2013

    … (50 mg tid/po), selectively COX-2 inhibitor celecoxib (200 mg bid/po) comparing with placebo. Healthy males ingested either of drugs for 4 days and physiological measurements were taken on 5th day with an acute isocapnic-hypoxia challenge pre- and post 6 hrs of IH exposure. Urinary PGs were …

    calgary Repository record

  19. Vascular Kv7 (KCNQ) Potassium Channels As Therapeutic Targets in Cerebral Vasospasm

    Mani, Bharath Kumar2012

    … attenuated in the presence of retigabine. Celecoxib, a clinically used anti-inflammatory drug, not only enhanced Kv7 currents but also inhibited voltage-sensitive Ca2+ currents.</p><p>Functional responses to Kv7 channel modulators were studied in intact basilar artery segments using …

    loyola-thes Repository record

  20. Reactive Oxygen Species (ROS) Triggered Delivery System for the Treatment of Diabetic Retinopathy

    Nayak, RachnaCreighton University2018

    … and proliferation of basal epithelial cells. Celecoxib is reported to be useful in the treatment of DR due to its anti-VEGF activity and anti-proliferative effects on the retinal pigment epithelial (RPE) cells. Another drug memantine is reported to prevent the neurodegeneration in DR by …

    creighton Repository record

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