Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Ceftriaxone"”.
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ΔΙΕΙΣΔΥΣΗ ΤΗΣ ΚΕΦΤΡΙΑΞΟΝΗΣ ΣΤΟΝ ΠΡΟΣΤΑΤΙΚΟ ΙΣΤΟ
CEFTRIAXONE, A NEW SEMISYNTHETIC PARENTERAL CEPHALOSPORIN WITH HIGH ACTIVITY AGAINST BOTH GRAM POSITIVE AND NEGATIVE ORGANISMS WAS FOUND TO HAVE UNIQUE PHARMACOKINETIC PROPERTIES WHICH ALLOWS ONCE A DAY ADMINISTRATION. CLINICAL TRIALSSHOWED ITS EXCELLENT CLINICAL EFFICACY AND SAFETY AND ALSO ITS …
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Immunodulation of inflammation in a murine pnemococcal sepsis model
… of LPS or PBS treated C57bl/6 received 25 mg/kg ceftriaxone at 6 hours post infection. Survival was monitored for 5 days. Blood samples were collected at different time points (6h, 12h and 24h) after bacterial challenge for bacteriological examinations, serum cytokine measurements, and …
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The Role of Trophic Factors and Other Drugs in the Treatment of Huntington's Disease in R6/2 Mouse Model
… a compound that reduces oxidative stress, and Ceftriaxone, a GLT-1 upregulator, would attenuate motor behavioral abnormalities and neurodegeneration in HD R6/2 mouse model.Although we did not observe any behavioral motor improvement with Colivelin and dPEG-Colivelin, we did, in fact, find …
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ΜΕΛΕΤΗ ΠΑΡΑΜΕΤΡΩΝ ΕΓΚΕΦΑΛΟΝΩΤΙΑΙΟΥ ΥΓΡΟΥ ΣΕ ΘΕΡΑΠΕΙΑ ΠΕΙΡΑΜΑΤΙΚΗΣ ΜΗΝΙΓΓΙΤΙΔΑΣ ΑΠΟ HAEMOPHILUS INFLUENZAE TYPE B
… ALONE, DEXAMETHASONE IN COMBINATION WITH CEFTRIAXONE OR CEFTRIAXONE ALONE WAS 404 +-12, 406+-12 AND 411+-14, RESPECTIVELY, VERSUS 419+-10 GM H2O/100 GM DRY WEIGHT IN UNTREATED INFECTED RABBITS (P < 0.05, P < 0.05 AND P < 0.1, RESPECTIVELY, FOR THE THREE TREATMENT MODALITIES, IN COMPARISON …
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Exploring a Novel Anti-Gonococcal Compound for Combating Drug-Resistant <i>Neisseria gonorrhoeae</i>
… CDC-181 (azithromycin-resistant) and WHO-X (ceftriaxone-resistant) were developed to evaluate the activity of potential anti-N. gonorrhoeae compounds. These mutants, CDC-181-rpsLA128G and WHO-X-rpsLA128G, successfully colonized the genital tracts of mice, making them suitable models for …
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The Development of Methods to Account for Physiologic Dynamic Changes and Their Effects on the Pharmacokinetics of Therapeutic Monoclonal Antibodies and other Therapeutics
… ontogeny of MRP2 has on the pharmacokinetics of ceftriaxone to better understand how a transport protein contributes to the disposition of its substrates throughout childhood development. In order to accomplish our aim, a systems pharmacology modeling approach was used to understand MRP2’s …
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A study of clinical strains of Pseudomonas Aeruginosa and the investigation of antibiotic resistance mechanisms in the multidrug resistant strain PA13
… ceftazidime, piperacillin-tazobactam, cefepime, ceftriaxone, meropenem, aztreonam, amikacin, apramycin, butirosin A, lividomycin and colistin sulphate. One of the isolates, PA13, was resistant to a further fourteen antibiotics and was identified as a multidrug resistant strain. A 2.2 kbp PCR …
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Geographical Incidence of Antimicrobial Resistant Gonorrhea
… in the treatment of gonococcal infections: Ceftriaxone injection and oral Azithromycin. These two medications are the last of many that show efficacy in treating gonorrhea, despite increasing resistance. Continued work researching geographic incidence similarities and correlations between …
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Age-Associated Hepatic Drug Transporter Expression and Its Implications for Pediatric Pharmacotherapyflexibility affect DNA topoisomerase I function
… the pharmacokinetics of their drug substrates. Ceftriaxone, a third generation cephalosporin antibiotic frequently used in pediatric pharmacotherapy, was selected as our model compound. The pharmacokinetics of a single intravenous dose of ceftriaxone was compared between wild-type (WT) Wistar …
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Optimization of Enantiopure tetrahydro-β-carbolines as Potent Antimalarials and Exploration of salicylic acid analogs for combating multidrug-resistant Neisseria gonorrhoeae
… health. Dual therapy of azithromycin (AZM) and ceftriaxone has been the standard-of-care for treatment of gonococcal infections. However, due to increasing resistance to azithromycin (>33% in some regions) the CDC removed AZM from the treatment regimen for gonorrhea in 2020. Therefore, …
