Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Cdx2"”.
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Gata4 et Cdx2 sont des régulateurs transcriptionnels intestinaux du gène encodant la protéine sécrétoire de type lectine Pap1
… de Gata4 pour l'ADN dans les cellules IEC-6/Cdx2. Les essais luciférase ont démontré que Gata4, en combinaison avec Cdx2, amène un effet synergique important sur l'activité du promoteur de Pap1 de l'ordre d'environ 8 fois. Différents mutants de la protéine Gata4 ont montré une abolition du …
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The Role of Cdx in Intestinal Development
The products of the Cdx genes, Cdx1, Cdx2 and Cdx4, are known to play essential roles in many developmental processes including neural tube closure, axial elongation and patterning the anterior-posterior axis of the developing embryo. Cdx1 and Cdx2 are both expressed in the endoderm of the embryo …
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Modeling colorectal cancer initiation using human iPSC-derived intestinal organoids
… literature in the field of CRC. METHODS: A CDX2-GFP reporter hiPSC line was transfected independently with three constructs each containing a doxycycline (Dox) -inducible promoter driving expression of a mutant EGFR, KRAS, or CTNNB1 followed by the BFP reporter knocked-in into the AAVS1 safe …
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Transcriptional regulation of metastatic progression in lung adenocarcinoma
… three transcription factors - Nkx2-1, Foxa2, and Cdx2. These three factors were highly expressed in non-metastatic cells, and downregulated in metastatic cells. Altered expression of these factors led to commensurate changes in Tks5long levels. Finally, we demonstrated that Nkx2-1, Foxa2, and Cdx2 …
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Genome-wide CRISPR Screens to Uncover Novel Therapeutic Targets in Wnt-β-catenin Driven Gastrointestinal Cancers
… identified the homeobox transcription factor CDX2 as a context-dependent fitness gene and Wnt-β-catenin transcriptional target in RNF43 mutant pancreatic cancer cells. CDX2 is uniquely overexpressed in Wnt-FZD5 dependent PDAC cells and transcriptome analysis revealed it may drive an intestinal …
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Conversion of equine umbilical cord matrix mesenchymal stem cells to the trophectoderm lineage using the Yamanaka reprogramming factors
… NANOG, but did express the trophectoderm markers CDX2 and TFAP2A. Both OCT4 and CDX2 were colocalized to the nucleus. The transduced equine cells were termed equine induced trophoblast (iTr) cells. Culture of the iTr cell in suspension resulted in formation of blastocyst-like spheres rather than …
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An ancestral regulatory mechanism underlies Hoxd gene expression in both developing genitals and digits
… one of these two structures. We identified Cdx2 transcription factor as a putative interactor of the genitalspecific enhancers. These results suggest a common ancestral regulatory strategy for digits and genitals, yet with specific adaptations in each developmental context. This work should …
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Interleukin-6 and its Contribution to Embryogenesis in Cattle
… that were negative for its traditional marker, CDX2. This suggests IL6ST is likely involved in a pathway responsible for determining cell fate identity at the blastocyst stage. Collectively, IL6 in cooperation with IL6ST, is a key controller of embryogenesis in cattle.
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Genetic and Molecular Characterization of Programmed Cell Death in the C.elegans Tail-Spike Cell
… homolog of the mammalian tumor suppressor gene Cdx2. PAL-1 can bind to ced-3 promoter sites critical for tail-spike cell death, suggesting that it promotes cell death by directly activating ced-3 transcription. Our results highlight a previously undescribed role for transcriptional regulation of …
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Epigenetic Regulation Controls Intrinsic and Extrinsic Drivers of Gastrointestinal Development
… and hindgut lineage-specific TFs, Sox2 and Cdx2, leads to fate shifts in chromatin accessibility patterns, linking TFs, accessibility, and lineage fate decisions in gut development. Finally, I demonstrated that Sox2 overexpression in early development induces pancreatic transformation into …
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A multi-lineage in vitro mouse embryo model derived exclusively from mouse embryonic stem cells
… shown that ESCs that transiently overexpressed Cdx2 upon doxycycline induction could effectively replace TSCs to form embryo-like structures. The resulting ‘EiTiX-embryoids’ underwent development from pre-gastrulation stages to neurulation stages, developing headfolds, a beating heart structure, …
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Modelling human liver bud development in vitro
… hepato- pancreato-biliary progenitors (KRT19+CDX2+PDX1+HNF1B+) and extra-hepatic cholangiocytes (ACE2+MUC13+). By performing extensive snRNAseq analyses across HepBud formation, I was able to validate that hepatic specification in HepBuds follows a natural developmental path forming …
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IMPACT OF NUTRIENT IMBALANCE ON THE EPIGENETIC SIGNATURE AND GENE EXPRESSION OF BOVINE EARLY EMBRYOS
… and the expression of lineage markers (SOX2, CDX2, and NANOG) remained largely consistent across treatments, suggesting that early embryonic development is resilient to mild nutritional fluctuations. Additionally, differential transcript usage (DTU) - which has been implicated in disease onset …
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The Role of Amino Acids and the Threonine-SAM Pathway in the Development of Bovine Inner Cell Mass and Pluripotency
… epiblast (NANOG, FGF4, and SOX2) and TE (CDX2) markers were not altered in the Qc1 group compared to DMSO controls. Qc1 also severely compromised mouse embryos cultured from day 1-4. In bovine cells, Qc1 compromised fresh ICM, D6 ICM outgrowths and fresh TE cells but failed to impair D6 TE …
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Coordination and lonic compounds of benzamide and related molecules and metal halides
… as inorganic components, including CuX2, CdX2, CoX2, MnX2, HgX2 and ZnX2, where X = Cl or Br. Both ionic and neutral coordination type materials can be formed through the combination of the organic components and inorganic components described above, and the outcome of the reaction is …
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Thiosemicarbazone, xanthate and dithiocarbamate single source precursors for cadmium, lead and indium sulfide nanoparticles
… outlined briefly. In the second chapter, eight CdX2 (X = Clˉ, Iˉ) thiosemicarbazone complexes were prepared and subsequently evaluated as single source molecular precursors towards the fabrication of oleylamine-capped CdS nanoparticles through a solvent thermolysis route. Various reaction …