Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Cdx"”.
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The Role of Cdx in Intestinal Development
The products of the Cdx genes, Cdx1, Cdx2 and Cdx4, are known to play essential roles in many developmental processes including neural tube closure, axial elongation and patterning the anterior-posterior axis of the developing embryo. Cdx1 and Cdx2 are both expressed in the endoderm of the embryo …
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Fulfilling the promise of targeted therapeutics in oncology via companion diagnostics : a perspective on pipeline trends and co-development strategies
… developed companion diagnostics (CDx) could lead to more efficacious use of a cancer therapeutic in a selected population. Despite a gap of 12 years, the recent approvals of Zelboraf and Xalkori in quick succession by the FDA are a testament to the fact that the age of cancer …
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Gut Patterning In Development And Evolution: A Comparative Differential Transcriptomics Approach
… star embryo, focusing on the role that Xlox and Cdx transcription factors have in this process in both echinoderm species. Taking advantage of genome-wide approaches and modern high-throughput technologies, a partial reconstruction of the sea urchin GRN around Xlox and Cdx transcription factors, …
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Structural studies on some bivalent metal complexes.
… of the donor ligands. The related (R[3]P)CdX[2] complexes have been crystallographically and spectroscopically investigated. The following crystal structures have been determined: (3) (Et[3]P)CdI[2] - discrete dimer (4) alpha-(Cy[3]P)CdCl[2] - discrete tetramer (5-7) (Me[2]PhP)CdX[2] [X = …
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Heat transfer analysis of thermoelectric driven swirling flow
… as the divertor material. An experiment on CDX-U found that a shallow pool of liquid lithium could bear 60MW/m2 heat flux without significant evaporation. A swirling flow pattern was observed during the experiment which was firstly believed to be Marangoni effect. To reveal the truth of this …
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Essays in credit derivatives
… The event is when a CDS is included into the CDX index. This event changes the liquidity of CDS because they will be traded in the more liquid CDX market. If the CDS market is already liquid, we should observe no change in the level or correlation of CDS spreads. However, the spread levels do …
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Essays in MacroFinance
… theory correctly predicts that inclusion in the CDX index increases the underlying CDS basis. In Chapter 2, I study the use of secured and unsecured debt by nonfinancial firms for financing. I find that firms with a higher fraction of their assets pledged respond more strongly to contractionary …
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Quantitative Modeling of Credit Derivatives
… of CDS spreads, using time series of the CDX Investment Grade index constituents from 2005 to 2009. We then propose a heavy-tailed multivariate time series model for CDS spreads that captures these properties. Our model can be used as a framework for measuring and managing the risk of CDS …
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MementoMap: A Web Archive Profiling Framework for Efficient Memento Routing
… Identifier (URI). Using the Crawler Index (CDX), we generate profiles of the archives that summarize their holdings and use them to inform routing of the Memento aggregator’s URI requests. Additionally, we use full text search (when available) or sample URI lookups to build an understanding …
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A Microfluidic Tissue Array (µFTA) For Personalized Medicine using Tumor Biopsies
… tumor biopsies from cell-derived xenografts (CDX, e.g. MB-MDA-231 and BT 474) and patient-derived xenografts (PDX, e.g. M37 and M156) breast cancer models. As this work was in progress, other labs have also worked on creating a whole tissue culture system, but employ very low-throughput …
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Three Essays in Empirical Asset Pricing
The financial crisis of 2007-2008 led to extraordinary government intervention in firms and markets. The scope and depth of government action rivaled that of the Great Depression. Many traded markets experienced dramatic declines in liquidity leading to the existence of conditions normally assumed …