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In vitro activity of cephalosporins against selected gram negative bacilli : [a thesis]
… Ceftizoxime, Cefotaxime, Cefoperazone, Ceftriaxone, Moxalactam) were studied against 146 strains of Gram negative bacilli belonging to the following families: Enterobacteriaceae Proteus vulgarius (2), P. mirabilis (5), Providencia stuartti (6), P. alkalifaciens (5), Morganella morganii …
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Investigating FDA-Approved Drugs for Treatment of Multidrug-Resistant Neisseria gonorrhoeae
… N. gonorrhoeae completely, which is superior to ceftriaxone. In conclusion, itraconazole, isavuconazole, and ravuconazole merit future investigation for the development of anti-gonorrheal therapeutics. This study provided unexplored avenues and promising opportunities that can be further …
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The Invisible Force: Optimizing Novel Approaches in Anesthesiology and Infectious Diseases
… bacterial load. Combined treatment with AMF and ceftriaxone (or linezolid) showed a 5-log decrease in bacterial load after 24 hours, whereas singular treatment with AMF or abx alone showed total regrowth or moderate decrease in bacterial load respectively. Chapter 2 describes a meta-analysis …
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Characterization of β-lactamases and Porins in Uropathogenic E. coli
… with non-susceptibility to cephalosporins ceftriaxone, cefoxitin, ceftazidime and cefepime but not the carbapenems. Except for the KPC producers, the isolates were largely susceptible to the carbapenems meropenem, ertapenem and imipenem. (3) KPC protein levels could not explain variability …
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The effects of some antibiotics and lipopolysaccharide on oxidative burst and phagocytosis of neutrophils
… The antibiotics used were the following: Ceftriaxone, ciprofloxacin, clindamycin, doxycycline, enoxacin, imipenem, norfloxacin, pefloxacin, teicoplanin, tetracycline and vancomycin. Blood from healthy subjects was exposed to concentrations of the above antibiotics ranging from 0.1 to 200 …
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Syphilis in Pregnancy: Exploring the prevalence and vertical transmission prevention cascade of syphilis using routinely collected electronic health data, Cape Town Metropolitan District, 2017–2022
… amoxicillin with enzyme inhibitor; <1% received ceftriaxone. Only 23% of syphilis-positive women had a follow-up RPR titre. The risk of adverse pregnancy outcomes was higher among syphilis seropositive compared to seronegative women; neonatal deaths RR 1.91 (95% CI 1.53-2.38) and RR of …
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Urinary tract infection in children at Victoria Hospital, a district hospital in Cape Town, South Africa
… empiric treatment for children with UTI, with ceftriaxone included as an alternative for neonates or acutely ill infants. Methods: A retrospective review of medical records and laboratory results of children <10 years of age who had a urine specimen submitted for culture and AST to the National …
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Understanding Bacterial Resistance and Dissemination: The Impact of Biocide Priming
… increases in MIC to cephalothin and four-fold to ceftriaxone and ampicillin were observed in hydrogen peroxide primed E. coli and thioridazine increased the susceptibility of E. coli to cephalothin and cefoxitin. The ompF porin gene was downregulated by 30.5-fold after exposure to hydrogen …
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Glutamate and MDMA Neurobehavioral Toxicity
… of the GLT-1 glutamate transporter with ceftriaxone, mGluR2/3 stimulation via LY379268, and inhibition of the cystine-glutamate antiporter (Xc-) with 4-S-carboxyphenylglycine (CPG) each attenuated the observed glutamate efflux. The results strongly suggest the likely source of glutamate …
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Characterization of probiotic Lactobacillus spp. isolates from commercial fermented milks
… (MIC). The acquired resistance to cefoxitin, ceftriaxone, chloramphenicol, erythromycin, gentamycin, kanamycin, lincomycin, streptomycin, tylosin tartarate, tetracycline and vancomycin was observed in all tested isolates. Also their genetic background of antibiotic resistance genes was studied …
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